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  • T62155JAK1-IN-9；化合物 JAK1-IN-9JAK1-IN-9

    JAK1-IN-9 (compound 23a) is a potent, selective inhibitor of JAK1, demonstrating an IC50 of 72 nM. It exhibits over 12-fold selectivity against other JAK family members [1].

    价 格：￥电议型 号：T62155产 地：中国大陆

  • T62096Dyrk1A/α-synuclein-IN-1；化合物 Dyrk1A/α-synuclein-IN-1Dyrk1A/α-synuclein-IN-1

    Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM). CNS permeability and neuroprotective activity.

    价 格：￥电议型 号：T62096产 地：中国大陆

  • T62043Dyrk1A/B-IN-1；化合物 Dyrk1A/B-IN-1Dyrk1A/B-IN-1

    Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable inhibitor of DYRK1A and DYRK1B. Dyrk1A/B-IN-1 inhibits DYRK1A and DYRK1B with Kis of 67.8 nM and 237.9 nM, and IC 50 s of 1.1 μM and 0.8 μM, respectively.

    价 格：￥电议型 号：T62043产 地：中国大陆

  • T61992SIK1 activator 1；化合物 SIK1 activator 1SIK1 activator 1

    SIK1 activator 1 can enhances the SIK1 phosphorylation and ameliorated the hyperglyceamia of type 2 diabetic mice. SIK1 activator 1 exhibited remarkable inhibitory activity on hepatic gluconeogenesis.

    价 格：￥电议型 号：T61992产 地：中国大陆

  • T6198Dolutegravir；度鲁特韦S/GSK1349572|||GSK1349572；S/GSK1349572|||GSK1349572|||度鲁特韦|||多替拉韦

    Dolutegravir (GSK1349572) (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.

    价 格：￥电议型 号：T6198产 地：中国大陆

  • T61965SphK1-IN-1；化合物 SphK1-IN-1SphK1-IN-1

    SphK1-IN-1 is an inhibitor of SphK1 with anti-tumor activity. SphK1-IN-1 inhibits the ATPase of SphK1, IC50=2.48 μM. SphK1-IN-1 has the value of cancer research.

    价 格：￥电议型 号：T61965产 地：中国大陆

  • T61887RIPK1-IN-13；化合物 RIPK1-IN-13RIPK1-IN-13

    RIPK1-IN-13 (Compound 8) is an effective RIPK1 inhibitor (IC50=1139 nM). By inhibiting RIPK1, RIPK1-IN-13 can block the activation of necrotic apoptosis pathway. RIPK1-IN-13 has research potential in inflammatory diseases.

    价 格：￥电议型 号：T61887产 地：中国大陆

  • T61843CK156；化合物 CK156CK156

    CK156 is a potent inhibitor of death-associated protein kinase (DAPK), demonstrating high selectivity. In the DRAK1 NanoBRET assay, CK156 exhibits IC50 values of 182 nM, 34 μM, and 39 μM for DRAK1, CK2a1, and CK2a2, respectively. This compound is valuable for studying autoimmune and inflammatory diseases [1].

    价 格：￥电议型 号：T61843产 地：中国大陆

  • T6176IKK 16；化合物IKK16IKK Inhibitor VII|||IKK-16|||IKK16；IKK Inhibitor VII|||IKK-16|||IKK16

    IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

    价 格：￥电议型 号：T6176产 地：中国大陆

  • T61739Dyrk1A-IN-5；化合物 Dyrk1A-IN-5Dyrk1A-IN-5

    Dyrk1A-IN-5 (compound 5j) is a highly potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 6 nM. It dose-dependently diminishes the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Moreover, Dyrk1A-IN-5 effectively inhibits the phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Given these properties, Dyrk1A-IN-5 is a valuable tool for Down syndrome research [1].

    价 格：￥电议型 号：T61739产 地：中国大陆

  • T61733HPK1-IN-25；化合物 HPK1-IN-25HPK1-IN-25

    HPK1-IN-25 (example 94), an inhibitor of hematopoietic progenitor kinase 1 (HPK1), demonstrates enzymatic activity with an IC50 value of 129 nM, indicating its potential utility in cancer research [1].

