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  • T79637CIAC001；化合物 CIAC001CIAC001

    CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically active BV-2 cells with an IC50 value of 2.5 μM. Additionally, CIAC001 demonstrates anti-neuroinflammation effects in mouse models and attenuates chronic morphine-induced addiction [1].

    价 格：￥电议型 号：T79637产 地：中国大陆

  • T79577CB2 PET Radioligand 1；化合物 CB2 PET Radioligand 1CB2 PET Radioligand 1

    CB2 PET Radioligand 1 (compound [18F]9) is a positron emission tomography (PET) radioligand with high affinity for the human cannabinoid receptor 2 (hCB2, Ki=7.7 nM). It is synthesized via Cu-mediated 18F-fluorination and demonstrates significant brain uptake in a mouse model of neuroinflammation [1].

    价 格：￥电议型 号：T79577产 地：中国大陆

  • T79438c-Myc inhibitor 11；化合物 c-Myc inhibitor 11c-Myc inhibitor 11

    c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in rat pharmacokinetic assays, making it suitable for cancer research [1].

    价 格：￥电议型 号：T79438产 地：中国大陆

  • T79433AKR1C3-IN-10；化合物 AKR1C3-IN-10AKR1C3-IN-10

    AKR1C3-IN-10 (compound 5r), a selective inhibitor of AKR1C3 with an IC50 of 51 nM, demonstrates efficacy in a prostate cancer xenograft model [1].

    价 格：￥电议型 号：T79433产 地：中国大陆

  • T79395CBP/p300-IN-21；化合物 CBP/p300-IN-21CBP/p300-IN-21

    CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits the growth of 4T1 tumors in mice [1].

    价 格：￥电议型 号：T79395产 地：中国大陆

  • T79168CBP-IN-1；化合物 CBP-IN-1CBP-IN-1

    CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nM and 3100 nM, respectively [1].

    价 格：￥电议型 号：T79168产 地：中国大陆

  • T79088Chlamydia pneumoniae-IN-1；化合物 Chlamydia pneumoniae-IN-1Chlamydia pneumoniae-IN-1

    Chlamydia pneumoniae-IN-1 (compound 55), a benzimidazole derivative, exhibits potent antibacterial activity, inhibiting 99% of C. pneumoniae growth at a concentration of 10 μM and maintaining 95% viability of the host cells at the same concentration. It effectively inhibits the CV-6 strain of C. pneumoniae with a minimum inhibitory concentration (MIC) of 12.6 μM, demonstrating its antichlamydial efficacy [1].

    价 格：￥电议型 号：T79088产 地：中国大陆

  • T79059CXCR4-IN-1；化合物 CXCR4-IN-1CXCR4-IN-1

    CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic retinopathy, and inflammation [1].

    价 格：￥电议型 号：T79059产 地：中国大陆

  • T79023CaSR antagonist-1；化合物 CaSR antagonist-1CaSR antagonist-1

    CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation of diseases related to dysregulated bone or mineral homeostasis, including osteoporosis [1].

    价 格：￥电议型 号：T79023产 地：中国大陆

  • T78858cGAS-IN-1；化合物 cGAS-IN-1cGAS-IN-1

    cGAS-IN-1 (compound C20), a flavonoid that acts as a Cyclic GMP-AMP Synthase (cGAS) inhibitor, demonstrates IC50 values of 2.28 μM for human cGAS and 1.44 μM for mouse cGAS. By inhibiting the abnormal activation of cGAS linked to numerous immune-mediated inflammatory diseases, cGAS-IN-1 possesses potential anti-inflammatory properties [1].

    价 格：￥电议型 号：T78858产 地：中国大陆

  • T78814COH1；化合物 COH1COH1

    COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].

    价 格：￥电议型 号：T78814产 地：中国大陆

  • T78813CDK2/Bcl2-IN-1；化合物 CDK2/Bcl2-IN-1CDK2/Bcl2-IN-1

    CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells. Additionally, it inhibits Bcl-2 and promotes apoptosis in A549 lung cancer cells [1].

    价 格：￥电议型 号：T78813产 地：中国大陆

  • T78706COX-2-IN-31；化合物 COX-2-IN-31COX-2-IN-31

    COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM). This compound demonstrates anti-inflammatory and analgesic activity [1].

    价 格：￥电议型 号：T78706产 地：中国大陆

  • T78605CpCDPK1/TgCDPK1-IN-1；CpCDPK1/TgCDPK1抑制剂1CpCDPK1/TgCDPK1-IN-1

    CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections and cryptosporidiosis.

    价 格：￥电议型 号：T78605产 地：中国大陆

  • T78596CAD031；化合物 CAD031CAD031

    CAD031, a more active derivative of the Alzheimer´s disease (AD) targeting agent J147, exhibits neuroprotective and memory-enhancing properties. It has been shown to enhance memory, improve dendritic structure, and stimulate cell division in the germinal zone of aged mice brains. Additionally, CAD031 demonstrates greater efficacy than J147 in human neural stem cell assays [1].

    价 格：￥电议型 号：T78596产 地：中国大陆

  • T78204CYP11A1-IN-1；化合物 CYP11A1-IN-1CYP11A1-IN-1

    CYP11A1-IN-1 (compound 30) is a selective inhibitor of the enzyme CYP11A1, displaying an IC50 ranging from 201-2000 nM. It is applicable in the study of steroid receptor-mediated diseases, specifically targeting the androgen receptor for conditions like prostate cancer [1].

    价 格：￥电议型 号：T78204产 地：中国大陆

  • T78141LFHP-1c；化合物 LFHP-1cLFHP-1c

    LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral artery occlusion (tMCAO) in rats.LFHP-1c can be used to study cerebral ischemic stroke.

    价 格：￥电议型 号：T78141产 地：中国大陆

  • T78093Cisd2 agonist 1；化合物 Cisd2 agonist 1Cisd2 agonist 1

    Cisd2 agonist 1 (Compound 4q), with an EC50 of 34 nM, augments Cisd2 expression and ameliorates pathological alterations in fatty liver disease, demonstrating good metabolic stability. This compound is utilized in non-alcoholic fatty liver disease (NAFLD) research[1].

    价 格：￥电议型 号：T78093产 地：中国大陆

  • T77407Ensituximab；恩妥昔单抗NPC-1C|||NEO-102|||NEO-101；NPC-1C|||NEO-102|||NEO-101

    Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic cancer.

    价 格：￥电议型 号：T77407产 地：中国大陆

  • T77349CCR1/5/8 activator 1；化合物 CCR1/5/8 activator 1CCR1/5/8 activator 1

    CCR1/5/8 activator 1 is a cytoplasmic phospholipase A inhibitor with antifungal activity.

    价 格：￥电议型 号：T77349产 地：中国大陆

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