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  • T14223Amino-PEG10-amine；化合物 T14223Amino-PEG10-amine

    Amino-PEG10-amine is a PEG-based PROTAC linker employed for the conjugation of two mono diethylstilbestrol (DES)-based ligands. This compound offers an alternative approach to the synthesis of highly selective and active ER antagonists, which are crucial for the advancement of endocrine therapy in breast cancer treatment[1].

    价 格：￥电议型 号：T14223产 地：中国大陆

  • T14222Amino-PEG1-C2-acid；化合物 T14222Amino-PEG1-C2-acid

    Amino-PEG1-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

    价 格：￥电议型 号：T14222产 地：中国大陆

  • T14221Amino-ethyl-SS-PEG3-NHBoc；化合物 T14221Amino-ethyl-SS-PEG3-NHBoc

    Amino-ethyl-SS-PEG3-NHBoc is a cleavable 3-unit PEG ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

    价 格：￥电议型 号：T14221产 地：中国大陆

  • T14220Amine-PEG3-Biotin；化合物Amine-PEG3-BiotinAmine-PEG3-Biotin

    Amine-PEG3-Biotin can be used as a signal amplification label.

    价 格：￥电议型 号：T14220产 地：中国大陆

  • T1422Nilvadipine；尼伐地平FK235|||FR34235|||ARC029；FK235|||FR34235|||尼伐地平|||ARC029

    Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.

    价 格：￥电议型 号：T1422产 地：中国大陆

  • T14219Aminaftone；化合物AminaftoneAminaphthone；Aminaphthone

    Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.

    价 格：￥电议型 号：T14219产 地：中国大陆

  • T14218Amicarbazone；胺唑草酮BAY314666|||BAY-MKH 3586；BAY314666|||胺唑草酮|||BAY-MKH 3586

    Amicarbazone (BAY-MKH3586; BAY314666) is a potent PSII inhibitor, disrupting photosynthetic electron transport by binding to the Qb domain of photosystem II. This broad-spectrum herbicide is effective through foliar and root application, showcasing rapid absorption and translocation. However, its effectiveness can be compromised by common PSII inhibitor resistance. With an IC50 value indicating high potency, amicarbazone leads to chlorosis, stunted growth, tissue necrosis, and death in sensitive

    价 格：￥电议型 号：T14218产 地：中国大陆

  • T14217AMG 579；化合物AMG 579AMG-579；AMG-579

    AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).

    价 格：￥电议型 号：T14217产 地：中国大陆

  • T14216AMG 837；化合物 T14216AMG 837

    AMG 837 is a partial GPR40 agonist with an EC50 value of 13 nM, showcasing 85% of the maximal activity displayed by DHA in standard assay conditions, indicating its high potency and selectivity in vitro. This compound excels as a GPR40 agonist with a notable pharmacokinetic profile, effectively stimulating insulin secretion in a glucose-dependent manner in rodents and demonstrating potent insulin secretion stimulation in MIN6 cells, with efficacy comparable to that observed in aequorin Ca2+-flux

    价 格：￥电议型 号：T14216产 地：中国大陆

  • T14215AMG 837 sodium salt；化合物 T14215AMG 837 sodium salt

    AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively). AMG 837 is a highly potent stimulator of insulin secr

    价 格：￥电议型 号：T14215产 地：中国大陆

  • T14214AMG 511；化合物AMG 511AMG 511

    AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease.

    价 格：￥电议型 号：T14214产 地：中国大陆

  • T14213Tapotoclax；化合物 T14213AMG-176；AMG-176

    AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).

    价 格：￥电议型 号：T14213产 地：中国大陆

  • T14212AMG-1694；化合物AMG-1694AMG-1694

    AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates G

    价 格：￥电议型 号：T14212产 地：中国大陆

  • T14211AMG-009；化合物 T14211AMG009|||AMG 009|||AMG009|||AMG-009|||AMG 009；AMG009|||AMG 009|||AMG009|||AMG-009|

    AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively.

    价 格：￥电议型 号：T14211产 地：中国大陆

  • T14210Amelubant；化合物 T14210BIIL 284；BIIL 284

    Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes.

    价 格：￥电议型 号：T14210产 地：中国大陆

  • T1421Aceclofenac；醋氯芬酸Preservex|||Airtal；醋氯芬酸|||Preservex|||Airtal

    Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.

    价 格：￥电议型 号：T1421产 地：中国大陆

  • T14209Amebucort；安布可特Amebucort

    Amebucort is a synthetic glucocorticoid corticosteroid. It may used for the research of inflammatory disorders.

    价 格：￥电议型 号：T14209产 地：中国大陆

  • T14208AMD 3465；化合物 T14208GENZ-644494；GENZ-644494

    AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.

    价 格：￥电议型 号：T14208产 地：中国大陆

  • T14207Amcinafal；安西法尔SQ 15102；安西法尔|||SQ 15102

    Amcinafal is an active diol,and used against virus replication and interferon production.

    价 格：￥电议型 号：T14207产 地：中国大陆

  • T14206Ambutonium bromide；化合物 T14206BL700；BL700

    Ambutonium bromide is an antagonist of acetylcholine.

    价 格：￥电议型 号：T14206产 地：中国大陆

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