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  • T61742CDK8-IN-11；化合物 CDK8-IN-11CDK8-IN-11

    CDK8-IN-11 is a potent and selective inhibitor of CDK8, demonstrating an IC50 of 46 nM, and effectively targets the WNT/β-catenin signaling pathway. This compound has potential applications in colon cancer research [1].

    价 格：￥电议型 号：T61742产 地：中国大陆

  • T61674COX-2/5-LOX-IN-1；化合物 COX-2/5-LOX-IN-1COX-2/5-LOX-IN-1

    COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 displays strong inhibitory activity against COX-1, COX-2, and 5-LOX, with IC50 values of 12.13 μM, 0.4 μM, and 4.96 μM, respectively [1].

    价 格：￥电议型 号：T61674产 地：中国大陆

  • T61583CDK/HDAC-IN-1；化合物 CDK/HDAC-IN-1CDK/HDAC-IN-1

    CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively.

    价 格：￥电议型 号：T61583产 地：中国大陆

  • T61543CLK1/4-IN-1；化合物 CLK1/4-IN-1CLK1/4-IN-1

    CLK1/4-IN-1 (compound 31) is a highly potent and selective inhibitor of Clk1 and Clk4, with IC50 values of 9.7 nM and 6.6 nM, respectively. It effectively inhibits the growth of T24 cancer cells, with a GI50 value of 1.1 μM. CLK1/4-IN-1 has shown promising potential as an anticancer research tool [1].

    价 格：￥电议型 号：T61543产 地：中国大陆

  • T61380Carpro-AM1；化合物 Carpro-AM1Carpro-AM1

    Carpro-AM1 is a compound that acts as a dual inhibitor of both fatty acid amide hydrolase (FAAH) and substrate-selective cyclooxygenase (COX). It exhibits potent inhibitory activity against FAAH, with an IC50 value of 94 nM [1].

    价 格：￥电议型 号：T61380产 地：中国大陆

  • T61328CO delivery molecule 1；化合物 CO delivery molecule?1CO delivery molecule 1

    CO delivery molecule 1 (compound 4) exhibits subcellular localization in the endoplasmic reticulum, mitochondria, and lysosomes. Such localization leads to the manifestation of CO-induced toxicity effects. Notably, the anti-inflammatory properties of CO delivery molecule 1, quantified through TNF-α suppression, are evident at nanomolar concentrations even without CO release. Furthermore, visible-light-induced CO release further enhances its anti-inflammatory effects [1].

    价 格：￥电议型 号：T61328产 地：中国大陆

  • T61301Chromenone 1；化合物Chromenone 1Chromenone 1

    Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.

    价 格：￥电议型 号：T61301产 地：中国大陆

  • T61292CAII-IN-1；化合物 CAII-IN-1CAII-IN-1

    CAII-IN-1 (compound 3n) is a thiosemicarbazide derivative that acts as a potent and selective inhibitor of carbonic anhydrase-II (CA-II), with an IC50 value of 10.3 μM for bovine CA-II. This compound (CAII-IN-1) finds utility in research pertaining to carbonic anhydrase-associated biological disorders [1].

    价 格：￥电议型 号：T61292产 地：中国大陆

  • T61287CYP121A1-IN-1；化合物 CYP121A1-IN-1CYP121A1-IN-1

    CYP121A1-IN-1 is a potent inhibitor of CYP121A1, demonstrating favorable activity against Mycobacterium tuberculosis (H37Rv MIC 90 ~6.25 μM, ~2.2 μg/mL). It significantly reduces mycocyclosin production by blocking the CYP121A1-mediated conversion of cyclo(l-tyrosyl-l-tyrosyl) to mycocyclosin [1].

    价 格：￥电议型 号：T61287产 地：中国大陆

  • T61254CDK1/Cyc B-IN-1；化合物 CDK1/Cyc B-IN-1CDK1/Cyc B-IN-1

    CDK1/Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1/Cyc B complex, demonstrating selectivity with an IC50 value of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest, effectively halting cancer cell proliferation. Additionally, CDK1/Cyc B-IN-1 exhibits a wide-ranging cytotoxic effect on various cancer cell lines [1].

