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  • T70724GSK-2256098 HCl；化合物 GSK-2256098 HClGSK-2256098 HCl

    GSK-2256098 HCl is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.

    价 格：￥电议型 号：T70724产 地：中国大陆

  • T70712PF-06412154 HCl；化合物 PF-06412154 HClPF-06412154 HCl

    PF-06412154 HCl is a glucagon receptor antagonist.

    价 格：￥电议型 号：T70712产 地：中国大陆

  • T70702JQ1-Acid HCl；化合物 JQ1-Acid HClJQ1-Acid HCl

    (+)-JQ-1 carboxylic acid is a potent bromodomain and extra terminal domain (BET) inhibitor. (+)-JQ-1 carboxylic has potential to be used as a precursor to synthesize PROTACs and other conjugates.

    价 格：￥电议型 号：T70702产 地：中国大陆

  • T70693MRT-92 HCl salt；化合物 MRT-92 HCl saltMRT-92 HCl salt

    MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs that bind to a long and narrow cavity in the 7-transmembrane (7TM) domain.

    价 格：￥电议型 号：T70693产 地：中国大陆

  • T70660Azalanstat HCl；化合物 Azalanstat HClAzalanstat HCl

    Azalanstat HCl is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat HCl has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered l

    价 格：￥电议型 号：T70660产 地：中国大陆

  • T70646Deltarasin HCl；化合物 Deltarasin HClFK-352|||Deltarasin HCl|||FK352；FK-352|||Deltarasin HCl|||FK352

    Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF signaling in human pancreatic ductal adenocarcinoma cell lines. The anti-cancer cell activity of deltarasin can be enhanced by simultaneously blocking tumor protective" autophagy

    价 格：￥电议型 号：T70646产 地：中国大陆

  • T70643GT-0198 HCl；化合物 GT-0198 HClGT-0198 HCl

    GT-0198 is a novel glycine transporter 2 inhibitor showed activity in a mouse model of neuropathic pain. GT-0198 inhibited the function of glycine transporter 2 (GlyT2) in human GlyT2-expressing HEK293 cells and did not bind various major transporters or receptors of neurotransmitters in a competitive manner. GT-0198 is considered to be a comparatively selective GlyT2 inhibitor. GT-0198 is a structurally novel GlyT2 inhibitor bearing a phenoxymethylbenzamide moiety with in vivo efficacy in beha

    价 格：￥电议型 号：T70643产 地：中国大陆

  • T70623Esmirtazapine HCl；化合物 Esmirtazapine HClEsmirtazapine HCl

    Esmirtazapine HCl is the salt form of Esmirtazapine, a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.

    价 格：￥电议型 号：T70623产 地：中国大陆

  • T70622Selonsertib HCl；化合物 Selonsertib HClSelonsertib HCl

    Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis

    价 格：￥电议型 号：T70622产 地：中国大陆

  • T70621Cefditoren Pivoxil HCl；化合物 Cefditoren Pivoxil HClCefditoren Pivoxil HCl

    Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis.

    价 格：￥电议型 号：T70621产 地：中国大陆

  • T70614SLR080811 HCl；化合物 SLR080811 HClSLR080811 HCl

    SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.

    价 格：￥电议型 号：T70614产 地：中国大陆

  • T70613SLP120701 HCl；化合物 SLP120701 HClSLP120701 HCl

    SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.

    价 格：￥电议型 号：T70613产 地：中国大陆

  • T70588Tazemetostat HCl；化合物 Tazemetostat HClTazemetostat HCl

    Tazemetostat HCl is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1

    价 格：￥电议型 号：T70588产 地：中国大陆

  • T70585Cyclazosin HCl；化合物 Cyclazosin HClCyclazosin HCl

    Cyclazosin HCl is a hydrochloride composed of equimolar amounts of cyclazosin and hydrogen chloride. It has a role as an alpha1B-adrenoceptor antagonist. It contains a cyclazosin.

    价 格：￥电议型 号：T70585产 地：中国大陆

  • T70522FK-906 HCl；化合物 FK-906 HClFK-906 HCl

    FK-906 HCl is a human renin inhibitor used for the long-term treatment of patients with essential hypertension.

    价 格：￥电议型 号：T70522产 地：中国大陆

  • T70506Bupranolol HCl；化合物 Bupranolol HClBupranolol HCl

    Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 ?g/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]be

    价 格：￥电议型 号：T70506产 地：中国大陆

  • T70489Enerisant HCl；盐酸EnerisantEnerisant HCl

    Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.

    价 格：￥电议型 号：T70489产 地：中国大陆

  • T70472Filgotinib HCl hydrate；化合物 Filgotinib HCl hydrateFilgotinib HCl hydrate

    Filgotinib hydrochloride hydrate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn´s disease.

    价 格：￥电议型 号：T70472产 地：中国大陆

  • T70446Abivertinib HCl；化合物 Abivertinib HClAbivertinib HCl

    Abivertinib, also known as AC0010 and Avitinib, is a third-generation EGFR tyrosine kinase inhibitor and BTK Inhibitor that demonstrated clinical efficacy and manageable adverse events (AEs). Abivertinib inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AML cells, especially those harboring FLT3-ITD mutations. Abivertinib was also found to be more sensitive than ibrutinib in treating AML. Abivertinib may be a promising novel agent for A

    价 格：￥电议型 号：T70446产 地：中国大陆

  • T70444Edicotinib HCl；化合物 Edicotinib HClEdicotinib HCl

    Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tum

    价 格：￥电议型 号：T70444产 地：中国大陆

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