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T11737K-Ras G12C-IN-3;化合物 T11737K-Ras G12C-IN-3
Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
价 格:¥电议型 号:T11737产 地:中国大陆
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T11736K-Ras G12C-IN-2;化合物 T11736K-Ras G12C-IN-2
K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.
价 格:¥电议型 号:T11736产 地:中国大陆
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T11735K-Ras G12C-IN-1;化合物 T11735K-Ras G12C-IN-1
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
价 格:¥电议型 号:T11735产 地:中国大陆
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T11714JBJ-04-125-02;化合物 T11714JBJ-04-125-02
JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M.
价 格:¥电议型 号:T11714产 地:中国大陆
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T11713JBJ-02-112-05;化合物 T11713JBJ-02-112-05
JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].
价 格:¥电议型 号:T11713产 地:中国大陆
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T11712Jasplakinolide;肌动蛋白多聚化肽Jaspamide|||NSC-613009;Jaspamide|||NSC-613009
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
价 格:¥电议型 号:T11712产 地:中国大陆
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T1165Ethionamide乙硫异烟胺Bayer 5312|||乙硫异烟胺|||2-ethylthioisonicotinamide|||Ethinamide
Ethionamide (2-ethylthioisonicotinamide) is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall disruption and cell lysis. Ethionamide may be bacteriostatic or bactericidal in action, depending on the con
价 格:¥电议型 号:T1165产 地:中国大陆
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T11615IDO-IN-12;化合物IDO-IN-12IDO-IN-12
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
价 格:¥电议型 号:T11615产 地:中国大陆
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T11612IDH1 Inhibitor 3;化合物 T11612IDH1 Inhibitor 3
IDH1 Inhibitor 3 is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor (IC50: 45 nM for IDH1R132H).
价 格:¥电议型 号:T11612产 地:中国大陆
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T11608Epanolol;化合物 T11608Visacor|||ICI141292;Visacor|||ICI141292
Epanolol is a potent β-adrenoceptor partial agonist with a greater affinity for β1- than β2-adrenoceptors.
价 格:¥电议型 号:T11608产 地:中国大陆
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T11559HG-12-6;化合物 T11559HG-12-6
HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 (IC50: 165 nM). HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation.
价 格:¥电议型 号:T11559产 地:中国大陆
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T11529H3B-120;化合物H3B-120H3B-120
H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.
价 格:¥电议型 号:T11529产 地:中国大陆
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T11512Guanoxabenz;化合物 T11512Hydroxyguanabenz;Hydroxyguanabenz
Guanoxabenz is an α2 adrenergic receptor agonist.
价 格:¥电议型 号:T11512产 地:中国大陆
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T11490LGSK2945 hydrochloride (1438071-12-5 free base);化合物 T11490LGSK2945 hydrochloride;GSK2945 hydrochlorid
GSK2945 hydrochloride is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.
价 格:¥电议型 号:T11490L产 地:中国大陆
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T11454GPR120 modulator 2;化合物 T11454GPR120 modulator 2
GPR120 modulator 2 is useful for modulating GPR120.
价 格:¥电议型 号:T11454产 地:中国大陆
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T11453GPR120 modulator 1;化合物 T11453GPR120 modulator 1
GPR120 modulator 1 is useful for modulating GPR120.
价 格:¥电议型 号:T11453产 地:中国大陆
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T11452GPR120 Agonist 1;化合物 T11452GPR120 Agonist 1
GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GPR120 (the calcium flux assay), respectively.
价 格:¥电议型 号:T11452产 地:中国大陆
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T11412IPN60090;化合物IPN60090GLS1-IN-1;GLS1-IN-1
IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.
价 格:¥电议型 号:T11412产 地:中国大陆
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T11411GLPG1205;化合物GLPG1205GLPG1205
GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity. GLPG1205 shows good PK/PD characteristics and can be used to study pulmonary fibrosis.
价 格:¥电议型 号:T11411产 地:中国大陆
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T11389Genz-123346;化合物 T11389Genz-123346
Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 value of 14 nM. Genz-123346 is a potent, orally available glucosylceramide synthase inhibitor.
价 格:¥电议型 号:T11389产 地:中国大陆