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T6274RO4929097RO4929097,RG-4733,
RO4929097, a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
价 格:¥电议型 号:T6274产 地:美洲
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T6410BexaroteneBexarotene,LGD1069,Targretin
Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
价 格:¥电议型 号:T6410产 地:美洲
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T6570L-NAME hydrochlorideL-NAME hydrochloride,NG-Nitroarginine methyl ester hydrochloride,L-NAME HCl
L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM,15 nM, and 39 nM, for iNOS (mouse) ,nNOS (bovine) , and eNOS (human), respectively.
价 格:¥电议型 号:T6570产 地:美洲
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T8809[Des-Arg9]-Bradykinin TFA;化合物[Des-Arg9]-Bradykinin TFA[Des-Arg9]-Bradykinin TFA
[Des-Arg9]-Bradykinin is an agonist of Bradykinin (B1) receptor that displays selectivity for B1 over B2 receptors.
价 格:¥电议型 号:T8809产 地:中国大陆
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T8726Cyclo(RGDyK)化合物 T8726Cyclo(RGDyK)
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
价 格:¥电议型 号:T8726产 地:中国大陆
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T8683Mipsagargin;化合物MipsagarginG-202;G-202
Mipsagargin (G-202) is a new antibiotic that inhibits DNA biosynthesis.
价 格:¥电议型 号:T8683产 地:中国大陆
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T8556Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base);化合物Z-Gly-Gly-Arg-AMC TFAZ-Gly-Gly-Arg-AMC TFA;Z-Gly-Gly
Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) is a thrombin-specific fluorogenic substrate for testing thrombin generation in PRP and platelet-poor plasma (PPP).
价 格:¥电议型 号:T8556产 地:中国大陆
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T83857Soluble Epoxide Hydrolase PROTAC 1a;化合物 Soluble Epoxide Hydrolase PROTAC 1asEH Proteolysis-targeting
Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its hydrolase activity (IC50 = 0.8 nM) significantly more than its phosphatase activity (IC50 = >10,000 nM). This compound preferentially targets cytosolic sEH for lysosomal rather than proteasomal degradation. Furthermore, it mitigates thapsigargin-induced upregulation of phosphoryla
价 格:¥电议型 号:T83857产 地:中国大陆
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T8382Cariprazine hydrochloride;盐酸卡利拉嗪Cariprazine HCl|||RGH188 hydrochloride;Cariprazine HCl|||盐酸卡利拉嗪|||RG
Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
价 格:¥电议型 号:T8382产 地:中国大陆
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T837996-alkyne NAD+ sodium;化合物 6-alkyne NAD+ sodiumβ-Nicotinamide-N6-propargyladenine dinucleotide|||6-Par
6-alkyne NAD+, a clickable variant of the signaling molecule and enzyme cofactor NAD+, facilitates the fluorescent tagging for the detection of poly(ADP-ribose) polymerase (PARP) protein substrates.
价 格:¥电议型 号:T83799产 地:中国大陆
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T83769TC 14012 hydrochloride;化合物 TC 14012 hydrochlorideH-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit
TC 14012, a peptidomimetic compound, acts as both an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 2.9 nM) and as an agonist for CXCR7, effectively recruiting β-arrestin in HEK293T cells that express CXCR7 (EC50 = 350 nM). Moreover, it demonstrates significant antiviral activity by reducing the cytopathic effects of HIV in MT-4 cells with an EC50 value of 0.4 nM and inhibiting HIV entry in vitro through a CXCR4-dependent pathway (IC50 = 19.3 nM). Additionally, TC 14012 supp
价 格:¥电议型 号:T83769产 地:中国大陆
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T83757RG33 TFA;化合物 RG33 TFARG33 TFA
RG33, a synthetic 33-amino acid peptide, matches the sequence of amino acids 209-219 and 220-241 found in the C-terminal domain class Y helices of apolipoprotein A1 (ApoA1). This compound has the ability to solubilize multilamellar vesicles (MLVs) containing 1,2-dimyristoyl-sn-glycero-3-PC (DMPC), resulting in the formation of recombinant HDL. When bound to lipids, RG33 facilitates cholesterol efflux in J774 macrophages and has been shown to reduce blood glucose levels in insulin-resistant mice
价 格:¥电议型 号:T83757产 地:中国大陆
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T83748RW4 TFA;化合物 RW4 TFA(RW)4-NH2|||Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2;(RW)4-NH2|||Arg-Trp-Arg-Trp-Arg-T
RW4, an antimicrobial peptide, exhibits activity against E. coli and S. aureus, with IC50 values of 9.6 and 5.1 ?M, respectively. Additionally, it induces hemolysis of isolated ovine erythrocytes.