    价 格：￥电议型 号：T61254产 地：中国大陆

  • T61196COX-1/2-IN-1；化合物 COX-1/2-IN-1COX-1/2-IN-1

    COX-1/2-IN-2, a potent inhibitor of both COX-1 and COX-2, demonstrates significant inhibitory activity, with IC50 values of 13.9 ± 3.21 μM for COX-1 and 6.4 ± 0.74 μM for COX-2, respectively [1].

    价 格：￥电议型 号：T61196产 地：中国大陆

  • T61053CD73-IN-11；化合物 CD73-IN-11CD73-IN-11

    CD73-IN-11 is able to used for tumor-related diseases medicament preparing. CD73-IN-11 is an effective CD73 inhibitor. CD73 can catalyze the production of adenosine from extracellular 5´-phosphate adenosine (5´-AMP) which induce immunosuppression and promote tumor proliferation and/or metastasis [1].

    价 格：￥电议型 号：T61053产 地：中国大陆

  • T61026CaV1.3 antagonist-1；化合物 CaV1.3 antagonist-1CaV1.3 antagonist-1

    CaV1.3 antagonist-1 is a cyclopentyl derivative with the potential for the research of Parkinson´s disease. CaV1.3 antagonist-1 inhibits Ca V 1.3 LTCC over 600-fold more effectively than Ca V 1.2 LTCC. CaV1.3 antagonist-1 is a potent and highly selective antagonist of Ca V 1.3 L-type calcium channel (LTCC) with an IC50 value of 1.7 μM [1].

    价 格：￥电议型 号：T61026产 地：中国大陆

  • T61009Complex III-IN-1；化合物 Complex III-IN-1Complex III-IN-1

    Complex III-IN-1 (Compd 4c-2) is an inhibitor of complex III with antifungal activity. The EC50 value of Complex III-IN-1 against sclerotinia sclerotiorum is 18.53 mg/L [1].

    价 格：￥电议型 号：T61009产 地：中国大陆

  • T60940ChE/Aβ1-42-IN-1；化合物 ChE/Aβ1-42-IN-1ChE/Aβ1-42-IN-1

    ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability. The IC50 values of ChE/Aβ1-42-IN-1 for AChE, BuChE and Aβ 1-42 aggregation are 0.062, 0.767 and 1.227 μM, respectively. ChE/Aβ1-42-IN-1 is a potent multi-targeted anti-Alzheimer´s disease agent [1].

    价 格：￥电议型 号：T60940产 地：中国大陆

  • T60930CAXII-IN-1；化合物 CAXII-IN-1CAXII-IN-1

    CAXII-IN-1 (Compound 17) has antitumor activity that is a selective inhibitor of CA XII. The Ki values of CAXII-IN-1 for hCA XII and hCA IX is 3.8 nM and 56.0 nM, respectively [1].

    价 格：￥电议型 号：T60930产 地：中国大陆

  • T6091CP-673451；化合物CP673451CP-673451

    CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiogenic receptors.

    价 格：￥电议型 号：T6091产 地：中国大陆

  • T60812Cathepsin X-IN-1；化合物Cathepsin X-IN-1Cathepsin X-IN-1

    Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].

    价 格：￥电议型 号：T60812产 地：中国大陆

  • T60796Cholesterol 24-hydroxylase-IN-1；Cholesterol 24-hydroxylase 抑制剂 1Cholesterol 24-hydroxylase-IN-1

    Cholesterol 24-hydroxylase-IN-1 is an orally active, selective, and potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) that crosses the blood-brain barrier.Cholesterol 24-hydroxylase-IN-1 may be useful in the study of epilepsy-like neurological disorders. Cholesterol 24-hydroxylase-IN-1 is used to study epilepsy-like neurological diseases.

    价 格：￥电议型 号：T60796产 地：中国大陆

  • T60723CYP1B1-IN-1；化合物 CYP1B1-IN-1CYP1B1-IN-1

    CYP1B1-IN-1 (Compound 9e) is a selective inhibitor of cytochrome P450 1B1 (CYP1B1) (IC 50 = 0.49 nM) [1].

    价 格：￥电议型 号：T60723产 地：中国大陆

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