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T11371GBR 12783;化合物 T11371GBR 12783
GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats. GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.
价 格:¥电议型 号:T11371产 地:中国大陆
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T11369LGB-110 hydrochloride (1252806-70-4 free base);化合物 T11369LGB-110 hydrochloride;GB-110 hydrochloride
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
价 格:¥电议型 号:T11369L产 地:中国大陆
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T11346LG3-C12 acetate(848301-94-0 free base);化合物G3-C12 acetateG3-C12 acetate(848301-94-0 free base)
G3-C12 acetate shows anticancer activity.?is a galectin-3 binding peptide, with Kd of 88 nM.
价 格:¥电议型 号:T11346L产 地:中国大陆
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T11346G3-C12;化合物 T11346G3-C12
G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
价 格:¥电议型 号:T11346产 地:中国大陆
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T11317FPA-124;化合物 T11317FPA-124
FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis.
价 格:¥电议型 号:T11317产 地:中国大陆
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T11314Fosmanogepix;化合物 T11314APX001|||E1211;APX001|||E1211
Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
价 格:¥电议型 号:T11314产 地:中国大陆
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T11299FLT3-IN-4;化合物FLT3-IN-4FLT3 inhibitor 9u;FLT3 inhibitor 9u
FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3;?IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia.
价 格:¥电议型 号:T11299产 地:中国大陆
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T11298FLT3-IN-3;化合物FLT3-IN-3FLT3-IN-3
FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.
价 格:¥电议型 号:T11298产 地:中国大陆
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T11297LFF-10101;化合物FF-10101FF-10101
FF-10101 is a potent inhibitor of FLT3.
价 格:¥电议型 号:T11297L产 地:中国大陆
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T11297FF-10101 succinate;化合物 T11297FF-10101 succinate
FF-10101 succinate is a potent FLT3 inhibitor.
价 格:¥电议型 号:T11297产 地:中国大陆
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T11296Flosulide;化合物 T11296ZK 38997|||CGP 28238;ZK 38997|||CGP 28238
Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.
价 格:¥电议型 号:T11296产 地:中国大陆
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T11295Flibanserin-d4;化合物 T11295BIMT-17BS D4|||BIMT-17 D4|||Flibanserin D4;BIMT-17BS D4|||BIMT-17 D4|||Flib
Flibanserin, a compound identified as BIMT-17, acts as a complete agonist at the serotonin 5-HT1A receptor, with a binding affinity (Ki) of 1 nM, while functioning as an antagonist at the 5-HT2A receptor with a 49 nM affinity. Flibanserin D4 represents a deuterium-labeled version of Flibanserin.
价 格:¥电议型 号:T11295产 地:中国大陆
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T11294Flavanone hydrazone;化合物 T11294Flavanone hydrazone
Flavanone hydrazine is a potent non-steroidal anti-inflammatory agent that effectively inhibits lens protein-induced ocular inflammation.
价 格:¥电议型 号:T11294产 地:中国大陆
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T11293(±)-Fabesetron hydrochloride;化合物 T11293FK1052 hydrochloride;FK1052 hydrochloride
FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.
价 格:¥电议型 号:T11293产 地:中国大陆
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T11292FKBP12 PROTAC dTAG-7;化合物 T11292dTAG-7;dTAG-7
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
价 格:¥电议型 号:T11292产 地:中国大陆
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T11291FKBP12 PROTAC dTAG-13;化合物 T11291dTAG-13;dTAG-13
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.
价 格:¥电议型 号:T11291产 地:中国大陆
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T11290FK-448 Free base;化合物 T11290FK-448 Free base
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
价 格:¥电议型 号:T11290产 地:中国大陆
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T1129Benfotiamine苯磷硫胺Benzoylthiamine monophosphate|||S-Benzoylthiamine O-monophosphate|||苯磷硫胺
Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1), used as an antioxidant dietary supplement.
价 格:¥电议型 号:T1129产 地:中国大陆
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T1128L(S)-Oxiracetam;化合物 T1128L(S)-ISF-2522|||S-Oxiracetam;(S)-ISF-2522|||S-Oxiracetam
(S)-Oxiracetam is a positive allosteric the AMPA receptorsmodulator.
价 格:¥电议型 号:T1128L产 地:中国大陆
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T11289Finafloxacin;非那沙星Finafloxacin
Finafloxacin, a fluoroquinolone antimicrobial agent from a new 8-cyano subclass, is most effective in slightly acidic environments (pH 5.0-6.0), a condition where other fluoroquinolones typically reduce in activity. It selectively targets bacterial type II topoisomerases, such as DNA gyrase and DNA topoisomerase IV, making it suitable for treating serious bacterial infections particularly in acidic contexts, including urinary tract infections (UTIs) and Helicobacter pylori infections.
价 格:¥电议型 号:T11289产 地:中国大陆