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  • T82715Cisplatin-resistant cells-IN-1；化合物 Cisplatin-resistant cells-IN-1Cisplatin-resistant cells-IN-1

    Cisplatin-resistant cells-IN-1 (Compound 8) exhibits high cytotoxicity against Cisplatin-resistant cells and effectively diminishes metabolic activity at low nanomolar concentrations, with an IC50 ranging from 0.14 to 1.79 μM in various resistant cell lines, including A549/A549-R, K562/K562-R, and MCF-7/MCF-7TamR [1].

    价 格：￥电议型 号：T82715产 地：中国大陆

  • T82713Ciwujianoside C1；化合物 Ciwujianoside C1Ciwujianoside C1

    Ciwujianoside C1, a saponin derived from the leaves of Acanthopanax senticosus, exhibits in vitro inhibition of pancreatic lipase activity [1].

    价 格：￥电议型 号：T82713产 地：中国大陆

  • T82703CMKLR1 antagonist 1；化合物 CMKLR1 antagonist 1CMKLR1 antagonist 1

    CMKLR1 antagonist 1 (compound S-26d) is a potent, orally active antagonist of the chemokine-like receptor 1 (CMKLR1), exhibiting a pIC50 of 7.44 in hCMKLR1-transfected CHO cells. It is applicable in the research of psoriasis and metabolic diseases [1].

    价 格：￥电议型 号：T82703产 地：中国大陆

  • T82693Combi-1；化合物 Combi-1Combi-1

    Combi-1 is an antimicrobial peptide exhibiting broad-spectrum efficacy against various bacterial and yeast strains [1].

    价 格：￥电议型 号：T82693产 地：中国大陆

  • T82635Cy-FBP/SBPase-IN-1；化合物 Cy-FBP/SBPase-IN-1Cy-FBP/SBPase-IN-1

    Cy-FBP/SBPase-IN-1 (compound S5) serves as an inhibitor of the key regulatory enzyme Cy-FBP/SBPase in cyanobacterial photosynthesis, impeding the Calvin cycle and photosystem, thereby reducing photosynthetic efficiency. It effectively suppresses the proliferation of cyanobacteria, including Synechocystis sp. PCC6803, while demonstrating a safe profile in human-derived cell lines and zebrafish models [1].

    价 格：￥电议型 号：T82635产 地：中国大陆

  • T81823Mem-C1C18；化合物 Mem-C1C18Mem-C1C18

    Mem-C1C18, a polarity-sensitive fluorescent probe, exhibits superior plasma membrane anchoring and high brightness, alongside a sensitive alteration in fluorescence lifetime in response to environmental polarity changes. This compound facilitates the quantification of plasma membrane polarity fluctuations during ferroptosis [1].

    价 格：￥电议型 号：T81823产 地：中国大陆

  • T80469Citrullinated LL-37 1cit；化合物 Citrullinated LL-37 1citCitrullinated LL-37 1cit

    Citrullinated LL-37 1cit, a modified LL-37 peptide, retains the antiviral properties of its parent compound against human rhinovirus and exhibits antibacterial activity against S. aureus. Furthermore, it diminishes the RV1B-induced expression of pro-inflammatory cytokines, including IL-8, CCL5, and IL-6 mRNA [1].

    价 格：￥电议型 号：T80469产 地：中国大陆

  • T80452Ceratotoxin-1；化合物 Ceratotoxin-1CcoTx1|||β-TRTX-cm1a；CcoTx1|||β-TRTX-cm1a

    Ceratotoxin-1 (CcoTx1) is a peptide toxin that functions as an inhibitor of various voltage-gated sodium channel subtypes. It selectively inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC50 values of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Additionally, Ceratotoxin-1 is known to inhibit Nav1.8/β1 [1].

    价 格：￥电议型 号：T80452产 地：中国大陆

  • T80379Cyclopetide 1；化合物 Cyclopetide 1Cyclopetide 1

    Cyclopeptide 1 (Compound 1) is an antimicrobial peptide exhibiting moderate efficacy in inhibiting B. subtilis, presenting a minimum inhibitory concentration (MIC) of 25 μg/mL [1].

