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  • T38034MAO-IN-M30 dihydrochloride；化合物MAO-IN-M30二盐酸盐M 30 dihydrochloride；M 30 dihydrochloride

    MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson´s disease model.

    价 格：￥电议型 号：T38034产 地：中国大陆

  • T37817Terazosin dimer impurity dihydrochloride；双盐酸特拉唑嗪杂质Terazosin dimer impurity dihydrochloride

    Terazosin dimer impurity dihydrochloride, a dimeric form of Terazosin, is a chemical impurity found in Terazosin. Terazosin itself is a derivative of quinazoline and acts as a competitive and orally active α1-adrenoceptor antagonist[1].

    价 格：￥电议型 号：T37817产 地：中国大陆

  • T37114SB 242084 dihydrochloride；SB-242084 (hydrochloride)SB 242084 dihydrochloride

    SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.

    价 格：￥电议型 号：T37114产 地：中国大陆

  • T37112YNT-185 dihydrochloride；YNT 185YNT-185 dihydrochloride

    Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

    价 格：￥电议型 号：T37112产 地：中国大陆

  • T37034H-Gly-Arg-pNA dihydrochloride；H-Gly-Arg-pNA二盐酸盐H-Gly-Arg-Pna 2HCl；H-Gly-Arg-Pna 2HCl

    H-Gly-Arg-pNA dihydrochloride (H-Gly-Arg-Pna 2HCl) belongs to the class of peptides that bind to 1,2 thrombin and can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.

    价 格：￥电议型 号：T37034产 地：中国大陆

  • T36994MRT 67307 dihydrochloride；化合物MRT 67307盐酸盐MRT 67307 dihydrochloride

    MRT 67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.

    价 格：￥电议型 号：T36994产 地：中国大陆

  • T36981GSK 591 dihydrochlorideGSK 591 dihydrochlorideGSK 591 dihydrochloride

    Potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro. To request the negative control for GSK 591, please fill out the SGC 2096 request form on the SGC website.

    价 格：￥电议型 号：T36981产 地：中国大陆

  • T36733HLI373 dihydrochloride；HLI373 dihydrochlorideHLI373 dihydrochloride

    HLI373 dihydrochloride is a potent Hdm2 inhibitor, efficiently restraining the ubiquitin ligase activity of Hdm2 and effectively prompting apoptosis in DNA-damaging agent-sensitive tumor cells[1]. Additionally, HLI373 dihydrochloride exhibits antimalarial activity[2].

    价 格：￥电议型 号：T36733产 地：中国大陆

  • T36717RWJ-56110 dihydrochloride；RWJ-56110 dihydrochlorideRWJ-56110 dihydrochloride

    RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap

    价 格：￥电议型 号：T36717产 地：中国大陆

  • T36704CCT241533 dihydrochloride；CCT 241533 dihydrochlorideCCT 241533 dihydrochloride；CCT 241533 dihydrochl

    Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

    价 格：￥电议型 号：T36704产 地：中国大陆

  • T36673CC 401 dihydrochloride；CC 401 dihydrochlorideCC 401 dihydrochloride

    High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication.

    价 格：￥电议型 号：T36673产 地：中国大陆

  • T36349CGP 74514 dihydrochloride；CGP 74514 dihydrochlorideCGP 74514 dihydrochloride

    Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.

    价 格：￥电议型 号：T36349产 地：中国大陆

  • T36284(S,R,S)-AHPC-C8-NH2 dihydrochloride；VH 032 amide-alkylC8-amineVH 032 amide-alkylC8-amine；VH 032 amid

    Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 11 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

    价 格：￥电议型 号：T36284产 地：中国大陆

  • T36270(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride；VH 032 phenol-alkylC6-amineVH 032 phenol-alkylC6-a

    Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 phenol - linker 2 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

    价 格：￥电议型 号：T36270产 地：中国大陆

  • T36269(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride；VH 032 phenol-alkylC4-amineVH 032 phenol-alkylC4-amine；VH

    Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 phenol - linker 1 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

    价 格：￥电议型 号：T36269产 地：中国大陆

  • T36264(S,R,S)-AHPC-PEG1-NH2 dihydrochloride；VH 032 amide-PEG1-amineVH 032 amide-PEG1-amine；VH 032 amide-PE

    Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 9 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

    价 格：￥电议型 号：T36264产 地：中国大陆

  • T36201AZD5582 dihydrochloride；AZD 5582 dihydrochlorideAZD 5582 dihydrochloride；AZD 5582 dihydrochloride

    Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

    价 格：￥电议型 号：T36201产 地：中国大陆

  • T36109L Moses dihydrochloride；L Moses dihydrochlorideL Moses dihydrochloride

    High affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM). Exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). Exhibits >4500-fold selectivity for PCAF over BRD4. Also exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).

    价 格：￥电议型 号：T36109产 地：中国大陆

  • T36016PF 06260933 dihydrochloride；PF 06260933 dihydrochloridePF 06260933 dihydrochloride

    MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

    价 格：￥电议型 号：T36016产 地：中国大陆

  • T3597Cutamesine dihydrochloride；库他美新二盐酸盐AGY94806 dihydrochloride|||SA4503 (dihydrochloride)|||SA4503 dihy

    Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. In a rat model of experimental stroke, it enhances brain plasticity and sensorimotor function.

    价 格：￥电议型 号：T3597产 地：中国大陆

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