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T80062Mitogen-activated protein kinase 1;化合物 Mitogen-activated protein kinase 1MAPK1;MAPK1
Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases. Its catalytic action phosphorylates substrate proteins, serving as a regulatory switch for their activity [1].
价 格:¥电议型 号:T80062产 地:中国大陆
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T79860TIE-2/VEGFR-2 kinase-IN-5;TIE-2/VEGFR-2 kinase 抑制剂5TIE-2/VEGFR-2 kinase-IN-5
TIE-2/VEGFR-2 kinase-IN-5 is a potent TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor with anti-angiogenic activity and is commonly used in biomedical research related to angiogenesis.
价 格:¥电议型 号:T79860产 地:中国大陆
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T79859TIE-2/VEGFR-2 kinase-IN-4;化合物 TIE-2/VEGFR-2 kinase-IN-4TIE-2/VEGFR-2 kinase-IN-4
TIE-2/VEGFR-2 kinase-IN-4, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting inhibitory concentration (IC50) values of 5.2 nM and 5.1 nM, respectively. This compound is utilized in angiogenesis research [1].
价 格:¥电议型 号:T79859产 地:中国大陆
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T79858TIE-2/VEGFR-2 kinase-IN-3;化合物 TIE-2/VEGFR-2 kinase-IN-3TIE-2/VEGFR-2 kinase-IN-3
TIE-2/VEGFR-2 kinase-IN-3, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting IC50 values of 6.9 nM and 3.5 nM, respectively. This compound is useful for angiogenesis research [1].
价 格:¥电议型 号:T79858产 地:中国大陆
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T79807JAK kinase-IN-1;化合物 JAK kinase-IN-1JAK kinase-IN-1
JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32 nM, 27 nM, and 3473 nM, respectively [1].
价 格:¥电议型 号:T79807产 地:中国大陆
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T79697Casein kinase 1δ-IN-10;化合物 Casein kinase 1δ-IN-10Casein kinase 1δ-IN-10
Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).
价 格:¥电议型 号:T79697产 地:中国大陆
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T79612Tyrosine kinase-IN-6;化合物 Tyrosine kinase-IN-6Tyrosine kinase-IN-6
Tyrosine kinase-IN-6 is a potent inhibitor of RON splice variants, demonstrating significant anticancer and antineoplastic effects [1].
价 格:¥电议型 号:T79612产 地:中国大陆
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T79605RIP1 kinase inhibitor 8;化合物 RIP1 kinase inhibitor 8RIP1 kinase inhibitor 8
RIP1 Kinase Inhibitor 8 (Compound 77), a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor, exhibits an IC50 of 20 nM and effectively prevents necrotic cell death. It also demonstrates a favorable pharmacokinetic profile across multiple species [1].
价 格:¥电议型 号:T79605产 地:中国大陆
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T79154Casein kinase 1δ-IN-5;化合物 Casein kinase 1δ-IN-5Casein kinase 1δ-IN-5
Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in vitro, with potential applications in neurodegenerative disease research.
价 格:¥电议型 号:T79154产 地:中国大陆
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T79127Casein kinase 1δ-IN-4;化合物 Casein kinase 1δ-IN-4Casein kinase 1δ-IN-4
"Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer´s disease research [1]."
价 格:¥电议型 号:T79127产 地:中国大陆
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T79126Protein kinase inhibitor 5 sulfate hydrate;化合物 Protein kinase inhibitor 5 sulfate hydrateProtein kin
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].
价 格:¥电议型 号:T79126产 地:中国大陆
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T79125Protein kinase inhibitor 5;化合物 Protein kinase inhibitor 5Protein kinase inhibitor 5
Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].
价 格:¥电议型 号:T79125产 地:中国大陆
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T79063IRE1α kinase-IN-9;化合物 IRE1α kinase-IN-9IRE1α kinase-IN-9
IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM. It is suitable for research into diseases linked to the unfolded protein response or regulated IRE1-dependent decay (RIDD) [1].
价 格:¥电议型 号:T79063产 地:中国大陆
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T79062IRE1α kinase-IN-8;化合物 IRE1α kinase-IN-8IRE1α kinase-IN-8
IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α. This compound is utilized in research pertaining to diseases linked to the unfolded protein response and regulated IRE1-dependent decay (RIDD) [1].
价 格:¥电议型 号:T79062产 地:中国大陆
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T79044RIP1 kinase inhibitor 7;化合物 RIP1 kinase inhibitor 7RIP1 kinase inhibitor 7
RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM. Additionally, it demonstrates an EC50 ranging from 1 to 100 nM in cell necrosis assays [1].
价 格:¥电议型 号:T79044产 地:中国大陆
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T79043RIP1 kinase inhibitor 6;化合物 RIP1 kinase inhibitor 6RIP1 kinase inhibitor 6
RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1 kinase assay[1].
价 格:¥电议型 号:T79043产 地:中国大陆
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T79042RIP1 kinase inhibitor 5;化合物 RIP1 kinase inhibitor 5RIP1 kinase inhibitor 5
RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) in suppressing necrosis and ferroptosis [2].
价 格:¥电议型 号:T79042产 地:中国大陆
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T79041RIP1 kinase inhibitor 4;化合物 RIP1 kinase inhibitor 4RIP1 kinase inhibitor 4
RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].
价 格:¥电议型 号:T79041产 地:中国大陆
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T79028p38 Kinase inhibitor 4;化合物 p38 Kinase inhibitor 4p38 Kinase inhibitor 4
Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].
价 格:¥电议型 号:T79028产 地:中国大陆
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T78980Pim-1 kinase inhibitor 5;化合物 Pim-1 kinase inhibitor 5Pim-1 kinase inhibitor 5
Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-116, with IC50 values ranging from 6.95 to 20.19 μM [1].
价 格:¥电议型 号:T78980产 地:中国大陆