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T28331PD 136450;化合物 T28331Cam1189|||PD136450|||Cam-1189|||PD-136450|||Cam 1189;Cam1189|||PD136450|||Cam-11
Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B)) receptor antagonists may help to elucidate the physiological role of gastrin, have therapeutic potential as acid antisecretory drugs, and may be of use as adjuvant therapy for gastrin sensitive tumours. The agonist effect of PD-136,450 is mediated via interaction with the gastrin (CCK-B) receptor in the stomach
价 格:¥电议型 号:T28331产 地:中国大陆
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T28011Megazol;化合物 T28011CL 64855|||CL-64855|||CL64855;CL 64855|||CL-64855|||CL64855
Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively.
价 格:¥电议型 号:T28011产 地:中国大陆
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T27990MDK-0738;化合物 T27990AKR1C3-IN-14a|||AKR1C3 IN 14a;AKR1C3-IN-14a|||AKR1C3 IN 14a
MDK-0738 is a potent and selective aldo-keto reductase 1C3 inhibitor.
价 格:¥电议型 号:T27990产 地:中国大陆
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T27968M-5011;化合物 T27968T-3788|||S-MTPPA|||M 5011|||M-5011C;T-3788|||S-MTPPA|||M 5011|||M-5011C
M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially inhibits the generalized bone loss accompanying the development of collagen-induced arthritis in rats. M-5011 is a useful NSAID that shows potent antinociceptive effects with low ulcerogenic activities.
价 格:¥电议型 号:T27968产 地:中国大陆
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T27626Irampanel;化合物 T27626BIIR-561CL;BIIR-561CL
Irampanel is a neuroprotectant and anticonvulsant.
价 格:¥电议型 号:T27626产 地:中国大陆
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T27331Flerobuterol HCl;化合物 T27331CRL-40996|||CRL40996|||CRL 40996|||Flerobuterol hydrochloride;CRL-40996||
Flerobuterol is a β adrenergic receptor agonist potentially for the treatment of major depressive disorder. Flerobuterol enhances serotonergic neurotransmission. Flerobuterol acutely increases 5-HT synthesis, in part, through an elevation of brain Trp availability.
价 格:¥电议型 号:T27331产 地:中国大陆
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T27111Cyslabdan;化合物 T27111Cyslabdan
Cyslabdan inhibits the synthesis of Pentaglycine Interpeptide Bridge.
价 格:¥电议型 号:T27111产 地:中国大陆
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T27101CV-3988;化合物 T27101CV 3988|||CV3988;CV 3988|||CV3988
CV-3988 is a specific antagonist of PAF-R (platelet-activating factor receptor)(Ki = 0.872 μM).
价 格:¥电议型 号:T27101产 地:中国大陆
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T27093CT-1;化合物CT-1CT 1;CT 1
CT-1 is a DNA minor groove ligand and causes p53-dependent breast cancer cell apoptosis.
价 格:¥电议型 号:T27093产 地:中国大陆
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T27081CRA-19156;化合物 T27081CRA19156;CRA19156
CRA-19156 is a potent HDAC8 inhibitor.
价 格:¥电议型 号:T27081产 地:中国大陆
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T27071CPI571;化合物 T27071CPI571
CPI571 is a potent and selective inhibitor for the bromodomains of CREBBP/EP300.
价 格:¥电议型 号:T27071产 地:中国大陆
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T27051CM-414;化合物 T27051CM 414|||CM414;CM 414|||CM414
CM-414 is a dual inhibitor of HDACs and PDE5 for the Treatment of Alzheimer’s Disease (IC50 values of 60 nM, 310 nM, 490 nM, 322 nM, and 91 nM against PDE5, HDAC1, HDAC2, HDAC3, and HDAC6, respectively). Chronic treatment of Tg2576 mice with CM-414 diminished brain Aβ and tau phosphorylation (pTau) levels, increased the inactive form of GSK3β, reverted the decrease in dendritic spine density on hippocampal neurons, and reversed their cognitive deficits, at least in part by inducing the expressio
价 格:¥电议型 号:T27051产 地:中国大陆
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T27048CLR-131;化合物 T27048131I-NM-404|||I 131 CLR 1404|||I-131-CLR-1404|||I-131CLR1404|||I 131CLR1404;131I-N
CLR-131, a protein kinase B (PKB) inhibitor, is used potentially for the treatment of non small cell lung cancer, solid tumors.
价 格:¥电议型 号:T27048产 地:中国大陆
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T27041Clidanac;化合物 T27041Clidanaco|||TAI 284|||Britai|||TAI-284|||TAI284;Clidanaco|||TAI 284|||Britai|||TA
Clidanac is a potent anti-inflammatory drug and is found to uncouple the oxidative phosphorylation.
价 格:¥电议型 号:T27041产 地:中国大陆
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T27021Cinitapride Tartrate;化合物 T27021Cinitapride Tartrate
Cinitapride Tartrate is an agonist of the 5-HT1 and 5-HT4 receptors and is also an antagonist of the 5-HT2 receptors.
价 格:¥电议型 号:T27021产 地:中国大陆
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T26981Ceralasertib formate;化合物 T26981Ceralasertib|||AZD-6738|||AZD 6738|||AZD6738;Ceralasertib|||AZD-6738|
Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.
价 格:¥电议型 号:T26981产 地:中国大陆
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T26971Ceclazepide;化合物 T26971Ceclazepide
Ceclazepide is an antagonist of cholecystokinin receptor.
价 格:¥电议型 号:T26971产 地:中国大陆
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T26961CBIP;化合物 T26961CBIP
CBIP is a small-molecule inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC). CBIP possesses low micromolar activity against BoNT/A.
价 格:¥电议型 号:T26961产 地:中国大陆
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T26521ABP-700;化合物 T26521CPMM;CPMM
ABP-700 is a positive allosteric modulator of the GABAA receptor.
价 格:¥电议型 号:T26521产 地:中国大陆