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T11101DS08210767DS-08210767,DS08210767
DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
价 格:¥电议型 号:T11101产 地:中国大陆
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T4118SB 271046 hydrochlorideoral,test,Serotonin Receptor,SB271046,5-HT Receptor,Inhibitor,inhibit,5-hydro
SB 271046 hydrochloride is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT1B, 5-HT1F, α1B, 5-HT2C, 5-HT2A, D2, 5-HT2B, 5-HT7, 5-HT4 and 5-HT1E respectively) and is > 200-fold selective over 55 other receptors, enzymes and ion channels. It increases extracellular aspartate and glutamate in the frontal cortex and exhibits anticonvulsant activity (EC50:
价 格:¥电议型 号:T4118产 地:中国大陆
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T41194FFN 102 mesylateFFN 102 mesylate
FFN 102 mesylate is a pH responsive fluorescent false neurotransmitter (FFN), a selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake. Excitation maxima are 340 nm at pH 5 and 370 nm at pH 7.5. Emission maximum is 435 nm at both pH 5 and 7.5.FFN 102 mesylate is a Ph-responsive fluorescent pseudoneurotransmitter (FFN) that acts as a substrate for selective dopam
价 格:¥电议型 号:T41194产 地:中国大陆
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T11087DOV-216,303 Free Baseinhibit,SLC6A4,Serotonin Transporter,DOV 216,303 Free Base,5-HTT,DAT,DOV-216,30
DOV-216,303 Free Base is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.
价 格:¥电议型 号:T11087产 地:中国大陆
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TQ0194trans-Vaccenic acidEndogenous Metabolite,Inhibitor,trans-Vaccenic acid,inhibit,trans Vaccenic acid,t
trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated linoleic acid at the tissue level.
价 格:¥电议型 号:TQ0194产 地:中国大陆
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T22325EPZ020411 hydrochlorideEPZ-020411 hydrochloride,EPZ020411 hydrochloride
EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.
价 格:¥电议型 号:T22325产 地:中国大陆
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T9696β-catenin-IN-2HCT116,inhibit,cancer,β-catenin,cell,Beta catenin,HT-29,Tcf/4,Colorectal,Inhibitor,β c
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
价 格:¥电议型 号:T9696产 地:中国大陆
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T9108BI-0115inhibit,BI-0115,LOX-1,atherosclerosis,BI0115,BI 0115,oxLDL binding,Inhibitor
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
价 格:¥电议型 号:T9108产 地:中国大陆
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T7512BMS-191011Potassium Channel,rodent models of stroke,Panc-1,neuroprotective activity,inhibit,IGR39,BM
BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models
价 格:¥电议型 号:T7512产 地:中国大陆
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TP1185LCys-TAT(47-57) acetate(583836-55-9 Free base)CysTAT(4757) acetate(583836559 Free base),Cys TAT(47 57
Cys-TAT(47-57) acetate is derived from the HIV-1 transactivating protein. Cys-TAT(47-57) acetate is an arginine rich peptide that can penetrate cells.
价 格:¥电议型 号:TP1185L产 地:中国大陆
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TQ0110ROCK-IN-2inhibit,Rho-kinase,Rho-associated protein kinase,Azaindole-1,ROCKIN2,Rho-associated kinase,
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
价 格:¥电议型 号:TQ0110产 地:中国大陆
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T8993LBGC-20-1531 hydrochloride(1186532-61-5 free base)BGC201531 hydrochloride(1186532615 free base),BGC 2
BGC201531 hydrochloride is a EP4 antagonist for the treatment of acute migraine.
价 格:¥电议型 号:T8993L产 地:中国大陆
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T27471GSK299115AGSK299115A
GSK299115A is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.
价 格:¥电议型 号:T27471产 地:中国大陆
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T11693LIT1t dihydrochlorideIT1t dihydrochloride,IT-1t dihydrochloride
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
价 格:¥电议型 号:T11693L产 地:中国大陆
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TN31105-Geranoxy-7-methoxycoumarinApoptosis,5 Geranoxy 7 methoxycoumarin,Bacterial,Fungal,antifungal,inhib
5-Geranoxy-7-methoxycoumarin shows antifungal activity.
价 格:¥电议型 号:TN3110产 地:中国大陆
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TP1107LMas7 acetate(145854-59-7 free base)Mas7 acetate(145854 59 7 free base),Mas-7 acetate(145854-59-7 fre
Mas7 acetate, a structural analogue of mastoparan is a known activator of heterotrimeric Gi-proteins and its downstream effectors.
价 格:¥电议型 号:TP1107L产 地:中国大陆
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TQ0223LusutrombopagLusutrombopag,inhibit,Inhibitor,S888711,S 888711,Thrombopoietin Receptor
Lusutrombopag is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.
价 格:¥电议型 号:TQ0223产 地:中国大陆
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T7315BAY1125976inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)
价 格:¥电议型 号:T7315产 地:中国大陆
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T6458CYC-116CYC116,inhibit,Inhibitor,CYC-116,CYC 116,Aurora Kinase
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.
价 格:¥电议型 号:T6458产 地:中国大陆
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T11828LDC7559Inhibitor,Pyroptosis,LDC7559,inhibit,LDC 7559,LDC-7559
LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.
价 格:¥电议型 号:T11828产 地:中国大陆