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  • T3664THZ1；化合物THZ1CDK7 inhibitor|||THZ1 2HCl；CDK7 inhibitor|||THZ1 2HCl

    THZ1 (CDK7 inhibitor) is a novel selective and potent covalent CDK7 inhibitor.

    价 格：￥电议型 号：T3664产 地：中国大陆

  • T36627Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)；Lysine-specific Demethylase Inhibitor (1C

    Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protei

    价 格：￥电议型 号：T36627产 地：中国大陆

  • T36496Conglobatin C1；Conglobatin C1Conglobatin C1；Conglobatin C1

    Conglobatin C1 is a bacterial metabolite that has been found inStreptomycesMST-91080 and has anticancer activity.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 1.05 μg/ml) but not NFF human fibroblasts (IC50= >100 μg/ml).

    价 格：￥电议型 号：T36496产 地：中国大陆

  • T36464Caylin-1；Caylin-1Caylin-1

    Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT116 cells with an IC50 value of approximately 7 μM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at

    价 格：￥电议型 号：T36464产 地：中国大陆

  • T36458CAY10701；CAY10701CAY10701；CAY10701

    CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells. CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body

    价 格：￥电议型 号：T36458产 地：中国大陆

  • T36191CAY10681CAY10681CAY10681|||CAY-10681

    Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 is a dual modulator of p53-MDM2 interaction and NF-κB signaling. It potently binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53. CAY10681 also inhibits phosphorylation of IκBα and dose-dependently reduces nuclear accumulation of p65. It blocks the proliferation of cancer cell lines (IC50s range from 33 to 37 μM). CAY10681 exhibits excellent oral bioavailability and

    价 格：￥电议型 号：T36191产 地：中国大陆

  • T36106Coumermycin A1；Coumermycin A1Coumermycin A1

    Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.

    价 格：￥电议型 号：T36106产 地：中国大陆

  • T3587NOD-IN-1；化合物NOD-IN-1Compound 4；Compound 4

    NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.

    价 格：￥电议型 号：T3587产 地：中国大陆

  • T35861COQ7-IN-1COQ7-IN-1COQ7-IN-1

    COQ7-IN-1 is a powerful inhibitor of human coenzyme Q (COQ7), effectively disrupting the synthesis of ubiquinone (UQ) in the body. Notably, COQ7-IN-1 does not disrupt the natural growth of human normal culture cells. This compound proves valuable for investigating the equilibrium between two pathways of UQ supplementation: de novo UQ synthesis and extracellular UQ uptake[1].

    价 格：￥电议型 号：T35861产 地：中国大陆

  • T35821CAY10721；CAY10721CAY10721

    CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.

    价 格：￥电议型 号：T35821产 地：中国大陆

  • T35812CAY10591；CAY10591CAY10591；CAY10591

    Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This com

    价 格：￥电议型 号：T35812产 地：中国大陆

  • T35594Cuspin-1Cuspin-1Cuspin 1|||Cuspin1

    The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Ra

    价 格：￥电议型 号：T35594产 地：中国大陆

  • T35092W 341C；化合物 T35092W-341C|||W341C；W-341C|||W341C

    W 341C is a biochemical.

    价 格：￥电议型 号：T35092产 地：中国大陆

  • T34801Temodox；化合物 T34801CP-22,341|||CP22341|||CP-22341|||CP 22341|||CP 22,341；CP-22,341|||CP22341|||CP-223

    Temodox, also known as CP 22341, is a bioactive chemical.

    价 格：￥电议型 号：T34801产 地：中国大陆

  • T3476JI-101；化合物JI101CGI-1842|||JI 101；CGI-1842|||JI 101

    JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4).

    价 格：￥电议型 号：T3476产 地：中国大陆

  • T34331Ristianol phosphate；化合物 T34331CP 48,867-9|||CP-48,867-9；CP 48,867-9|||CP-48,867-9

    Ristianol phosphate is a bio-active chemical.

    价 格：￥电议型 号：T34331产 地：中国大陆

  • T34231Quinterenol sulfate；化合物 T34231CP-10,303-8|||Quinprenaline sulfate|||CP 10,303-8；CP-10,303-8|||Quinpr

    Quinoline sulfate has a bronchiectasis effect on patients with asthma.

    价 格：￥电议型 号：T34231产 地：中国大陆

  • T3410Momordin Ic；地肤子皂苷IcMomordin 1c；地肤子皂苷Ic|||地肤子皂苷 Ic|||Momordin 1c

    Momordin Ic (Momordin 1c) might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. Also, Momordin Ic accelerates gastrointestinal transit partially by stimulating synthesis of 5-HT to act through 5-HT(2), which, in turn, increases synthesis of prostaglandins.

    价 格：￥电议型 号：T3410产 地：中国大陆

  • T33711Nolomirole；化合物 T33711CHF1025|||CHF-1025|||CHF 1025；CHF1025|||CHF-1025|||CHF 1025

    Nolomirole is a dopamine receptor agonist that reduces symptoms of congestive heart failure caused by monoclinine.

    价 格：￥电议型 号：T33711产 地：中国大陆

  • T33691Nitrosofolic acid；化合物 T33691CCRIS 466|||N-Nitrosofolic acid|||Glutamic acid, N-nitroso-N-pteroyl-, L

    Nitrosofolic acid is a folic acid derivaive.

    价 格：￥电议型 号：T33691产 地：中国大陆

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