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T72517ERK-IN-2 free base;化合物 ERK-IN-2 free baseERK-IN-2 free base
ERK-IN-2 free base, an inhibitor of ERK2, demonstrates potent efficacy with an IC50 value of 1.8 nM. However, doses exceeding 10 μM may result in off-target toxicity and/or activity.
价 格:¥电议型 号:T72517产 地:中国大陆
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T72513SC 51089 free base;化合物 SC 51089 free baseSC 51089 free base
SC 51089 free base is a selective antagonist of the prostaglandin E2 EP1 receptor, demonstrating neuroprotective activity. It exhibits binding affinities (Kis) of 1.3 μM for EP1, 11.2 μM for TP, 17.5 μM for EP3, and 61.1 μM for FP receptors, respectively.
价 格:¥电议型 号:T72513产 地:中国大陆
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T72091ADRA1D receptor antagonist 1 free base;化合物 ADRA1D receptor antagonist 1 free baseADRA1D receptor ant
ADRA1D receptor antagonist 1 (free base) antagonist ( K i =1.6 nM). ADRA1D receptor antagonist 1 (free base) dose-dependently inhibits bladder contraction with an IC 30 value of 15 nM. ADRA1D receptor antagonist 1 (free base) can be used in studies of overactive bladder disorders such as urinary urgency, frequency and incontinence.
价 格:¥电议型 号:T72091产 地:中国大陆
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T72058LCDD-1102 HCl;CDD-1102盐酸盐CDD-1102 HCl(2757619-84-2 Free base);CDD-1102 HCl(2757619-84-2 Free base)
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.
价 格:¥电议型 号:T72058L产 地:中国大陆
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T72038YM-58790;化合物YM-58790YM-58790 free base;YM-58790 free base
YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder contraction in rats by inhibiting bladder pressurization. YM-58790 free base inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization.
价 格:¥电议型 号:T72038产 地:中国大陆
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T71945Eleclazine free base;化合物 Eleclazine free baseEleclazine free base
Eleclazine, also known as GS-6615, is a selective late sodium current inhibitor. Eleclazine is potentially useful for treatment of coronary vasodilators, antiarrhythmics and vasodilators. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the T-wave in the heart’s electrical cycle) in patients with long QT-3 (LQT3) syndrome. LQT3 is a genetic disorder that prolongs the heart’s QTc interval and can cause life-threatening cardiac arrhyth
价 格:¥电议型 号:T71945产 地:中国大陆
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T71904Chlormadinone (free base);化合物 Chlormadinone (free base)Chlormadinone (free base)
Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.
价 格:¥电议型 号:T71904产 地:中国大陆
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T71772Bicifadine free base;化合物 Bicifadine free baseCL-220075|||Bicifadine free base|||CL220075|||Bicifadin
Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad
价 格:¥电议型 号:T71772产 地:中国大陆
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T7173L[Leu5]-Enkephalin acetate(58822-25-6 free base);亮氨酸脑啡肽Leucine enkephalin|||Leu-enkephalin|||Leucyl-e
[Leu5]-Enkephalin acetate(58822-25-6 free base) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
价 格:¥电议型 号:T7173L产 地:中国大陆
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T71728NW-1772 free base;化合物 NW-1772 free baseNW-1772 free base
NW-1772 free base is a monoamine oxidase B inhibitor.
价 格:¥电议型 号:T71728产 地:中国大陆
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T71709MDL-72527 free base;化合物 MDL-72527 free baseMDL-72527 free base
MDL-72527 free base is a polyamine oxidase inactivator.
价 格:¥电议型 号:T71709产 地:中国大陆
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T71707LRomergoline 2HCl;罗麦角林Romergoline 2HCl(107052-56-2 Free base)|||FCE 23884 2HCl;Romergoline 2HCl(10705
Romergoline 2HCl is a D1 agonist and D2 antagonist used in the study of Parkinson´s disease.
价 格:¥电议型 号:T71707L产 地:中国大陆
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T71631Eucatropine;化合物 Eucatropine Free BaseEucatropine
Eucatropine, an anticholinergic agent, acts as a potent inhibitor of the muscarinic acetylcholine receptor (mAChR) with an IC 50 value of 0.583 μM.
价 格:¥电议型 号:T71631产 地:中国大陆
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T71607EXP-561 Free Base;化合物 EXP-561 Free BaseEXP-561 Free Base
EXP-561 Free Base is an investigational drug that acts as an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine.
价 格:¥电议型 号:T71607产 地:中国大陆
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T71593AVN-101 free base;化合物 AVN-101 free baseAVN-101 free base
AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.
价 格:¥电议型 号:T71593产 地:中国大陆
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T71582Niguldipine Free Base;化合物 Niguldipine Free BaseNiguldipine Free Base
Niguldipine Free Base is a calcium channel blocker and a?-adrenergic receptor antagonist and a clinical modulator of multidrug resistance.
价 格:¥电议型 号:T71582产 地:中国大陆
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T71534LCIA-1 (Free base);化合物CIA-1CIA-1(Free base);CIA-1(Free base)
CIA-1 (Free base) is a nuclear receptor COUP-TFII inhibitor with IC50 values ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines. CIA-1 (Free base) inhibits tumor growth in a mouse model of prostate cancer xenografts.
价 格:¥电议型 号:T71534L产 地:中国大陆
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T71534CIA-1 hcl(452087-38-6 Free base);化合物CIA-1 hcl(452087-38-6 Free base)CIA-1 hcl(452087-38-6 Free base)
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of prostate cancer cell lines in vitro and inhibits COUP-TFII activity to regulate its target genes.CIA-1 in vivo exhibits tumor growth inhibitory effects in a mouse model of prostate cancer xenografts. inhibitory effect on tumor growth in a xenograft mouse model of prostate cancer in vivo.
价 格:¥电议型 号:T71534产 地:中国大陆
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T71532Fondaparinux free base;化合物 Fondaparinux free baseFondaparinux free base
Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs.
价 格:¥电议型 号:T71532产 地:中国大陆
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T71521NK-611 free acid;化合物 NK-611 free acidNK-611 free acid
NK-611 free acid is a new semisynthetic analogue of etoposide, which presumably also acts through inhibition of topoisomerase II, and has been found to be more potent against several cancer cell lines in vitro than etoposide.
价 格:¥电议型 号:T71521产 地:中国大陆