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T71033ZD7114 free base；化合物 ZD7114 free baseZD7114 free base
ZD7114, also known as ICI-D7114, is a selective adrenoceptor agonist of brown fat and thermogenesis. ICI D7114 stimulates thermogenesis at doses that have little effect on beta 1 or beta 2 adrenoceptors. Treatment with ICI D7114 activates BAT and thermogenesis even in species and situations where the intrinsic capacity is low. ICI D7114 has beneficial effects in animal models of obesity and disturbed glucose and lipid homeostasis.
价 格：￥电议型 号：T71033产 地：中国大陆
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T71023MI-888 free base；化合物 MI-888 free baseMI-888 free base
MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.
价 格：￥电议型 号：T71023产 地：中国大陆
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T71012Nemazoline Free Base；奈马唑啉Nemazoline Free Base
Nemazoline Free Base acts as an α1-adrenergic agonist and an α2-adrenergic antagonist, and may be used in the treatment of trace amine-associated receptor-related disorders.
价 格：￥电议型 号：T71012产 地：中国大陆
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T70979Sunepitron Free Base；化合物 Sunepitron Free BaseSunepitron Free Base
Sunepitron Free Base is a combined 5-HT1A receptor agonist and α?-adrenergic receptor antagonist. It was previously under development by Pfizer for the treatment of depression and anxiety. It made it to phase III clinical trials before being discontinued.
价 格：￥电议型 号：T70979产 地：中国大陆
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T70908EST64454 free base；化合物 EST64454 free baseEST64454 free base
EST64454 is a σ1 receptor (σ1R) antagonist clinical candidate for the treatment of pain. EST64454 shows an outstanding aqueous solubility, which together with its high permeability in Caco-2 cells will allow its classification as a BCS class I compound. It also shows high metabolic stability.
价 格：￥电议型 号：T70908产 地：中国大陆
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T70840Osemozotan Free Base；化合物 Osemozotan Free BaseOsemozotan Free Base
Osemozotan Free Base is a 5-HT(1A) receptor agonist.
价 格：￥电议型 号：T70840产 地：中国大陆
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T70809BD 1008 Free Base；化合物 BD 1008 Free BaseBD 1008 Free Base
BD 1008 Free Base is a selective sigma receptor antagonist, with a reported binding affinity of K? = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor.
价 格：￥电议型 号：T70809产 地：中国大陆
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T70800Elenbecestat free base；化合物 Elenbecestat free baseElenbecestat free base
Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD.
价 格：￥电议型 号：T70800产 地：中国大陆
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T70793Parogrelil Free Base；帕格雷利NM-702 Free Base；NM-702 Free Base
Parogrelil Free Base (NM-702 Free Base) is a selective phosphodiesterase 3 inhibitor with bronchodilatory and anti-inflammatory effects, inhibits leukotriene (LT)D(4) and histamine-induced constriction of isolated guinea pig tracheal strips, and can be used in the study of bronchial asthma.
价 格：￥电议型 号：T70793产 地：中国大陆
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T70776AS-1669058 free base；化合物 AS-1669058 free baseAS-1669058 free base
AS-1669058 free base is a G-protein-coupled receptor 119 (GPR119) agonist used to as new drug to treat type 2 diabetes.
价 格：￥电议型 号：T70776产 地：中国大陆
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T70770Cyclazosin Free Base；化合物 Cyclazosin Free BaseCyclazosin Free Base
Cyclazosin Free Base is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of furoic acid with the secondary amino group of 6,7-dimethoxy-2-[(4aR,8aS)-octahydroquinoxalin-1-yl]quinazolin-4-amine. It has a role as an adenosine A2A receptor antagonist. It is a member of quinazolines, a member of furans, an aromatic ether, a quinoxaline derivative, an aromatic amide and a monocarboxylic acid amide.
价 格：￥电议型 号：T70770产 地：中国大陆
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T70752Neomycin (free base)；化合物 Neomycin (free base)Neomycin (free base)
Neomycin (free base) is an antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.
价 格：￥电议型 号：T70752产 地：中国大陆
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T70751PF-719 free base；化合物 PF-719 free basePF-719 free base
PF-719 is a potent, selective Pyk2 inhibitor with IC50 of 17 nM.
价 格：￥电议型 号：T70751产 地：中国大陆
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T70555Tecalcet Free Base；化合物 Tecalcet Free BaseTecalcet Free Base
Tecalcet Free Base is an oral calcium receptor agonist
价 格：￥电议型 号：T70555产 地：中国大陆
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T70513NB-506 Free Base；化合物 NB-506 Free BaseNB-506 Free Base
NB-506 Free Base is an indolocarbazole antitumor agent; a DNA topoisomerase I inhibitor.
价 格：￥电议型 号：T70513产 地：中国大陆
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T70487Tofenacin (free base)；化合物 Tofenacin (free base)Tofenacin (free base)
Tofenacin (free base) is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson´s disease patients.
价 格：￥电议型 号：T70487产 地：中国大陆
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T70482DMP-728 free base；化合物 DMP-728 free baseDMP-728 free base
DMP-728 free base is a highly potent and selective GPIIbDIIa antagonist
价 格：￥电议型 号：T70482产 地：中国大陆
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T70473Parapenzolate Free Base；化合物 Parapenzolate Free BaseParapenzolate Free Base
Parapenzolate Free Base is a safe and effective anticholinergic drug possessing antisecretory and antimotility properties and prolonged duration of action. Clinical investigation has shown that after an oral dose of the drug there was inhibition of both basal and histamine-stimulated acid outputs.
价 格：￥电议型 号：T70473产 地：中国大陆
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T70456Nolpitantium Free Base；化合物 Nolpitantium Free BaseNolpitantium Free Base
Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no eff
价 格：￥电议型 号：T70456产 地：中国大陆
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T70412PNU-145156E free base；化合物 PNU-145156E free basePNU-145156E free base
PNU-145156E free base is an angiogenesis inhibitor.
价 格：￥电议型 号：T70412产 地：中国大陆
