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  • T39183Okadaic acid ammonium salt；冈田酸铵盐Okadaic acid ammonium salt

    Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50 =3.7-4 nM), PP4 (IC 50 =0.1 nM), and PP5 (IC 50 =3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation and acts as a tumor promoter. Additionally, it is involved in inducing tau phosphorylation.

    价 格：￥电议型 号：T39183产 地：中国大陆

  • T39168Epsilon-(gamma-glutamyl)-lysine；Epsilon-(gamma-glutamyl)-lysineEpsilon-(gamma-glutamyl)-lysine|||γ-G

    Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative that forms bonds between extracellular matrix (ECM) components with the assistance of the enzyme tissue transglutaminase (tTg). These bonds are implicated in the pathogenesis of certain diseases like non-diabetic kidney and glaucoma filtration.

    价 格：￥电议型 号：T39168产 地：中国大陆

  • T39164MC-betaglucuronide-MMAE-1；MC-betaglucuronide-MMAE-1MC-betaglucuronide-MMAE-1

    MC-betaglucuronide-MMAE-1 is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADCs), employing MMAE (a tubulin polymerization inhibitor) connected through the cleavable ADC linker MC-betaglucuronide.

    价 格：￥电议型 号：T39164产 地：中国大陆

  • T39125MC-VC-PAB-Tubulysin M；MC-VC-PAB-Tubulysin MMC-VC-PAB-Tubulysin M

    MC-vc-PAB-Tubulysin M is a conjugate composed of a cleavable ADC linker (MC-vc-PAB) and the cytotoxic tubulin inhibitor Tubulysin M, which inhibits tubulin polymerization, resulting in cell cycle arrest and apoptosis.

    价 格：￥电议型 号：T39125产 地：中国大陆

  • T38830Modified MMAF-C5-COOH；Modified MMAF-C5-COOHModified MMAF-C5-COOH；Modified MMAF-C5-COOH

    Modified MMAF-C5-COOH is a drug-linker conjugate for ADC.

    价 格：￥电议型 号：T38830产 地：中国大陆

  • T38828MesdopetamMesdopetamIRL790

    Mesdopetam (IRL790) is a dopamine D3 receptor antagonist with a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It exhibits psychomotor stabilizing properties and is utilized in the study of motor and psychiatric complications associated with Parkinson´s disease.

    价 格：￥电议型 号：T38828产 地：中国大陆

  • T38800MMPI-1154；MMPI-1154MMPI-1154

    MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. Additionally, MMPI-1154 exhibits significant inhibitory effects on MMP-13, MMP-1, and MMP-9 activities with IC 50 values of 1.8 μM, 10 μM, and 13 μM, respectively.

    价 格：￥电议型 号：T38800产 地：中国大陆

  • T3869Skimmin；茵芋苷Skimmine；茵芋苷|||Skimmine

    Skimmin (Skimmine) has anti-inflammatory activity, can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis.

    价 格：￥电议型 号：T3869产 地：中国大陆

  • T38635Kdo2-Lipid A ammonium；Kdo2-Lipid A铵盐Kdo2-Lipid A ammonium

    Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.

    价 格：￥电议型 号：T38635产 地：中国大陆

  • T38570DMAPP triammonium；DMAPP三铵盐Dimethylallyl diphosphate triammonium|||Dimethylallyl Pyrophosphate triamm

    DMAPP triammonium (Dimethylallyl diphosphate triammonium) is one of the prerequisite substances for an isoprenoid involved in the mevalonate (MVA) pathway, which can be used in the study of metabolism-related diseases.

    价 格：￥电议型 号：T38570产 地：中国大陆

  • T38482MM 419447；MM 419447MM 419447

    MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.

    价 格：￥电议型 号：T38482产 地：中国大陆

  • T38478Mevalonic acid 5-pyrophosphate tetralithium；Mevalonic acid 5-pyrophosphate tetralithiumMevalonicacid

    Mevalonic acid 5-pyrophosphate (also known as 5-Diphosphomevalonic acid) tetralithium is an endogenous metabolite involved in the mevalonate pathway.

    价 格：￥电议型 号：T38478产 地：中国大陆

  • T38474CL2-MMT-SN38；CL2-MMT-SN38CL2-MMT-SN38；CL2-MMT-SN38

    CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.

    价 格：￥电议型 号：T38474产 地：中国大陆

  • T38473Malonyl Coenzyme A lithium；Malonyl Coenzyme A lithiumMalonyl Coenzyme A lithium

    Malonyl Coenzyme A (lithium) is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl Coenzyme A (lithium) is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl Coenzyme A (lithium) is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.

    价 格：￥电议型 号：T38473产 地：中国大陆

  • T38428Alisertib sodium；Alisertib sodiumMLN 8237 sodium；MLN 8237 sodium

    Alisertib sodium (MLN 8237) is a potent and specific inhibitor (IC50 = 1.2 nM) of Aurora A kinase, an enzyme involved in cell division. By binding to Aurora A kinase, Alisertib sodium disrupts the formation of the mitotic spindle and causes abnormal cell division. At the molecular level, it acts on the AKT/mTOR/AMPK/p38 pathway, leading to the induction of apoptosis and autophagy in leukemic cells. This compound exhibits significant antitumor activity.

    价 格：￥电议型 号：T38428产 地：中国大陆

  • T38331Commendamide；CommendamideCommendamide

    Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 μM.

    价 格：￥电议型 号：T38331产 地：中国大陆

  • T38024Gamma-glutamylcysteine；gamma-Glu-CysGamma-glutamylcysteine

    Gamma-glutamylcysteine is a natural product for research related to life sciences. The catalog number is T38024 and the CAS number is 636-58-8.

    价 格：￥电议型 号：T38024产 地：中国大陆

  • T37964Dicresulene diammonium；Dicresulene diammoniumDicresulene diammonium

    Dicresulene diammonium is an impurity found in Policresulen, which is an organic acid possessing hemostatic, antimicrobial, and antiviral properties[1][2].

    价 格：￥电议型 号：T37964产 地：中国大陆

  • T37775Farnesyl Pyrophosphate (ammonium salt)；Farnesyl Pyrophosphate (ammonium salt)Farnesyl Pyrophosphate

    Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols. It also serves as a donor in post-translational isoprenylation of proteins. FPP has been identified as an antagonist of P2Y12 receptors (IC50 = 45 μM), attenuating platelet aggregation. It has also been shown to regulate adipocyte function as an endogenous PPARγ agonist. Additionally, because of a flexible hydrocarbon chain that enables different conformat

    价 格：￥电议型 号：T37775产 地：中国大陆

  • T37726MMP-9 Inhibitor I；MMP-9 Inhibitor IMMP-9 Inhibitor I

    MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.

    价 格：￥电议型 号：T37726产 地：中国大陆

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