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  • T60661CP681301；化合物 CP681301CP681301

    CP681301 is a potent inhibitor of CDK5 with antiproliferative activity. CP681301 exhibits anti-tumor activity in Drosophila. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in Glioma stem cells (GSCs). CP681301 reduces self-renewal in mouse glioma xenografts [1].

    价 格：￥电议型 号：T60661产 地：中国大陆

  • T60630COX/5-LOX-IN-1；化合物 COX/5-LOX-IN-1COX/5-LOX-IN-1

    COX/5-LOX-IN-1 (compound 6b) is a potent COX/5-LOX dual inhibitor with the potential for inflammation diseases research. COX/5-LOX-IN-1 has IC50s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectively [1].

    价 格：￥电议型 号：T60630产 地：中国大陆

  • T60583CDK1/2/4-IN-1；化合物 CDK1/2/4-IN-1CDK1/2/4-IN-1

    CDK1/2/4-IN-1 (compound 3a) is a potent inhibitor of CDK with IC 50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 can be used in cancer research. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates the level of Bax, caspase-3, and P53 and decreases the level of Bcl-2 [1].

    价 格：￥电议型 号：T60583产 地：中国大陆

  • T60579CEase-IN-1；化合物 CEase-IN-1CEase-IN-1

    CEase-IN-1 (Compound A1H3) is a potent and selective inhibitor of cholesterol esterase (CEase) with an IC 50 of 0.36 μM. It can be used in hypercholesterolemia research [1].

    价 格：￥电议型 号：T60579产 地：中国大陆

  • T60515CaMKIIα-IN-1；化合物 CaMKIIα-IN-1CaMKIIα-IN-1

    CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 shows good metabolic stability [1].

    价 格：￥电议型 号：T60515产 地：中国大陆

  • T60457COX-2-IN-11；化合物 COX-2-IN-11COX-2-IN-11

    COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].

    价 格：￥电议型 号：T60457产 地：中国大陆

  • T6042[11C]MP 10；化合物PF-2545920Mardepodect|||PF-2545920；Mardepodect|||PF-2545920

    [11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.

    价 格：￥电议型 号：T6042产 地：中国大陆

  • T60416CRM1 degrader 1；化合物 CRM1 degrader 1CRM1 degrader 1

    CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].

    价 格：￥电议型 号：T60416产 地：中国大陆

  • T60403COX-2/NO-IN-1；化合物 COX-2/NO-IN-1COX-2/NO-IN-1

    COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO ( IC 50 of 3.52 μM) inhibitor as well as suppresses the expression of COX-2. COX-2/NO-IN-1 has anti-inflammatory effects and reduces pathological damage to kidney tissues[1].

    价 格：￥电议型 号：T60403产 地：中国大陆

  • T60380CS1；化合物 CS1CS1

    CS1 is a potent DNA Topo II α inhibitor. CS1 exhibits broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 causes DNA damage, cell cycle arrest at G2/M phase, and apoptosis [1].

    价 格：￥电议型 号：T60380产 地：中国大陆

  • T60336CCR4 antagonist 3-1；CCR4拮抗剂3-1CCR4 antagonist 3-1

    CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of radiolabeled [125I]TARC and macrophage-derived chemokine ( MDC) to CEM cell surface and inhibits TARC-mediated CEM cell migration in vitro with an IC50 value of 6.4 μM. CCR4 antagonist 3 inhibited the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to the

    价 格：￥电议型 号：T60336产 地：中国大陆

  • T60303Collagen-IN-1；化合物 Collagen-IN-1Collagen-IN-1

    Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Collagen-IN-1 effectively reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelets. This compound holds promise for research into platelet-related thrombosis diseases [1].

    价 格：￥电议型 号：T60303产 地：中国大陆

  • T60262Cholera autoinducer 1；化合物 Cholera autoinducer 1Cholera autoinducer 1

    Cholera autoinducer 1 is an autoinducer of Vibrio cholerae. Cholera autoinducer 1 influences chemotaxis in C. elegans [1].

    价 格：￥电议型 号：T60262产 地：中国大陆

  • T6015Cathepsin Inhibitor 1；化合物Cathepsin Inhibitor 1Cathepsin Inhibitor 1

    Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

    价 格：￥电议型 号：T6015产 地：中国大陆

  • T60145CCR6 antagonist 1；CCR6拮抗剂1CCR6 antagonist 1

    CCR6 antagonist 1, a chemical compound acting as a CCR6 antagonist, effectively inhibits the CCL20/CCR6 axis. Its utility lies in research focused on autoimmune-mediated inflammatory diseases, including inflammatory bowel diseases (IBDs).

    价 格：￥电议型 号：T60145产 地：中国大陆

  • T60095CCF0058981；化合物CCF0058981CCF0058981

    CCF0058981 (CCF981) is a 3-chlorophenyl analogue, serving as a noncovalent inhibitor of SARS-CoV-2 3CL pro (SC2), demonstrating potent activity with an IC50 of 68 nM. It also exhibits inhibitory effects against SARS-CoV-1 3CL pro (SC1) with an IC50 of 19 nM, highlighting its antiviral efficacy and potential in COVID-19 research [1].

    价 格：￥电议型 号：T60095产 地：中国大陆

  • T5347CXD101；化合物CXD-101CXD-101；CXD-101

    CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II

    价 格：￥电议型 号：T5347产 地：中国大陆

  • T50083Cell-cell interaction 1；化合物 Cell-cell interaction 1Cell-cell interaction 1

    12-oxo-N-[1-(propan-2-yl)piperidin-4-yl]-6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide available as a molecular structural unit, it is used in the synthesis of various compounds.

    价 格：￥电议型 号：T50083产 地：中国大陆

  • T50011CYP2A6-IN-1；CYP2A6 抑制剂 1CYP2A6-IN-1

    (2-methylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amine is a selective serotonin receptor agonist that specifically targets 5-HT2A and 5-HT2C receptors. It has been used to study the role of serotonin in a variety of physiologic and pathologic conditions.

    价 格：￥电议型 号：T50011产 地：中国大陆

  • T4482CC-671；化合物CC-671CC-671

    CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.

    价 格：￥电议型 号：T4482产 地：中国大陆

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