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T76734CTX-471；化合物 CTX-471CTX-471
CTX-471, a fully human monoclonal antibody targeting CD137, exhibits binding affinity for CD137 across multiple species, including humans, cynomolgus macaques, and mice, with dissociation constant (Kd) values of 50 nM, 61 nM, and 748 nM, respectively. This compound is utilized in the study of immunomodulation and cancer research [1].
价 格：￥电议型 号：T76734产 地：中国大陆
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T76571Caspase-8-IN-1；化合物 Caspase-8-IN-1Caspase-8-IN-1
Caspase-8-IN-1 is a potent caspase-8 inhibitor [1] .
价 格：￥电议型 号：T76571产 地：中国大陆
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T76254CD31；化合物 CD31CD31
CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a receptor on endothelial cells for clostridium perfringens beta-Toxin (CPB). It also functions as an ER-MP12 antigen and connects mechanical stress, metabolism, and inflammation. The CD31 peptide promotes phosphorylation of CD31 ITIM 686 and SHP2, thereby inhibiting TCR-induced T-cell activation [1]-[5].
价 格：￥电议型 号：T76254产 地：中国大陆
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T75435cis-Vitamin K1；化合物 cis-Vitamin K1cis-Vitamin K1
Cis-Vitamin K1 is an endogenous metabolite of Vitamin K [1] .
价 格：￥电议型 号：T75435产 地：中国大陆
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T75121CDK7-IN-21；化合物 CDK7-IN-21CDK7-IN-21
CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .
价 格：￥电议型 号：T75121产 地：中国大陆
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T74965CypE-IN-1；化合物 CypE-IN-1CypE-IN-1
CypD-IN-1, a potent and subtype-selective inhibitor targeting cyclophilin E (CypE), demonstrates high affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. This compound is valuable for research into various conditions, including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy, and diabetes [1].
价 格：￥电议型 号：T74965产 地：中国大陆
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T74816Complement C1s-IN-1；化合物 Complement C1s-IN-1Complement C1s-IN-1
Complement C1s-IN-1 is a potent and selective C1s inhibitor that is orally active and capable of crossing the blood-brain barrier, demonstrating an IC50 value of 36 nM [1].
价 格：￥电议型 号：T74816产 地：中国大陆
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T74604CB2R probe 1；化合物 CB2R probe 1CB2R probe 1
CB2R Probe 1, a cannabinoid 2 receptor (CB2R) fluorescent probe, exhibits both safety and environmental friendliness, boasting a dissociation constant (K i) of 130 nM. Notably, it demonstrates low cytotoxicity within cancer cells [1].
价 格：￥电议型 号：T74604产 地：中国大陆
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T74492CD22 ligand-1；化合物 CD22 ligand-1CD22 ligand-1
CD22 Ligand-1 (Compound 12) is a potent, selective ligand for CD22, exhibiting dissociation constants (K_D) of 0.335 ?M for human CD22 (hCD22) and 30.7 ?M for myelin-associated glycoprotein (MAG), indicating specificity towards hCD22. This ligand holds potential for B-cell related disease research [1].
价 格：￥电议型 号：T74492产 地：中国大陆
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T74370CDK4/6-IN-11；化合物 CDK4/6-IN-11CDK4/6-IN-11
CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader.
价 格：￥电议型 号：T74370产 地：中国大陆
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T7406AKR1C3-IN-13-(3,4-二氢-1H-异喹啉-2-磺酰基)-苯甲酸3-(3,4-二氢-1H-异喹啉-2-磺酰基)-苯甲酸
AKR1C3-IN-1 is a potent and selective inhibitor of AKR1C3(IC50 of 13 nM).
价 格：￥电议型 号：T7406产 地：中国大陆
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T73547CPUL1；化合物 CPUL1CPUL1
CPUL1, a TrxR inhibitor, exhibits proliferation-inhibitory and anti-metastatic effects on A549 cells by modulating epithelial-mesenchymal transition (EMT) through the induction of ROS-mediated ERK/JNK signaling, achieved by inhibiting TrxR1 enzyme activity. The efficacy of CPUL1 is enhanced when used in conjunction with α-Lipoic Acid or Dithiodipropionic acid [1].
价 格：￥电议型 号：T73547产 地：中国大陆
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T73449CZS-241；化合物 CZS-241CZS-241
CZS-241 is an orally active, selective Polo-like Kinase (PLK) 4 inhibitor with an IC 50 of 2.6 nM that also inhibits TRKA at an IC 50 of 2.74 μM. It induces apoptosis and causes cell cycle arrest at the S/G2 phase, demonstrating potent antiproliferative effectiveness against leukemia cell lines while maintaining safety towards normal cell lines.
价 格：￥电议型 号：T73449产 地：中国大陆
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T73417Con B-1；化合物 Con B-1Con B-1
ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells [1] .
价 格：￥电议型 号：T73417产 地：中国大陆
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T73413Cadein1；化合物 Cadein1Cadein1
Cadein1, an isoquinolinium derivative, induces G2/M phase delay and caspase-dependent apoptosis in cancer cells lacking functional p53.
价 格：￥电议型 号：T73413产 地：中国大陆
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T73351CAY10581；化合物 CAY10581CAY10581
CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50 value of 55 nM.
价 格：￥电议型 号：T73351产 地：中国大陆
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T73274CamA-IN-1；CamA-IN-1CamA-IN-1
CamA-IN-1 is a Clostridioides difficile -specific DNA adenine methyltransferase (CamA) inhibitor. CamA-IN-1 has inhibitory for CamA with IC 50 and K d values of 0.4 μM and 0.2 μM, respectively. CamA-IN-1 can be used for the research of Clostridioides difficile infections (CDI) [1] .
价 格：￥电议型 号：T73274产 地：中国大陆
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T73269CK2α-IN-1；CK2α抑制剂1CK2α-IN-1
CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 ?M and a Ki of 1.6 ?M.CK2α-IN-1 exhibits potential anticancer activity and can be used in cancer research.
价 格：￥电议型 号：T73269产 地：中国大陆
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T73261C5aR-IN-1；化合物 C5aR-IN-1C5aR-IN-1
C5aR-IN-1, a potent inhibitor of C5aR, is linked with the potential to research inflammatory diseases. This association is due to the elevated levels of C5a, which are connected with autoimmune and inflammatory disorders.
价 格：￥电议型 号：T73261产 地：中国大陆
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T73221CASK-IN-1；化合物 CASK-IN-1CASK-IN-1
CASK-IN-1 is a highly potent and selective CASK inhibitor with a K d value of 0.022 μM.
价 格：￥电议型 号：T73221产 地：中国大陆