    价 格：￥电议型 号：T61733产 地：中国大陆

  • T61693AAK1-IN-5；化合物 AAK1-IN-5AAK1-IN-5

    AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivity, with an AAK1 inhibitory potency (IC 50) of 1.2 nM, a binding affinity (K i) of 0.05 nM, and an inhibitory potency against cellular AAK1 activity (cell IC 50) of 0.5 nM. AAK1-IN-5 holds promise for investigating neuropathic pain in scientific research [1].

    价 格：￥电议型 号：T61693产 地：中国大陆

  • T61584ASK1-IN-3；化合物 ASK1-IN-3ASK1-IN-3

    ASK1-IN-3 is a highly potent and selective inhibitor of ASK1 kinase, demonstrating an IC 50 of 33.8 nM. This compound also exhibits inhibitory effects on various cell cycle regulating kinases. ASK1-IN-3 showcases remarkable induction of apoptosis in HepG2 cancer cells and displays potent activity in arresting the cell cycle [1].

    价 格：￥电议型 号：T61584产 地：中国大陆

  • T61543CLK1/4-IN-1；化合物 CLK1/4-IN-1CLK1/4-IN-1

    CLK1/4-IN-1 (compound 31) is a highly potent and selective inhibitor of Clk1 and Clk4, with IC50 values of 9.7 nM and 6.6 nM, respectively. It effectively inhibits the growth of T24 cancer cells, with a GI50 value of 1.1 μM. CLK1/4-IN-1 has shown promising potential as an anticancer research tool [1].

    价 格：￥电议型 号：T61543产 地：中国大陆

  • T61499AAK1-IN-4；化合物 AAK1-IN-4AAK1-IN-4

    AAK1-IN-4 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), capable of efficiently penetrating the central nervous system and exhibiting oral bioactivity. It has demonstrated a high degree of selectivity with an AAK1 inhibitory concentration (IC50) of 4.6 nM, a Filt dissociation constant (Ki) of 0.9 nM, and a cellular IC50 of 8.6 nM. AAK1-IN-4 holds promise as a valuable tool in the investigation of neuropathic pain [1].

    价 格：￥电议型 号：T61499产 地：中国大陆

  • T61449HPK1-IN-18；化合物 HPK1-IN-18HPK1-IN-18

    HPK1-IN-18 is a highly effective and specific HPK1 inhibitor. HPK1, a MAP kinase kinase kinase kinases (MAP4K) member, was initially isolated from hematopoietic progenitor cells. This compound, known as HPK1-IN-18, is valuable for investigating, preventing, or managing diseases or conditions linked to HPK1 activity, such as cancer[1].

    价 格：￥电议型 号：T61449产 地：中国大陆

  • T61437HPK1-IN-26；化合物 HPK1-IN-26HPK1-IN-26

    HPK1-IN-26, a novel compound, is a potent inhibitor of both HPK1 and GLK. This small molecule exhibits promise in aiding the study of animal pathogen infection [1].

    价 格：￥电议型 号：T61437产 地：中国大陆

  • T6129GSK-1070916；化合物GSK1070916GSK-1070916A|||GSK1070916；GSK-1070916A|||GSK1070916

    GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.

    价 格：￥电议型 号：T6129产 地：中国大陆

  • T61254CDK1/Cyc B-IN-1；化合物 CDK1/Cyc B-IN-1CDK1/Cyc B-IN-1

    CDK1/Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1/Cyc B complex, demonstrating selectivity with an IC50 value of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest, effectively halting cancer cell proliferation. Additionally, CDK1/Cyc B-IN-1 exhibits a wide-ranging cytotoxic effect on various cancer cell lines [1].

    价 格：￥电议型 号：T61254产 地：中国大陆

  • T6098Cabotegravir；卡博特韦GSK744|||GSK-1265744|||S/GSK1265744；GSK744|||GSK-1265744|||卡博特韦|||S/GSK1265744

    Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).

    价 格：￥电议型 号：T6098产 地：中国大陆

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