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  • T69973PF-04363467 HCl；化合物 PF-04363467 HClPF-04363467 HCl

    PF-04363467 HCl is a selective dopamine D3/D2 receptor antagonist.

    价 格：￥电议型 号：T69973产 地：中国大陆

  • T69955JPI-547 HCl；化合物 JPI-547 HClJPI-547 HCl

    JPI 547, also known as NOV 1402, is an oral inhibitor of PARP 1/2 and Tankyrase 1/2. JPI-547 demonstrated anti-tumor activity in BRCA-deficient xenograft models as a single-agent and in combination with chemotherapy and immune checkpoint inhibitors.

    价 格：￥电议型 号：T69955产 地：中国大陆

  • T69944NLG802 HCl；化合物 NLG802 HClNLG802 HCl

    NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod res

    价 格：￥电议型 号：T69944产 地：中国大陆

  • T69942CN-716 HCl；化合物 CN-716 HClCN-716 HCl

    cn-716 is a novel Zika virus (ZIKV) NS2B-NS3pro protease inhibitor.

    价 格：￥电议型 号：T69942产 地：中国大陆

  • T69934Etoloxamine HCl；化合物 Etoloxamine HClEtoloxamine HCl

    Etoloxamine HCl is the salt form of Etoloxamine free base, a histamine 1 receptor antagonist.

    价 格：￥电议型 号：T69934产 地：中国大陆

  • T69922EPZ020411 HCl；化合物 EPZ020411 HClEPZ020411 HCl

    EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies. EPZ020411 suppresses RCC1 arginine methylation and improves the cytotoxic activity of radiotherapy against GSC brain tumor xenografts.

    价 格：￥电议型 号：T69922产 地：中国大陆

  • T69908Pidnarulex HCl；化合物 Pidnarulex HClPidnarulex HCl

    Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. T

    价 格：￥电议型 号：T69908产 地：中国大陆

  • T69905Iferanserin HCl；化合物 Iferanserin HClIferanserin HCl

    Iferanserin HCl is a selective serotonin receptor antagonist.

    价 格：￥电议型 号：T69905产 地：中国大陆

  • T6988SKF 38393 hydrochloride；化合物SKF38393 HCl(±)-SKF-38393 hydrochloride|||SKF-38393A|||SKF38393 HCl；(±)-S

    SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.

    价 格：￥电议型 号：T6988产 地：中国大陆

  • T69862Afeletecan HCl；化合物 Afeletecan HClAfeletecan HCl

    Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA repli

    价 格：￥电议型 号：T69862产 地：中国大陆

  • T69852CS-003 HCl；化合物 CS-003 HClCS-003 HCl

    CS-003 HCl is a TNRA - triple neurokinin receptor antagonist.

    价 格：￥电议型 号：T69852产 地：中国大陆

  • T69842DB2313 HCl；化合物 DB2313 HClDB2313 HCl

    DB2313 is a first-in-class potent small-molecule inhibitor of PU.1. DB2313 disrupts the interaction of PU.1 with target gene promoters and leads to down-regulation of canonical PU.1 transcriptional targets.

    价 格：￥电议型 号：T69842产 地：中国大陆

  • T69836Paltusotine HCl；化合物 Paltusotine HClPaltusotine HCl

    Paltusotine, also known as CRN00808, is a somatostatin receptor agonist.

    价 格：￥电议型 号：T69836产 地：中国大陆

  • T69825Dexetimide HCl；化合物 Dexetimide HClDexetimide HCl

    Dexetimide HCl is a muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.

    价 格：￥电议型 号：T69825产 地：中国大陆

  • T69810N-2733 HCl；化合物 N-2733 HClN-2733 HCl

    N-2733 HCl is a nuclear factor (NF)-kappaB activation inhibitor.

    价 格：￥电议型 号：T69810产 地：中国大陆

  • T697984-Me-PDTic HCl；化合物 4-Me-PDTic HCl4-Me-PDTic HCl

    4-Me-PDTic is a potent and selective Kappa Opioid Receptor Antagonist. 4-Me-PDTic had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors, respectively. Calculated logBB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 4-Me-PDTic will penetrate the brain and pharmacokinetic studies in rats shows that 4-Me-PDTic does indeed penetrate the brain.

    价 格：￥电议型 号：T69798产 地：中国大陆

  • T69784GSK3527497 HCl；化合物 GSK3527497 HClGSK3527497 HCl

    GSK3527497 is a potent and selective inhibitor of Transient Receptor Potential Vanilloid?4 (TRPV4) with IC50 = 12 nM) for the treatment of heart failure and respiratory diseases. GSK3527497 is a preclinical candidate suitable for oral and iv administration that is projected to inhibit TRPV4 effectively in patients from a low daily clinical dose.

    价 格：￥电议型 号：T69784产 地：中国大陆

  • T69766Gusacitinib HCl；化合物 Gusacitinib HClGusacitinib HCl

    Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and

    价 格：￥电议型 号：T69766产 地：中国大陆

  • T69741DWN-12088 HCl；化合物 DWN-12088 HClDWN-12088 HCl

    DWN-12088 HCl is the salt form of DWN-12088 Free Base, an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitor

    价 格：￥电议型 号：T69741产 地：中国大陆

  • T69712Icapamespib HCl；化合物 Icapamespib HClIcapamespib HCl

    Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans.

    价 格：￥电议型 号：T69712产 地：中国大陆

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