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  • T39440CXCL12 ligand 1;CXCL12 ligand 1CXCL12 ligand 1

    CXCL12 ligand 1 is the first ligand of the sY12-binding pocket on chemokine CXCL12 .

    价 格:¥电议型 号:T39440产 地:中国大陆

  • T39372CDK7-IN-1;CDK7-IN-1CDK7-IN-1;CDK7-IN-1

    CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound 215).

    价 格:¥电议型 号:T39372产 地:中国大陆

  • T39175CSP1;CSP1CSP1

    CSP1 is a highly potent and selective agonist of the ComD1 receptor, exhibiting an IC50 value of 10.3 nM. It represents a major variant of competence-stimulating peptide (CSP) and plays a crucial role in regulating the genetic transformation of S. pneumoniae through modulation of quorum sensing (QS). Additionally, CSP1 possesses antibacterial activity, further enhancing its potential as an effective antibacterial agent.

    价 格:¥电议型 号:T39175产 地:中国大陆

  • T39078CXCR7 antagonist-1;CXCR7拮抗剂1CXCR7 antagonist-1;CXCR7 antagonist-1

    CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7. CXCR7 antagonist-1 prevents tumor cell proliferation and tumor formation and can be used in studies about inflammatory diseases.

    价 格:¥电议型 号:T39078产 地:中国大陆

  • T38931Calpain Inhibitor-1;Calpain Inhibitor-1Calpain Inhibitor-1

    Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), which is a cysteine protease. It exhibits an IC50 value of 100 nM and a Ki value of 2.89 μM.

    价 格:¥电议型 号:T38931产 地:中国大陆

  • T38684AKR1C3-IN-4;化合物AKR1C3-IN-4AKR1C3-IN-4;AKR1C3-IN-4

    AKR1C3-IN-4 is a potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3) with an IC50 of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research.

    价 格:¥电议型 号:T38684产 地:中国大陆

  • T38619GSK1795091GSK1795091CRX-601

    GSK1795091 (CRX-601) is a synthetic TLR4 agonist and immunologic stimulator with demonstrated antitumor activity. It serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines.

    价 格:¥电议型 号:T38619产 地:中国大陆

  • T38598CBK289001;CBK289001CBK289001

    CBK289001 is a tartrate-resistant acid phosphatase (TRAP/ACP5) inhibitor. CBK289001 inhibits TRAP 5b MV , TRAP 5b OX and TRAP 5a OX with IC 50 s of 125 μM, 4.21 μM and 14.2 μM, respectively.

    价 格:¥电议型 号:T38598产 地:中国大陆

  • T38370CAY10731;CAY10731CAY10731

    CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).[1] Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.

    价 格:¥电议型 号:T38370产 地:中国大陆

  • T3822011-cis Retinol11-cis Retinol11 cis Retinol|||11cis Retinol

    11-cisRetinol is an isomer of vitamin A . It is formed from vitamin A,viaatrans-retinyl ester intermediate, by the enzyme RPE65 in the retinal pigment epithelium and then converted to 11-cis retinal as part of the visual cycle.1,211-cisRetinol is an agonist of salamander and human red rod opsins expressed in COS cells and an inverse agonist of salamander red cone opsin, as well as human red and green cone opsins expressed in COS cells.3It promotes pigment formation in cone, but not rod, photorec

    价 格:¥电议型 号:T38220产 地:中国大陆

  • T37832CAY10761;CAY10761CAY10761;CAY10761

    CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4

    价 格:¥电议型 号:T37832产 地:中国大陆

  • T37831CAY10641;CAY10641CAY10641

    Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from thesn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1CAY10641 is an inactive alcohol derivative of a highly potent (IC50= 12 nM) cPLA2α inhibitor.2The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in

    价 格:¥电议型 号:T37831产 地:中国大陆

  • T37792A2A receptor antagonist 1;化合物A2A receptor antagonist 1CPI-444 analog|||A2A receptor antagonist 1;CPI

    A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.

    价 格:¥电议型 号:T37792产 地:中国大陆

  • T37464CAY10711CAY10711CAY-10711|||CAY10711

    CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse ef

    价 格:¥电议型 号:T37464产 地:中国大陆

  • T37424CAY10781;化合物CAY10781CAY10781;CAY10781

    CAY10781 is an inhibitor of the protein-protein interaction between neuropilin-1 (NRP-1) and VEGF-A.1It inhibits the interaction by 43% when used at a concentration of 12.5 μM. CAY10781 also inhibits VEGF-A-induced phosphorylation of VEGFR2 in catecholamine A-differentiated (CAD) cells when used at the same concentration.

    价 格:¥电议型 号:T37424产 地:中国大陆

  • T37414CAY10771CAY10771CAY-10771|||CAY10771

    CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM.

    价 格:¥电议型 号:T37414产 地:中国大陆

  • T37356Cbl-b-IN-1;Cbl-b抑制剂1Cbl-b-IN-1

    Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.

    价 格:¥电议型 号:T37356产 地:中国大陆

  • T36848Combretastatin A-1;康普瑞汀A-1Combretastatin A1;Combretastatin A1

    Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated inactivation of AKT to inhibit the Wnt/β-catenin pathway, and can be used to study hepatocellular carcinoma.

    价 格:¥电议型 号:T36848产 地:中国大陆

  • T36744CDK9 Antagonist-1;CDK9 Antagonist-1CDK9 Antagonist-1;CDK9 Antagonist-1

    CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].

    价 格:¥电议型 号:T36744产 地:中国大陆

  • T36672CAY10561;CAY10561CAY10561

    The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561

    价 格:¥电议型 号:T36672产 地:中国大陆

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