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T14935ElexacaftorVX-445
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
价 格:¥电议型 号:T14935产 地:中国大陆
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T1467Acemetacin阿西美辛;TVX 1322;K-708
Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetaci
价 格:¥电议型 号:T1467产 地:中国大陆
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T13742LIvacaftor hydrateIvacaftor hydrate,VX-770 hydrate,
Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.
价 格:¥电议型 号:T13742L产 地:美洲
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T1467AcemetacinAcemetacin,TVX 1322,K-708
Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetaci
价 格:¥电议型 号:T1467产 地:美洲
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T16368NVX-207NVX-207
NVX-207 is a derivative of betulinic acid. It has anti-cancer activity.
价 格:¥电议型 号:T16368产 地:美洲
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T1979AVN944AVN944,VX-944,
AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
价 格:¥电议型 号:T1979产 地:美洲
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T2263VX661VX661,Tezacaftor,
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
价 格:¥电议型 号:T2263产 地:美洲
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T2438HMN214HMN214,IVX-214,
HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.
价 格:¥电议型 号:T2438产 地:美洲
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T2480ApabetaloneApabetalone,RVX000222,RVX-208
RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
价 格:¥电议型 号:T2480产 地:美洲
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T2509TozasertibTozasertib,VX 680,MK-0457
MK-0457 is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different kinases.
价 格:¥电议型 号:T2509产 地:美洲
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T2513VX-702VX-702,VX702,VX 702
VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifically rheumatoid arthritis (RA).
价 格:¥电议型 号:T2513产 地:美洲
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T2588IvacaftorIvacaftor,VX-770,Ivacaftor (VX-770)
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
价 格:¥电议型 号:T2588产 地:美洲
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T2595LumacaftorLumacaftor,VRT 826809,VX-809
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
价 格:¥电议型 号:T2595产 地:美洲
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T2636DecernotinibDecernotinib,VRT-831509,VX-509
Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.
价 格:¥电议型 号:T2636产 地:美洲
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T2669BerzosertibBerzosertib,VX-970,VE-822
VE-822 has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid Neoplasm, among others.
价 格:¥电议型 号:T2669产 地:美洲
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T6089NeflamapimodNeflamapimod,VX-745,
VX-745, a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.
价 格:¥电议型 号:T6089产 地:美洲
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T6090BelnacasanBelnacasan,VX-765,
VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor.
价 格:¥电议型 号:T6090产 地:美洲
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T6190TelaprevirTelaprevir,VX-950,LY-570310
Telaprevir (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).
价 格:¥电议型 号:T6190产 地:美洲
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T6388AmprenavirAmprenavir,VX-478,141W94
Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
价 格:¥电议型 号:T6388产 地:美洲
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T78240(R)-Elexacaftor;化合物 (R)-Elexacaftor(R)-VX-445;(R)-VX-445
(R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It exhibits an EC50 of 0.29 ?M for the CFTR dF508 mutation [1].
价 格:¥电议型 号:T78240产 地:中国大陆