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  • T70190Tinostamustine HCl；化合物 Tinostamustine HClTinostamustine HCl

    Tinostamustine, also known as EDO-S101, is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. EDO-S101 is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and/or may help to overcome resistance to other therapeutic agents.

    价 格：￥电议型 号：T70190产 地：中国大陆

  • T70174Pirlindole-d4 HCl；化合物 Pirlindole-d4 HClPirlindole-d4 HCl

    Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru

    价 格：￥电议型 号：T70174产 地：中国大陆

  • T70168Tofacitinib HCl；化合物 Tofacitinib HClTofacitinib HCl

    Tofacitinib HCl, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib HCl modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib HCl inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.

    价 格：￥电议型 号：T70168产 地：中国大陆

  • T70164LASSBio-1829 HCl；化合物 LASSBio-1829 HClLASSBio-1829 HCl

    LASSBio-1829 HCl is an orally active IKK2 inhibitor.

    价 格：￥电议型 号：T70164产 地：中国大陆

  • T70161Berotralstat HCl；化合物 Berotralstat HClBerotralstat HCl

    Berotralstat HCl is a novel selective inhibitor of plasma kallikrein, blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE.

    价 格：￥电议型 号：T70161产 地：中国大陆

  • T70124Tomivosertib HCl；化合物 Tomivosertib HClTomivosertib HCl

    Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling.

    价 格：￥电议型 号：T70124产 地：中国大陆

  • T70096AEG40730 HCl；化合物 AEG40730 HClAEG40730 HCl

    AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in RIP1 ubiquitination. Treatment with nanomolar concentrations of AEG40730 resulted in the loss of both XIAP and c-IAP1 proteins, albeit with different kinetics.

    价 格：￥电议型 号：T70096产 地：中国大陆

  • T70077Fadolmidine HCl；化合物 Fadolmidine HClFadolmidine HCl

    Fadolmidine, also known as MPV-2426, is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia. Fadolmidine displayed high affinity and full agonist efficacy at all three human alpha2-adrenoceptor subtypes (A, B and C) in transfected CHO cells with EC50 values (nM) of 0.4, 4.9 and 0.5, respectively. Fadolmidine inhibited also electrically evoked contractions in rat vas deferens demonstrating the activation of rodent presynaptic alpha2D-adrenoceptors with an

    价 格：￥电议型 号：T70077产 地：中国大陆

  • T70063GYKI 52466 HCl；化合物 GYKI 52466 HClGYKI 52466 HCl

    GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 ?M) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 ?M but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 ?M).2 GYKI 52466 (10 ?M) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general

    价 格：￥电议型 号：T70063产 地：中国大陆

  • T7005LUlixertinib hydrochloride化合物 T7005LUlixertinib HCl|||BVD-523|||VRT752271|||BVD 523|||BVD523|||VRT 75

    Ulixertinib is an inhibitor of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival.

    价 格：￥电议型 号：T7005L产 地：中国大陆

  • T70059ALT-946 HCl；化合物 ALT-946 HClALT-946 HCl

    ALT-946 HCl is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.

    价 格：￥电议型 号：T70059产 地：中国大陆

  • T70044LSarizotan 2HCl；Sarizotan 2盐酸盐Sarizotan 2HCl

    Sarizotan 2HCl is an hERG channel inhibitor and 5-hydroxytryptamine 5-HT1A receptor agonist with potential antidepressant effects for the study of Parkinsonian movement disorders.

    价 格：￥电议型 号：T70044L产 地：中国大陆

  • T70044Sarizotan HCl；Sarizotan 盐酸盐EMD 128130 HCl；EMD 128130 HCl

    Sarizotan HCl (EMD 128130 HCl) is an hERG channel inhibitor and 5-hydroxytryptamine 5-HT1A receptor agonist with potential antidepressant effects for the study of Parkinson´s Dyskinesia.

    价 格：￥电议型 号：T70044产 地：中国大陆

  • T70036AJG-049 HCl；化合物 AJG-049 HClAJG-049 HCl

    AJG-049 HCl is a calcium channel antagonist that inhibits L-type Ca2+ channels via diltiazem-binding site(s).

    价 格：￥电议型 号：T70036产 地：中国大陆

  • T70000Ebopiprant HCl；化合物 Ebopiprant HClEbopiprant HCl

    Ebopiprant, also known as OBE-022, is an Oral and Selective Prostaglandin F 2α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor. OBE022 exhibits potent tocolytic effects on human tissues ex vivo and animal models in vivo without causing the adverse fetal side effects seen with indomethacin.

    价 格：￥电议型 号：T70000产 地：中国大陆

  • T69995Chlorhexidine-d8 HCl；化合物 Chlorhexidine-d8 HClChlorhexidine-d8 HCl

    Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC

    价 格：￥电议型 号：T69995产 地：中国大陆

  • T69991Difenamizole HCl；化合物 Difenamizole HClDifenamizole HCl

    Difenamizole HCl is the salt form of Difenamizole, a non-steroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K+-induced striatal dopamine release, and inhibition of the reuptake of dopamine.

    价 格：￥电议型 号：T69991产 地：中国大陆

  • T69986BMS-955176 HCl；化合物 BMS-955176 HClBMS-955176 HCl

    GSK-3532795 is a second generation inhibitor of hiv-1 maturation, exhibiting a broader spectrum of antiviral effect in vitro and in clinical studies than the prototypical maturation inhibitor bevirimat

    价 格：￥电议型 号：T69986产 地：中国大陆

  • T69985Lifirafenib HCl；化合物 Lifirafenib HClLifirafenib HCl

    Lifirafenib, also known as Beigene-283, is a Novel potent and selective RAF Kinase and EGFR inhibitor. BGB-283-displays Potent Antitumor Activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 potently inhibits B-RAFV600E-activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harbouring B-RAFV600E and EGFR mutation/amplification. In B-RAFV600E CRC cell lines, BGB-283 effectively inhibits the

    价 格：￥电议型 号：T69985产 地：中国大陆

  • T69978Brostallicin HCl；化合物 Brostallicin HClBrostallicin HCl

    Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent

    价 格：￥电议型 号：T69978产 地：中国大陆

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