价 格:¥电议型 号:T83748产 地:中国大陆
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T83747RW3 TFA;化合物 RW3 TFA(RW)3-NH2|||Arg-Trp-Arg-Trp-Arg-Trp-NH2;(RW)3-NH2|||Arg-Trp-Arg-Trp-Arg-Trp-NH2
RW3, an antimicrobial peptide, exhibits activity against E. coli and S. aureus with IC50 values of 16 ?M and 8 ?M, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes.
价 格:¥电议型 号:T83747产 地:中国大陆
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T83746RW2 TFA;化合物 RW2 TFA(RW)2-NH2|||Arg-Trp-Arg-Trp-NH2;(RW)2-NH2|||Arg-Trp-Arg-Trp-NH2
RW2, an antimicrobial peptide, demonstrates activity against E. coli and S. aureus, with IC50 values of 730 ?M and 210 ?M, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes.
价 格:¥电议型 号:T83746产 地:中国大陆
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T83745RYTVELA TFA;化合物 RYTVELA TFAH-Arg-Tyr-Thr-Val-Glu-Leu-Ala-OH;H-Arg-Tyr-Thr-Val-Glu-Leu-Ala-OH
RYTVELA is a derivative of the peptide antagonist rytvela, targeting interleukin-1 receptor 1 (IL-1R1), and is comprised entirely of L-amino acids.
价 格:¥电议型 号:T83745产 地:中国大陆
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T83744Tiger17 TFA;化合物 Tiger17 TFAH-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2;H-Trp-Cys-Lys-Pro-Lys-P
Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2—antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions—enhances HaCaT keratinocytes and human skin fibroblasts proliferation at 5 to 20 ?g/ml concentrations, and promotes HaCaT cell migration at 20 ?g/ml. Additionally, Tiger17 augments RAW 264.7 macrophages´ recruitment and secretion of TGF-β1 and IL-6. When topically applied at 20 ?g/ml, it accelerates wound closure and re-epithelialization i
价 格:¥电议型 号:T83744产 地:中国大陆
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T83741S7 TFA;化合物 S7 TFALeu-Ser-Leu-Iso-Thr-Arg-Leu-OH;Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH
S7, a peptide antagonist of the IL-6 receptor, concentration-dependently inhibits IL-6 binding to its receptor. At 50 ?M, S7 suppresses IL-6-triggered elevations in VEGF levels within C-33 A cervical cancer cells and RPMI-8226 B cell lymphocytes. It significantly reduces tumor volume in a C-33 A cervical cancer mouse xenograft model with IL-6 overexpression, following a dosage regimen of 50 mg/kg bi-daily. Moreover, when linked to cysteine on lipid nanoparticles (LNPs) encapsulating doxorubicin,
价 格:¥电议型 号:T83741产 地:中国大陆
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T83737LRRKtide TFA;化合物 LRRKtide TFAMoesin (550-564)|||Membrane-organizing Extension Spike Protein (550-564
LRRKtide, a peptide substrate for leucine-rich repeat kinase 2 (LRRK2)—an enzyme often mutated in Parkinson´s disease patients—corresponds to amino acids 550-564 of the membrane-organizing extension spike protein (moesin). It serves to identify inhibitors of LRRK2.
价 格:¥电议型 号:T83737产 地:中国大陆
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T83724TPP-1 hydrochloride;化合物 TPP-1 hydrochlorideTargeting PD-L1 Peptide;Targeting PD-L1 Peptide
TPP-1, a peptide inhibitor, targets the interaction between programmed cell death protein 1 (PD-1) and its ligand (PD-L1), binding specifically to PD-L1 with a dissociation constant (Kd) of 94.67 nM. At a concentration of 20 ?M, TPP-1 effectively counteracts the PD-L1-induced suppression of IFN-γ production in anti-CD3-stimulated isolated human CD4+ T cells. Furthermore, TPP-1 demonstrates significant efficacy in reducing tumor volume in a mouse xenograft model of HL-60 leukemia. This model invo
价 格:¥电议型 号:T83724产 地:中国大陆