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T71707LRomergoline 2HCl;罗麦角林Romergoline 2HCl(107052-56-2 Free base)|||FCE 23884 2HCl;Romergoline 2HCl(10705
Romergoline 2HCl is a D1 agonist and D2 antagonist used in the study of Parkinson´s disease.
价 格:¥电议型 号:T71707L产 地:中国大陆
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T71631Eucatropine;化合物 Eucatropine Free BaseEucatropine
Eucatropine, an anticholinergic agent, acts as a potent inhibitor of the muscarinic acetylcholine receptor (mAChR) with an IC 50 value of 0.583 μM.
价 格:¥电议型 号:T71631产 地:中国大陆
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T71607EXP-561 Free Base;化合物 EXP-561 Free BaseEXP-561 Free Base
EXP-561 Free Base is an investigational drug that acts as an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine.
价 格:¥电议型 号:T71607产 地:中国大陆
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T71593AVN-101 free base;化合物 AVN-101 free baseAVN-101 free base
AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.
价 格:¥电议型 号:T71593产 地:中国大陆
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T71582Niguldipine Free Base;化合物 Niguldipine Free BaseNiguldipine Free Base
Niguldipine Free Base is a calcium channel blocker and a?-adrenergic receptor antagonist and a clinical modulator of multidrug resistance.
价 格:¥电议型 号:T71582产 地:中国大陆
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T71534LCIA-1 (Free base);化合物CIA-1CIA-1(Free base);CIA-1(Free base)
CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhibits tumor growth in a mouse model of prostate cancer xenografts.
价 格:¥电议型 号:T71534L产 地:中国大陆
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T71534CIA-1 hcl(452087-38-6 Free base);化合物CIA-1 hcl(452087-38-6 Free base)CIA-1 hcl(452087-38-6 Free base)
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of prostate cancer cell lines in vitro and inhibits COUP-TFII activity to regulate its target genes.CIA-1 in vivo exhibits tumor growth inhibitory effects in a mouse model of prostate cancer xenografts. inhibitory effect on tumor growth in a xenograft mouse model of prostate cancer in vivo.
价 格:¥电议型 号:T71534产 地:中国大陆
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T71532Fondaparinux free base;化合物 Fondaparinux free baseFondaparinux free base
Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs.
价 格:¥电议型 号:T71532产 地:中国大陆
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T71491Enadoline (Free Base);化合物 Enadoline (Free Base)Enadoline (Free Base)
Enadoline (Free Base) is a kappa-opioid receptor agonist; PD 129290 (CAM 570; CI 977) is the S,S(-)-enantiomer; PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer. In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A. It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. There was mention of its potential in treating com
价 格:¥电议型 号:T71491产 地:中国大陆
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T71481Migalastat;化合物 MigalastatGR181413A free base;GR181413A free base
Migalastat (GR181413A free base) is an orally administered, competitive inhibitor of α-galactosidase A (α-Gal A), demonstrating an IC50 value of 0.04 μM against human α-Gal A.
价 格:¥电议型 号:T71481产 地:中国大陆
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T71451Zaldaride (free base);化合物 Zaldaride (free base)Zaldaride (free base)
Zaldaride (free base) is a calmodulin antagonist.
价 格:¥电议型 号:T71451产 地:中国大陆
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T71449Capreomycin free base;化合物 Capreomycin free baseCapreomycin free base
Capreomycin is a polypeptide antibiotic originally isolated from S. capreolus. It is active against M. tuberculosis (MIC = 10 ?g/ml). Capreomycin binds to both the 30S and 50S ribosomal subunits, inhibiting protein synthesis.
价 格:¥电议型 号:T71449产 地:中国大陆
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T71445Bleomycin Free Base;化合物 Bleomycin Free BaseBleomycin Free Base
Bleomycin Free Base is a complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
价 格:¥电议型 号:T71445产 地:中国大陆
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T71424VT-102 free base;化合物 VT-102 free baseVT-102 free base
VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
价 格:¥电议型 号:T71424产 地:中国大陆
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T71365Etoloxamine Free Base;化合物 Etoloxamine Free BaseEtoloxamine Free Base
Etoloxamine Free Base is a histamine 1 receptor antagonist.
价 格:¥电议型 号:T71365产 地:中国大陆
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T71362GCC-4401C free base;化合物 GCC-4401C free baseGCC-4401C free base
GCC-4401C free base is a factor Xa inhibitor similar to rivaroxaban that is currently under development for venous thromboembolic disease (VTE).
价 格:¥电议型 号:T71362产 地:中国大陆
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T71268Esoxybutynin Free Base;化合物 Esoxybutynin Free BaseEsoxybutynin Free Base
Esoxybutynin Free Base is (S)-enantiomer of oxybutynin. Esoxybutynin Free Base exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza´s Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence.
价 格:¥电议型 号:T71268产 地:中国大陆
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T71176Atiprimod (free base);化合物 Atiprimod (free base)Atiprimod (free base)
Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, ind
价 格:¥电议型 号:T71176产 地:中国大陆
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T71122Carsatrin (free base);化合物 Carsatrin (free base)Carsatrin (free base)
Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin
价 格:¥电议型 号:T71122产 地:中国大陆
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T71119Netarsudil free base;化合物 Netarsudil free baseNetarsudil free base
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and?/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1?nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16?nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudi
价 格:¥电议型 号:T71119产 地:中国大陆