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T70411PS372424 HCl；化合物 PS372424 HClPS372424 HCl
PS372424 is a specific agonist of human CXCR3. It has been shown to induce phosphorylation of ERK and block CXCL11 induced migration of CD45+ cells to air pouches generated on humanized mice.
价 格：￥电议型 号：T70411产 地：中国大陆
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T70394Deucravacitinib HCl；化合物 Deucravacitinib HClDeucravacitinib HCl
Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional resp
价 格：￥电议型 号：T70394产 地：中国大陆
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T70391AMG151 HCl；化合物 AMG151 HClAMG151 HCl
ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse
价 格：￥电议型 号：T70391产 地：中国大陆
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T70385CGS-27023A HCl；化合物 CGS-27023A HClCGS-27023A HCl
CGS-27023A is a novel matrix metalloproteinase inhibitor.
价 格：￥电议型 号：T70385产 地：中国大陆
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T70382KBP-7018 HCl；化合物 KBP-7018 HClKBP-7018 HCl
KBP-7018 Hydrochloride is a novel, tyrosine kinase-selective inhibitor with potent effects on three fibrotic kinases (c-KIT, PDGFR, and RET).
价 格：￥电议型 号：T70382产 地：中国大陆
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T70377BAY 61-3606 HCl；化合物 BAY 61-3606 HClBAY 61-3606 HCl
BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used i
价 格：￥电议型 号：T70377产 地：中国大陆
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T70304CI-898 HCl；化合物 CI-898 HClCI-898 HCl
CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
价 格：￥电议型 号：T70304产 地：中国大陆
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T70295MDL-105212A HCl；化合物 MDL-105212A HClMDL-105212A HCl
MDL-105212A HCl is a nonpeptide NK-1 and NK-2 receptor antagonist.
价 格：￥电议型 号：T70295产 地：中国大陆
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T70293KAA-276 HCl；化合物 KAA-276 HClKAA-276 HCl
KAA-276 HCl is the salt form of KAA-276 free base, a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.
价 格：￥电议型 号：T70293产 地：中国大陆
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T70292DDPM-2571 HCl；化合物 DDPM-2571 HClDDPM-2571 HCl
DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and was highly effective in the prevention of chemically-induced seizures (pentylenetetrazole and pilocarpine models) and 6-Hz convulsions. It demonstrated significant anxiolytic-like and antidepressant-like properties. DDPM-2571 had antinociceptive properties, both in the hot plate
价 格：￥电议型 号：T70292产 地：中国大陆
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T70273APTO-253 HCl；化合物 APTO-253 HClAPTO-253 HCl
APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor
价 格：￥电议型 号：T70273产 地：中国大陆
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T70267ADL 08-0011 HCl；化合物 ADL 08-0011 HClADL 08-0011 HCl
ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverse
价 格：￥电议型 号：T70267产 地：中国大陆
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T70257Avitriptan HCl；化合物 Avitriptan HClAvitriptan HCl
Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.
价 格：￥电议型 号：T70257产 地：中国大陆
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T70233Efegatran HCl；化合物 Efegatran HClEfegatran HCl
Efegatran, also known as GYKI-14166, RGH-2958 and LY294468, a thrombin inhibitor which is being developed by IVAX for the potential treatment of thromboembolic disorders.
价 格：￥电议型 号：T70233产 地：中国大陆
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T70231Osanetant HCl；化合物 Osanetant HClOsanetant HCl
Osanetant HCl is the (R)-enantiomer; neurokinin-3 receptor antagonist
价 格：￥电议型 号：T70231产 地：中国大陆
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T70202DDR1-IN-1 dihydrochloride；化合物 DDR1-IN-1 HClDDR1-IN-1 dihydrochloride
DDR1-IN-1 dihydrochloride is a selective and potent inhibitor of the DDR1 receptor tyrosine kinase, exhibiting an IC50 of 105 nM. It demonstrates fourfold reduced potency against DDR2, with an IC50 of 413 nM.
价 格：￥电议型 号：T70202产 地：中国大陆
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T70200VU590 HCl；化合物 VU590 HClVU590 HCl
VU590 is a small molecule inhibitor of KCNJ1 (IC50 = 294 nM).
价 格：￥电议型 号：T70200产 地：中国大陆
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T70199Enecadin HCl；化合物 Enecadin HClEnecadin HCl
Enecadin HCl is a voltage-dependent sodium and calcium channel blocker.
价 格：￥电议型 号：T70199产 地：中国大陆
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T70196AZD1446 HCl；化合物 AZD1446 HClAZD1446 HCl
AZD1446 HCl, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 HCl showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer´s disease.
价 格：￥电议型 号：T70196产 地：中国大陆
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T70193APC-366 HCl；化合物 APC-366 HClAPC-366 HCl
APC-366 is a selective inhibitor of the mast cell tryptase that inhibits tryptase-induced histamine release from human tonsil and lung cells.
价 格：￥电议型 号：T70193产 地：中国大陆
