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  • T68767Mezilamine HCl；化合物 Mezilamine HClMezilamine HCl

    Mezilamine HCl is a dopamine antagonist, blocking presynaptic but stimulating postsynaptic alpha-adrenoceptors.

    价 格：￥电议型 号：T68767产 地：中国大陆

  • T68761Cloricromen hydrochloride；化合物 Cloricromen HClCloricromene hydrochloride|||Cloricromen hydrochloride；

    Cloricromen hydrochloride, also known as Cloricromene hydrochloride, is a compound that functions as a platelet aggregation inhibitor, effectively preventing platelet aggregation in both humans and experimental thrombosis scenarios.

    价 格：￥电议型 号：T68761产 地：中国大陆

  • T68743AZD4877 HCl；化合物 AZD4877 HClAZD4877 HCl

    AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur

    价 格：￥电议型 号：T68743产 地：中国大陆

  • T68708Denibulin HCl；化合物 Denibulin HClDenibulin HCl

    Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.

    价 格：￥电议型 号：T68708产 地：中国大陆

  • T68706Olanzapine HCl；化合物 Olanzapine HClOlanzapine HCl

    Olanzapine HCl is an atypical antipsychotic. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder. Olanzapine is structurally similar to clozapine and quetiapine. It is a dopamine antagonist and is classified as a thienobenzodiazepine.

    价 格：￥电议型 号：T68706产 地：中国大陆

  • T6857HLCL-61 hydrochloride；化合物HLCL-61 hydrochlorideHLCL61|||HLCL-61 HCL；HLCL61|||HLCL-61 HCL

    HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.

    价 格：￥电议型 号：T6857产 地：中国大陆

  • T68568Encequidar, HCl；化合物 Encequidar, HClEncequidar, HCl

    Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials.

    价 格：￥电议型 号：T68568产 地：中国大陆

  • T68550SKF89976A HCl；化合物 SKF89976A HClSKF89976A HCl

    SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.

    价 格：￥电议型 号：T68550产 地：中国大陆

  • T68544FK-375 HCl；化合物 FK-375 HClFK-375 HCl

    FK-375 HCl is an inhibitor of chymotrypsin.

    价 格：￥电议型 号：T68544产 地：中国大陆

  • T68543FK-386 HCl；化合物 FK-386 HClFK-386 HCl

    FK-386 HCl is an inhibitor of chymotrypsin.

    价 格：￥电议型 号：T68543产 地：中国大陆

  • T68532ICI-147798 HCl；化合物 ICI-147798 HClICI-147798 HCl

    ICI-147798 HCl is a beta adrenoceptor antagonist.

    价 格：￥电议型 号：T68532产 地：中国大陆

  • T68518Diprafenone HCl；化合物 Diprafenone HClDiprafenone HCl

    Diprafenone HCl is the salt form of Diprafenone Free Base, an antiarrhythmic beta adrenergic antagonist.

    价 格：￥电议型 号：T68518产 地：中国大陆

  • T68485Apilimod HCl；化合物 Apilimod HClApilimod HCl

    Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions. It reduces the number of SARS-CoV-2-infected hiPSC-derived pneumocyte-like cells by 85% and inhibits SARS-CoV-2 replication in donor lung tissue. It also exhibits selective cytotoxicity in B-cell non-Hodgkin lymphoma

    价 格：￥电议型 号：T68485产 地：中国大陆

  • T68474RWJ-58643 HCl；化合物 RWJ-58643 HClRWJ-58643 HCl

    RWJ 58643 is a reversible beta-tryptase and trypsin inhibitor. Low-dose RWJ-58643 (100 microg) and budesonide (200 microg) significantly reduced symptoms, eosinophils and levels of IL-5 following NAC. However, higher doses of RWJ-58643 (300 and 600 microg) caused a late eosinophilia and preceding increases in IL-5 compared with placebo.

    价 格：￥电议型 号：T68474产 地：中国大陆

  • T68456Dexlofexidine HCl；化合物 Dexlofexidine HClDexlofexidine HCl

    Dexlofexidine HCl is the salt form of Dexlofexidine Free Base, an isomer “+“ of lofexidine, which is an agonist of alpha 2-adrenoceptor, but in 10 times less potent than the other isomer, levlofexidine

    价 格：￥电议型 号：T68456产 地：中国大陆

  • T68435Cilazapril HCl；化合物 Cilazapril HClCilazapril HCl

    Cilazapril, also known as Ro 31 2848, is a potent ACE inhibitor used for hypertension. Cilazapril is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. Cilazapril is a monoethyl ester, which acts as an angiotensin-converting enzyme (ACE) inhibitor. The inhibitor functions by inhibiting the ability of ACE to cleave bonds of angiotensin I and Hip-His-Leu. It is known that the diacid form of Cilazapril is more potent that enalapril at inhibiting ACE.

    价 格：￥电议型 号：T68435产 地：中国大陆

  • T6840LFRAX486 HCL(1232030-35-1 free base)；化合物FRAX486FRAX486 HCL(1232030-35-1 free base)

    FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.

    价 格：￥电议型 号：T6840L产 地：中国大陆

  • T68371Rolapitant hydrochloride hydrate；化合物 Rolapitant HClRolapitant hydrochloride hydrate

    Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of

    价 格：￥电议型 号：T68371产 地：中国大陆

  • T6837Flavopiridol；夫拉平度L868275|||Alvocidib|||NSC 649890 HCl|||HMR-1275；L868275|||Alvocidib|||夫拉平度|||NSC 64

    Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.

    价 格：￥电议型 号：T6837产 地：中国大陆

  • T68365Indimitecan HCl；化合物 Indimitecan HClIndimitecan HCl

    Indimitecan HCl is a TOP1 inhibitor chemical scaffold.

    价 格：￥电议型 号：T68365产 地：中国大陆

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