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T8006Oncrasin-11-(4-氯苄基)-1H-吲哚-3-甲醛1-(4-氯苄基)-1H-吲哚-3-甲醛
Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
价 格:¥电议型 号:T8006产 地:中国大陆
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T79928Phosphomannose isomerase;化合物 Phosphomannose isomerasePhosphomannose isomerase
Phosphomannose isomerase, the initial enzyme in GDP-Man biosynthesis, catalytically facilitates the interconversion of fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P), playing a crucial role in cell wall synthesis and protein glycosylation. It is also recognized as a significant antifungal target against threats from A. flavus [1].
价 格:¥电议型 号:T79928产 地:中国大陆
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T79926Poly(A) polymerase;化合物 Poly(A) polymerasePoly(A) polymerase
Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3´ end of RNA, a process that involves integrating ATP as AMP. This modification enhances RNA stability and augments mRNA translation efficiency in eukaryotic cells, evidencing the enzyme´s high tailing efficiency [1] [2].
价 格:¥电议型 号:T79926产 地:中国大陆
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T79923T7 RNA polymerase;T7 RNA聚合酶T7 RNA polymerase
T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcription (IVT) of mRNA. This polymerase requires Mg 2+ and selects only DNA templates that contain the T7 promoter sequence, whether single-stranded or double-stranded. It employs NTPs to synthesize RNA that is complementary to the single-stranded DNA following the promoter [1] [2].
价 格:¥电议型 号:T79923产 地:中国大陆
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T79922Taq DNA polymerase;化合物 Taq DNA polymeraseTaq DNA polymerase
Taq DNA polymerase is a thermostable enzyme utilized in polymerase chain reactions (PCR) to amplify DNA sequences [1].
价 格:¥电议型 号:T79922产 地:中国大陆
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T79814pan-KRAS-IN-3;化合物 pan-KRAS-IN-3pan-KRAS-IN-3
Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].
价 格:¥电议型 号:T79814产 地:中国大陆
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T79808KRAS G12C inhibitor 61;化合物 KRAS G12C inhibitor 61KRAS G12C inhibitor 61
KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM. This inhibitor is applicable in the research of pancreatic, colorectal, and lung cancers [1].
价 格:¥电议型 号:T79808产 地:中国大陆
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T79800pan-KRAS-IN-2;化合物 pan-KRAS-IN-2pan-KRAS-IN-2
Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 >10 μM, for the KRAS G13D mutant [1].
价 格:¥电议型 号:T79800产 地:中国大陆
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T79799pan-KRAS-IN-4;化合物 pan-KRAS-IN-4pan-KRAS-IN-4
Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].
价 格:¥电议型 号:T79799产 地:中国大陆
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T79539Topoisomerase II inhibitor 16;化合物 Topoisomerase II inhibitor 16Topoisomerase II inhibitor 16
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded DNA-enzyme cleavage complexes. It shows promise for research into Chagas disease [1].
价 格:¥电议型 号:T79539产 地:中国大陆
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T79506Topoisomerase II inhibitor 15;化合物 Topoisomerase II inhibitor 15Topoisomerase II inhibitor 15
Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1].
价 格:¥电议型 号:T79506产 地:中国大陆
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T79415Antiparasitic agent-18;化合物 Antiparasitic agent-18Antiparasitic agent-18
Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T. brucei (EC 50 =0.4 ?M), T. cruzi (EC 50 =0.21 ?M), and L. donovani (EC 50 =0.26 ?M) [1].
价 格:¥电议型 号:T79415产 地:中国大陆
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T79308DNA polymerase-IN-3;化合物 DNA polymerase-IN-3DNA polymerase-IN-3
DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in proliferative disease research [1].
价 格:¥电议型 号:T79308产 地:中国大陆
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T79307DNA polymerase-IN-2;化合物 DNA polymerase-IN-2DNA polymerase-IN-2
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, demonstrates inhibitory activity towards Taq DNA polymerase, with an IC50 value of 48.25 μM, and holds potential for application in value-added disease research [1].
价 格:¥电议型 号:T79307产 地:中国大陆
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T79240DNA gyrase B-IN-2;化合物 DNA gyrase B-IN-2DNA gyrase B-IN-2
DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE pathogens. The compound exhibits potent nanomolar-range inhibition (IC 50 < 10 nM) and a broad-spectrum antibacterial effect, with minimum inhibitory concentrations below 0.03 μg/mL for most Gram-positive species and between 4–16 μg/mL for Gram-negative species including E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pn
价 格:¥电议型 号:T79240产 地:中国大陆
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T791974-Thiouridine 5′-triphosphate tetrasodium;化合物 4-Thiouridine 5′-triphosphate tetrasodium4-Thio-UTP te
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium functions as a potent agonist at P2Y 2 and P2Y 4 receptors, with half-maximal effective concentrations (EC 50 s) of 35 nM for hP2Y 2 and 350 nM for hP2Y 4 . This compound is applicable in studies involving crosslinking experiments and labeling of the transcriptional complex [1] [2].
价 格:¥电议型 号:T79197产 地:中国大陆
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T79166KRAS G12C inhibitor 60;化合物 KRAS G12C inhibitor 60KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and pancreatic cancers [1].
价 格:¥电议型 号:T79166产 地:中国大陆
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T79162SOS1/KRAS-IN-1;化合物 SOS1/KRAS-IN-1SOS1/KRAS-IN-1
SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].
价 格:¥电议型 号:T79162产 地:中国大陆
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T79150KRAS G12C inhibitor 59;化合物 KRAS G12C inhibitor 59KRAS G12C inhibitor 59
KRAS G12C Inhibitor 59 is a compound with anticancer properties.
价 格:¥电议型 号:T79150产 地:中国大陆
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T79148PROTAC KRAS G12C degrader-3;化合物 PROTAC KRAS G12C degrader-3PROTAC KRAS G12C degrader-3
PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].
价 格:¥电议型 号:T79148产 地:中国大陆