    价 格：￥电议型 号：T80379产 地：中国大陆

  • T80255CHRG01；化合物 CHRG01CHRG01

    CHRG01, a biologically active peptide, originates from the C-terminal amino acids 54 to 67 of human β-defensin 3 (hBD-3), with a modified structure wherein all cysteine (Cys) residues are replaced by serine (Ser) to eliminate disulfide bond linkages. Like its parent compound hBD-3, CHRG01 exhibits antimicrobial properties that are dependent on electrostatic interactions.

    价 格：￥电议型 号：T80255产 地：中国大陆

  • T80247Caloxin 3A1；化合物 Caloxin 3A1Caloxin 3A1

    Caloxin 3A1, a biologically active peptide, is a member of the caloxins, which are inhibitors of the extracellular plasma membrane (PM) Ca2+ pumps. Specifically, it inhibits plasma membrane calcium pumps (PMCAs) without affecting the sarcoplasmic reticulum Ca2+ pump, nor does it inhibit the formation of the acylphosphate intermediate from ATP.

    价 格：￥电议型 号：T80247产 地：中国大陆

  • T80208Tripeptide-41；化合物 Tripeptide-41CG-Lipoxyn；CG-Lipoxyn

    Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation. It has been utilized as an ingredient in cosmetic formulations [1].

    价 格：￥电议型 号：T80208产 地：中国大陆

  • T79987Cangorinine E-1；化合物 Cangorinine E-1Cangorinine E-1

    Cangorinine E-1 (compound 11), a dihydroagarofuran sesquiterpenoid derivative, exhibits weak inhibitory effects on herpes simplex virus type II (HSV) [1].

    价 格：￥电议型 号：T79987产 地：中国大陆

  • T79898Cbl-b-IN-11；化合物 Cbl-b-IN-11Cbl-b-IN-11

    Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of 6.4 nM and 6.1 nM, respectively [1].

    价 格：￥电议型 号：T79898产 地：中国大陆

  • T79793CRF1 receptor antagonist-1；化合物 CRF1 receptor antagonist-1CRF1 receptor antagonist-1

    CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].

    价 格：￥电议型 号：T79793产 地：中国大陆

  • T79743Caspase-3 activator 1；化合物 Caspase-3 activator 1Caspase-3 activator 1

    Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage. This cleavage enables Caspase-3 to process gasdermin E (GSDME), which results in the production of the GSDME-N terminus, leading to perforation of the gastric tumor cell membrane. Furthermore, compound 4b induces pyroptosis and subsequent immune responses. It can be incorporated with decitabine (DCT) into the 4b-DCT-Lip lipid delivery system [1].

    价 格：￥电议型 号：T79743产 地：中国大陆

  • T79741CARM1 degrader-1；化合物 CARM1 degrader-1CARM1 degrader-1

    PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1). This compound facilitates the degradation of CARM1 via the VHL-proteasome pathway. By degrading CARM1, PROTAC CARM1 degrader-1 effectively reduces the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, subsequently inhibiting breast cancer cell migration [1].

    价 格：￥电议型 号：T79741产 地：中国大陆

  • T79738CYP51/PD-L1-IN-1；化合物 CYP51/PD-L1-IN-1CYP51/PD-L1-IN-1

    CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM). This compound prompts early apoptosis in the fungal cell cycle, markedly diminishes intracellular IL-2, NLRP3, and NF-κBp65 protein concentrations, causes mitochondrial damage and ROS accumulation, and culminates in fungal lysis and cell death [1].

    价 格：￥电议型 号：T79738产 地：中国大陆

  • T79654CRM1-IN-1；化合物 CRM1-IN-1CRM1-IN-1

    CRM1-IN-1 (Compound KL1), a noncovalent inhibitor of CRM1, promotes nuclear degradation of CRM1 with an IC50 of 0.27 μM, inhibits CRM1-mediated nuclear export, suppresses cell proliferation, and induces apoptosis in colorectal cancer cells [1].

    价 格：￥电议型 号：T79654产 地：中国大陆

  • T79649CB1R/AMPK modulator 1；化合物 CB1R/AMPK modulator 1CB1R/AMPK modulator 1

    Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound activates AMPK and has been shown to decrease food intake and body weight, in addition to enhancing glucose tolerance and insulin sensitivity [1].

    价 格：￥电议型 号：T79649产 地：中国大陆

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