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T3700SCH900776 (S-isomer);化合物SCH900776 S-isomerMK-8776 S-isomer|||SCH900776 S-isomer;MK-8776 S-isomer|||S
SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM).
价 格:¥电议型 号:T3700产 地:中国大陆
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T36819Ac-FLTD-CMK;化合物Ac-FLTD-CMKAc-FLTD-CMK
Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects on caspases-1, caspases-4 and caspases-11 with IC50s of 46.7 nM, 1.49 μM and 329 nM, respectively. Ac-FLTD-CMK showed potency against caspases-1, caspases-4 and caspases-11, but not against apoptosis-associated caspase-3.
价 格:¥电议型 号:T36819产 地:中国大陆
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T36778MK2-IN-1;MK2-IN-1 (MK2 Inhibitor)MK2-IN-1 (MK2 Inhibitor);MK2-IN-1 (MK2 Inhibitor)
MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.
价 格:¥电议型 号:T36778产 地:中国大陆
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T36347Ac-YVAD-CMK;化合物Ac-YVAD-CMKCaspase-1 Inhibitor II|||Ac-Tyr-Val-Ala-Asp-chloromethylketone|||Ac-Tyr-Va
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
价 格:¥电议型 号:T36347产 地:中国大陆
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T36338AAF-CMK (trifluoroacetate salt);AAF-CMK (trifluoroacetate salt)AAF-CMK (trifluoroacetate salt)
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 μM.
价 格:¥电议型 号:T36338产 地:中国大陆
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T36331Z-AEVD-FMK;Z-AEVD-FMKZ-AEVD-FMK|||Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone;Z-AEVD-FMK|||Z-Ala-Glu-Val-A
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]
价 格:¥电议型 号:T36331产 地:中国大陆
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T3632Doravirine;多拉维林MK-1439;多拉维林|||多拉韦林|||MK-1439
Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
价 格:¥电议型 号:T3632产 地:中国大陆
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T36203Menaquinone 9;Menaquinone 9MK-9|||Vitamin K2(45)|||Menaquinone 9;MK-9|||Vitamin K2(45)|||Menaquinone
Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain.
价 格:¥电议型 号:T36203产 地:中国大陆
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T36176AMK (hydrochloride);AMK (hydrochloride)AMK (hydrochloride)
AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7
价 格:¥电议型 号:T36176产 地:中国大陆
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T36091LEESGGGLVQPGGSMK acetate;LEESGGGLVQPGGSMK acetateLEESGGGLVQPGGSMK acetate
LEESGGGLVQPGGSMK acetate is a proteolysis peptide found in Infliximab, a chimeric monoclonal IgG1 antibody. It serves as a component of Infliximab and can be employed for the quantitative analysis of this antibody. Infliximab is specifically designed to bind to TNF-α[1].
价 格:¥电议型 号:T36091产 地:中国大陆
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T35782Swinholide A;猪苓内酯AMK-7684;MK-7684
Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells.
价 格:¥电议型 号:T35782产 地:中国大陆
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T34624Setileuton;化合物SetileutonMK0633|||MK 0633|||MK-0633;MK0633|||MK 0633|||MK-0633
Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
价 格:¥电议型 号:T34624产 地:中国大陆
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T3361Cambendazole;坎苯达唑Bonlam|||MK-905|||Novazole;坎苯达唑|||Bonlam|||MK-905|||Novazole
Cambendazole (Novazole) is one of the most effective agents for the therapy of human strongyloidiasis. Cambendazole is a nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.
价 格:¥电议型 号:T3361产 地:中国大陆
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T3353Niraparib hydrochloride;尼拉帕利盐酸盐MK-4827 hydrochloride|||MK-4827 (hydrochloride);尼拉帕利盐酸盐|||MK-4827 hyd
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single-strand DNA breaks by the base-excision repair (BER) pathway.
价 格:¥电议型 号:T3353产 地:中国大陆
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T33447MK-B 251;化合物 T33447MK B 251|||MK B 251;MKB-251|||MK-B251|||MKB 251|||MK-B-251|||MKB-251|||MKB251;MK
MK-B 251 is a potential bioactive agent. No further details yet.
价 格:¥电议型 号:T33447产 地:中国大陆
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T33446MK-9470;化合物 T33446MK 9470|||MK9470;MK 9470|||MK9470
MK-9470 is a selective, high-affinity reverse agonist and is also a fluorine 18 labeled positron emission tomography (PET) radiotracer [(18) F]. The MK-9470 has been used to image cannabinoid receptor type 1 in healthy and ill human brains.
价 格:¥电议型 号:T33446产 地:中国大陆
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T33445MK-940;化合物 T33445MK940;MK940
MK-940 is an effective central nervous system drug and antidepressant.
价 格:¥电议型 号:T33445产 地:中国大陆
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T33444MK-912;化合物 T33444MK912|||MK 912;MK912|||MK 912
MK-912 is a potent novel selective alpha2-adrenergic receptor antagonist with oral activity to study the effect of short-term selective alpha2-blockers on fasting glucose (FPG) and islet function in non-insulin-dependent patients with diabetes mellitus (NIDDM).
价 格:¥电议型 号:T33444产 地:中国大陆
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T33443MK-8970;化合物 T33443MK-8970
MK-8970 is an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.
价 格:¥电议型 号:T33443产 地:中国大陆
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T33442MK-8718;化合物 T33442MK 8718;MK 8718
MK-8718 is an HIV protease inhibitor with a selective orally bioavailable inhibitor with good pharmacokinetic characteristics.
价 格:¥电议型 号:T33442产 地:中国大陆