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  • T78728SP27；化合物 SP27SP27

    SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].

    价 格：￥电议型 号：T78728产 地：中国大陆

  • T78719SARS-CoV-2-IN-47；化合物 SARS-CoV-2-IN-47SARS-CoV-2-IN-47

    SARS-CoV-2-IN-47 (Compound 13), with IC50 values of 0.77 μM against Omicron BA.1 and 0.93 μM against the Delta strain, serves as an inhibitor of SARS-CoV-2 and is applicable in antiviral research [1].

    价 格：￥电议型 号：T78719产 地：中国大陆

  • T77924SB1-G-187；化合物 SB1-G-187SB1-G-187

    SB1-G-187 is a PROTAC (PROteolysis TArgeting Chimera) that functions as a multi-kinase degrader [1].

    价 格：￥电议型 号：T77924产 地：中国大陆

  • T77011Flanvotumab；夫兰妥单抗20D7S|||IMC 20D7S；20D7S|||IMC 20D7S

    Flanvotumab (IMC-20D7S) is a humanized monoclonal antibody directed against tyrosinase-related protein (TYRP1).Flanvotumab exhibits potent antitumor activity and acts through natural killer-mediated and antibody-dependent cell-mediated cytotoxicity (ADCC).

    价 格：￥电议型 号：T77011产 地：中国大陆

  • T76877Vofatamab；沃凡妥单抗RG-7444|||B-701|||MFGR-1877S；RG-7444|||B-701|||MFGR-1877S

    Vofatamab (B-701) is a fully human monoclonal antibody targeting FGFR3. Vofatamab has potential anticancer and antitumor activity and is often used in combination with other compounds to treat cancer.

    价 格：￥电议型 号：T76877产 地：中国大陆

  • T75095STING agonist-27；化合物 STING agonist-27STING agonist-27

    STING agonist-27 (CF509) is a non-nucleotide, small-molecule agonist of STING, which activates STING and demonstrates activity against SARS-CoV series strains [1].

    价 格：￥电议型 号：T75095产 地：中国大陆

  • T74994SJ988497；化合物 SJ988497SJ988497

    SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker, and the CRBN ligand Pomalidomide, SJ988497 is utilized in researching acute lymphoblastic leukemia (ALL) [1].

    价 格：￥电议型 号：T74994产 地：中国大陆

  • T74945SARS-CoV-2-IN-27；化合物 SARS-CoV-2-IN-27SARS-CoV-2-IN-27

    SARS-CoV-2-IN-27, a diphosphate ester featuring a C6 alkyl chain and extended-length molecular tweezers, demonstrates antiviral efficacy, with IC50 values of 1.0 μM and 1.7 μM against SARS-CoV-2 activity and spike pseudoparticle transduction, respectively. Additionally, it disrupts liposomal membranes, evidenced by an EC50 of 6.5 μM [1].

    价 格：￥电议型 号：T74945产 地：中国大陆

  • T74937Sirt2-IN-7；化合物 Sirt2-IN-7Sirt2-IN-7

    Sirt2-IN-7 (compound 22) is a selective SIRT2 inhibitor with an IC50 of 178.2 nM and a Ki of 154.3 nM, utilized in cancer research [1].

    价 格：￥电议型 号：T74937产 地：中国大陆

  • T74508SS47；化合物 SS47SS47

    SS47, a PROTAC -based HPK1 degrader , exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the?in?vivo?antitumor efficacy of BCMA CAR-T cell research. HPK1, an?immunosuppressive?regulatory kinase, is a promising target for cancer immunotherapies [1] .

    价 格：￥电议型 号：T74508产 地：中国大陆

  • T74489SIAIS117；化合物 SIAIS117SIAIS117

    SIAIS117, a potent Brigatinib-PROTAC degrader, effectively degrades the ALK G1202R point mutation through its design based on Brigatinib and VHL-1 conjunction. It inhibits the proliferation of SR and H2228 cancer cell lines, demonstrating potential anti-proliferative effects against small cell lung cancer [1].

    价 格：￥电议型 号：T74489产 地：中国大陆

  • T74375PROTAC ERα Y537S degrader-1；化合物 PROTAC ERα Y537S degrader-1PROTAC ERα Y537S degrader-1

    PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader [1] .

    价 格：￥电议型 号：T74375产 地：中国大陆

  • T74267STING agonist-17；化合物 STING agonist-17STING agonist-17

    STING agonist-17 (compound 4a) is a highly potent stimulator of the STING pathway, exhibiting an IC 50 of 0.062 nM. It demonstrates significant anti-cancer properties, promoting tumor immunization [1].

    价 格：￥电议型 号：T74267产 地：中国大陆

  • T7396Substance P(1-7)；化合物Substance P 1-7Substance P 1-7；Substance P 1-7

    Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

    价 格：￥电议型 号：T7396产 地：中国大陆

  • T73443STL1267；化合物 STL1267STL1267

    STL1267, a potent REV-ERB agonist capable of crossing the blood-brain barrier, exhibits a K i value of 0.16 ?M for REV-ERBα without demonstrating cytotoxicity. It effectively inhibits the gene expression of BMAL1.

    价 格：￥电议型 号：T73443产 地：中国大陆

  • T73286SRI-42127；化合物 SRI-42127SRI-42127

    SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.

    价 格：￥电议型 号：T73286产 地：中国大陆

  • T73114STAT3-IN-7；化合物 STAT3-IN-7STAT3-IN-7

    STAT3-IN-7, an orally active aryl sulfonamido azetidine compound, serves as a STAT3 inhibitor with anticancer activities.

    价 格：￥电议型 号：T73114产 地：中国大陆

  • T72788EGFR/C797S-IN-1；化合物 EGFR/C797S-IN-1EGFR/C797S-IN-1

    EGFR/C797S-IN-1 is a potent inhibitor targeting the EGFR-C797S mutation, demonstrated by its IC 50 value of 0.128 ?M. This compound exhibits significant anti-proliferative and anti-tumor effects by inhibiting p-EGFR expression in a dose-dependent manner.

    价 格：￥电议型 号：T72788产 地：中国大陆

  • T72371SARS-CoV-2 3CLpro-IN-7；化合物 SARS-CoV-2 3CLpro-IN-7SARS-CoV-2 3CLpro-IN-7

    SARS-CoV-2 3CLpro-IN-7 is a reversible covalent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an inhibitory concentration (IC50) value of 1.4 ?M.

    价 格：￥电议型 号：T72371产 地：中国大陆

  • T72003SKF-104557；化合物 SKF-104557SKF-104557

    N-Despropyl ropinirole is an active metabolite of the dopamine D2 receptor agonist ropinirole. It increases extracellular acidification rates in CHO cells expressing human dopamine D2, D3, and D4 receptors (EC50s = 0.63, 0.063, and 1.23 ?M, respectively). N-Despropyl ropinirole is also a potential impurity found in commercial preparations of ropinirole.

    价 格：￥电议型 号：T72003产 地：中国大陆

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