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  • T61736CB1/2 agonist 3；化合物 CB1/2 agonist 3CB1/2 agonist 3

    CB1/2 agonist 3 (compound 52), a potent non-selective cannabinoid ligand, is a competitive agonist for the CB1/CB2 receptors. It exhibits CB1/CB2 agonistic activity by binding to the human CB1 and CB2 receptors, with Ki values of 5.9 nM and 3.5 nM, respectively [1].

    价 格：￥电议型 号：T61736产 地：中国大陆

  • T61442HIF-1/2α-IN-1；化合物 HIF-1/2α-IN-1HIF-1/2α-IN-1

    HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrease HIF-1α levels. This compound is particularly valuable for research on clear cell renal cell carcinoma (ccRCC) [1].

    价 格：￥电议型 号：T61442产 地：中国大陆

  • T61196COX-1/2-IN-1；化合物 COX-1/2-IN-1COX-1/2-IN-1

    COX-1/2-IN-2, a potent inhibitor of both COX-1 and COX-2, demonstrates significant inhibitory activity, with IC50 values of 13.9 ± 3.21 μM for COX-1 and 6.4 ± 0.74 μM for COX-2, respectively [1].

    价 格：￥电议型 号：T61196产 地：中国大陆

  • T61102HIF-1/2α-IN-2；化合物 HIF-1/2α-IN-2HIF-1/2α-IN-2

    HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α. This compound elicits an iron starvation response by specifically targeting ISCA2, a key protein involved in Iron Sulfur Cluster Assembly 2. [1]

    价 格：￥电议型 号：T61102产 地：中国大陆

  • T60992COX-1/2-IN-3；化合物 COX-1/2-IN-3COX-1/2-IN-3

    COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].

    价 格：￥电议型 号：T60992产 地：中国大陆

  • T60733MNK1/2-IN-5；化合物 MNK1/2-IN-5MNK1/2-IN-5

    MNK1/2-IN-5 is a potent and selective inhibitor of MNK1/2.

    价 格：￥电议型 号：T60733产 地：中国大陆

  • T60583CDK1/2/4-IN-1；化合物 CDK1/2/4-IN-1CDK1/2/4-IN-1

    CDK1/2/4-IN-1 (compound 3a) is a potent inhibitor of CDK with IC 50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 can be used in cancer research. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates the level of Bax, caspase-3, and P53 and decreases the level of Bcl-2 [1].

    价 格：￥电议型 号：T60583产 地：中国大陆

  • T60361LSD1/2-IN-4；化合物 LSD1/2-IN-4LSD1/2-IN-4

    LSD1/2-IN-4, a derivative of PCPA, functions as an inhibitor for both lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2), demonstrating K i values of 0.11 μM and 130 μM against LSD1 and LSD2, respectively. This compound is utilized in researching various cancers, notably T-cell acute lymphoblastic leukemia (TALL) [1].

    价 格：￥电议型 号：T60361产 地：中国大陆

  • T60339PKN1/2-IN-1；化合物 PKN1/2-IN-1PKN1/2-IN-1

    PKN1/2-IN-1 is a potent, cell penetrant and selective inhibitor of PKN2 /PRK2 with IC50 of 16 nM and Ki of 8 nM [1].

    价 格：￥电议型 号：T60339产 地：中国大陆

  • T40452N-Acetylpsychosine；N-AcetylpsychosineN-Acetylpsychosine|||C2 Galactosylceramide (d18:1/2:0)；N-Acetyl

    N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties. This compound, N-Acetylpsychosine, holds potential as a valuable tool for studying the mechanisms of apoptosis and immune responses activated by dendritic cells (DCs).

    价 格：￥电议型 号：T40452产 地：中国大陆

  • T4019Cambinol；化合物CambinolSIRT1/2 Inhibitor IV|||NSC 112546；SIRT1/2 Inhibitor IV|||NSC 112546

    Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Camb

    价 格：￥电议型 号：T4019产 地：中国大陆

  • T39966SGLT1/2-IN-2SGLT1/2-IN-2SGLT1/2-IN-2

    SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).

    价 格：￥电议型 号：T39966产 地：中国大陆

  • T3989SMI-16a；化合物SMI-16aPIM1/2 Kinase Inhibitor VI；PIM1/2 Kinase Inhibitor VI

    SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 μM).

    价 格：￥电议型 号：T3989产 地：中国大陆

  • T39567HDAC1/2-IN-3HDAC1/2-IN-3HDAC1/2-IN-3

    HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.

    价 格：￥电议型 号：T39567产 地：中国大陆

  • T38286C26 Sphingomyelin (d18:1/26:0)；C26 Sphingomyelin (d18:1/26:0)C26 Sphingomyelin (d18:1/26:0)；C26 Sphi

    C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.]

    价 格：￥电议型 号：T38286产 地：中国大陆

  • T38282C22 Glucosylceramide (d18:1/22:0)；C22 Glucosylceramide (d18:1/22:0)C22 Glucosylceramide (d18:1/22:0)

    C22 Glucosylceramide (d18:1/22:0) is an endogenous glucosylceramide. Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A2 (PLA2) type XIIA knockdown increases C22 glucosylceramide (d18:1/22:0) expression in rat brain. It is also increased in the brain, but not the liver or spinal cord, of mice f

    价 格：￥电议型 号：T38282产 地：中国大陆

  • T38281C22 Galactosylceramide (d18:1/22:0)；C22 Galactosylceramide (d18:1/22:0)C22 Galactosylceramide (d18:1

    C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer´s disease.2[Matreya, LLC.]

    价 格：￥电议型 号：T38281产 地：中国大陆

  • T38011C2 Adamantanyl Globotriaosylceramide (d18:1/2:0)；C2 Adamantanyl Globotriaosylceramide (d18:1/2:0)C2

    C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain. It inhibits Vero toxin binding to globotriaosylceramide in an ELISA assay when used at a concentration of 10 μM. AdaGb3 decreases cell surface expression of P-glycoprotein (P-gp) and reduces efflux of rhodamine 123 in MDCK cells. It also increases apical-to-basal transport of vinblastine in human intestinal

    价 格：￥电议型 号：T38011产 地：中国大陆

  • T37563C22 Ceramide (d18:1/22:0)；C22神经酰胺(d18：1/22：0)Cer(d18:1/22:0)|||C22 Ceramide|||Ceramide (d18:1/22:0)；

    C22 Ceramide (d18:1/22:0) (C22 Ceramide), a long-chain ceramide containing behenic acid, is an endogenous bioactive sphingolipid.C22-Ceramide specifically inhibits MCSR and reduces C16 ceramide channel formation in isolated rat liver mitochondria and liposomes.

    价 格：￥电议型 号：T37563产 地：中国大陆

  • T37440C2 Adamantanyl Galactosylceramide (d18:1/2:0)；C2 Adamantanyl Galactosylceramide (d18:1/2:0)C2 Adaman

    C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively.

    价 格：￥电议型 号：T37440产 地：中国大陆

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