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T14161Ald-PEG1-C2-Boc；化合物 T14161Ald-PEG1-C2-Boc
Ald-PEG1-C2-Boc is an alkyl-ether-based linker utilized for the synthesis of PROTACs, a class of small molecules that induce targeted protein degradation[1].
价 格：￥电议型 号：T14161产 地：中国大陆
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T14160Ald-CH2-PEG5-Boc；化合物 T14160Ald-CH2-PEG5-Boc
Ald-CH2-PEG5-Boc is a PEG- and Alkyl/ether-based PROTAC linker suitable for synthesizing PROTACs[1].
价 格：￥电议型 号：T14160产 地：中国大陆
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T1416Zidovudine；叠氮胸苷Azidothymidine|||NSC 602670|||ZDV|||AZT；Azidothymidine|||NSC 602670|||ZDV|||齐多夫定|||AZ
Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines.
价 格：￥电议型 号：T1416产 地：中国大陆
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T14159Ald-CH2-PEG5-azide；化合物 T14159Ald-CH2-PEG5-azide
Ald-CH2-PEG5-azide is a non-cleavable linker consisting of a five unit PEG chain, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格：￥电议型 号：T14159产 地：中国大陆
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T14158Ald-CH2-PEG3-CH2-Boc；化合物 T14158Ald-CH2-PEG3-CH2-Boc
Ald-CH2-PEG3-CH2-Boc, a PEG- and Alkyl/ether-based PROTAC linker, is utilized for the synthesis of SGK3 kinase PROTAC degrader[1].
价 格：￥电议型 号：T14158产 地：中国大陆
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T14157Ald-CH2-PEG4-Boc；化合物 T14157Ald-CH2-PEG4-Boc
Ald-CH2-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T14157产 地：中国大陆
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T14156Ald-CH2-PEG3-azide；化合物 T14156Ald-CH2-PEG3-azide
Ald-CH2-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格：￥电议型 号：T14156产 地：中国大陆
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T14155Ald-C2-PEG4-azide；化合物 T14155N3-PEG4-CH2CH2CHO；N3-PEG4-CH2CH2CHO
Ald-C2-PEG4-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T14155产 地：中国大陆
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T14154Alclometasone；化合物 T141547a-?Chloro-?16a-?methyl prednisolone；7a-?Chloro-?16a-?methyl prednisolone
Alclometasone (7a-Chloro-16a-methyl prednisolone), a glucocorticoid, inhibits leukocytes from releasing pro-inflammatory mediators. It is effective in treating corticosteroid-responsive dermatoses such as atopic dermatitis, psoriasis, allergic dermatitis, and eczema [1].
价 格：￥电议型 号：T14154产 地：中国大陆
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T14153Aladorian；化合物 T14153ARM036；ARM036
Aladorian (ARM036) is a benzothiazepine derivative and it has anti-arrhythmia effect. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia[1][2].
价 格：￥电议型 号：T14153产 地：中国大陆
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T14152Akt1 and Akt2-IN-1；化合物 T14152Akt1 and Akt2-IN-1
Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM). It has potent and balanced activity.
价 格：￥电议型 号：T14152产 地：中国大陆
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T14151AKR1C1-IN-1；化合物AKR1C1-IN-1AKR1C1-IN-1
AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).
价 格：￥电议型 号：T14151产 地：中国大陆
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T1415Gemfibrozil；吉非罗齐CI-719|||Jezil|||Decrelip|||Lopid；吉非罗齐|||CI-719|||Jezil|||Decrelip|||Lopid
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels o
价 格：￥电议型 号：T1415产 地：中国大陆
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T14148AH 6809；6-异丙氧基-9-氧代氧杂蒽-2-羧酸AH 6809|||Prostaglandin Receptor|||AH-6809|||inhibit|||AH6809|||Inhibitor
AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). AH 6809 has a Ki of 350 nM for mouse EP2 receptor.
价 格：￥电议型 号：T14148产 地：中国大陆
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T14147Pelitrexol；化合物 T14147AG 2037；AG 2037
Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor.
价 格：￥电议型 号：T14147产 地：中国大陆
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T14146AGN 210676；化合物 T14146Simenepag；Simenepag
AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).
价 格：￥电议型 号：T14146产 地：中国大陆
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T14145AGN194204；化合物 T14145IRX4204|||NRX194204|||VTP 194204；IRX4204|||NRX194204|||VTP 194204
AGN194204 (IRX4204) is inactive against RAR and is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2].
价 格：￥电议型 号：T14145产 地：中国大陆
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T14144AGN-195183；化合物 T14144AGN-195183
AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ. IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.) Target: RARα agonist Compound 4(AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation. Compound 4 (AGN 195183) is currently in Phase I/IIA clinical trials in cancer patients. Compound 4 and ATRA inhibit growth of the human breast cancer cell
价 格：￥电议型 号：T14144产 地：中国大陆
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T14143AGN 194310；化合物 T14143VTP-194310；VTP-194310
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
价 格：￥电议型 号：T14143产 地：中国大陆
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T14142AGL-2263；化合物 T14142AGL-2263
AGL-2263 is a blocker of insulin receptor (IR)
价 格：￥电议型 号：T14142产 地：中国大陆
