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T3705GDC0084；化合物GDC-0084GDC-0084|||RG7666|||GDC 0084；GDC-0084|||RG7666|||GDC 0084
GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations.
价 格：￥电议型 号：T3705产 地：中国大陆
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T3623Cobimetinib；考比替尼RG7420|||XL518|||GDC-0973；可美替尼|||考比替尼|||RG7420|||XL518|||GDC-0973
Cobimetinib (GDC-0973) is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation.
价 格：￥电议型 号：T3623产 地：中国大陆
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T27407GDC0575 monohydrochloride；化合物GDC0575 monohydrochlorideARRY-575|||GDC-0575|||GDC 0575|||ARRY575|||GDC
GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
价 格：￥电议型 号：T27407产 地：中国大陆
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T2590Vismodegib；维莫德吉Erivedge|||GDC-0449|||RG 3616；Erivedge|||GDC-0449|||RG 3616|||维莫德吉
Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
价 格：￥电议型 号：T2590产 地：中国大陆
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T223382,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide；化合物GDC046GDC046；GDC046
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
价 格：￥电议型 号：T22338产 地：中国大陆
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T2119Venetoclax；维奈妥拉GDC-0199|||ABT 199|||ABT-199|||ABT199；GDC-0199|||ABT 199|||维奈妥拉|||ABT-199|||ABT199
Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces autophagy and apoptosis.
价 格：￥电议型 号：T2119产 地：中国大陆
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T1999Taselisib；化合物TaselisibRG-7604|||GDC-0032；RG-7604|||GDC-0032
Taselisib (GDC-0032) is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity.
价 格：￥电议型 号：T1999产 地：中国大陆
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T1994Pictilisib；化合物PictilisibRG7321|||GDC-0941；RG7321|||GDC-0941
Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).
价 格：￥电议型 号：T1994产 地：中国大陆
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T1916Apitolisib；化合物ApitolisibRG 7422|||GNE 390|||GDC-0980；RG 7422|||GNE 390|||GDC-0980
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal cell carcinoma, and endometrial carcinoma, among others.
价 格：￥电议型 号：T1916产 地：中国大陆
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T1806IDO-IN-7；化合物NLG919NLG919|||Navoximod|||NLG-919 analogue|||GDC-0919；NLG919|||Navoximod|||NLG-919 anal
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
价 格：￥电议型 号：T1806产 地：中国大陆
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T18053Ipatasertib-NH2；化合物 T18053RG7440-NH2|||GDC-0068-NH2；RG7440-NH2|||GDC-0068-NH2
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 to degrade AKT[1].
价 格：￥电议型 号：T18053产 地：中国大陆
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T15377Ravoxertinib hydrochloride化合物 T15377GDC-0994 (hydrochloride)
Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).
价 格：￥电议型 号：T15377产 地：中国大陆
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T15376GDC-0339；化合物GDC-0339GDC-0339
GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of the pan-Pim kinase (Kis: 0.03 nM, 0.1 nM, and 0.02 nM for Pim1, Pim2, and Pim3, respectively).
价 格：￥电议型 号：T15376产 地：中国大陆
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T15375Inavolisib；化合物 InavolisibGDC-0077|||RG6114；GDC-0077|||RG6114
Inavolisib (GDC-0077) is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
价 格：￥电议型 号：T15375产 地：中国大陆
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T15018CUDC-427；化合物CUDC-427GDC-0917；GDC-0917
CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.
价 格：￥电议型 号：T15018产 地：中国大陆
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T13700GDC-0927 Racemate；化合物 T13700SRN-927 Racemate；SRN-927 Racemate
GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.
价 格：￥电议型 号：T13700产 地：中国大陆
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T11399Giredestrant；化合物GiredestrantGDC-9545；GDC-9545
Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.
价 格：￥电议型 号：T11399产 地：中国大陆
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T11381Pictilisib dimethanesulfonate；化合物Pictilisib dimethanesulfonateGDC-0941 dimethanesulfonate|||GDC-0941
Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
价 格：￥电议型 号：T11381产 地：中国大陆
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T11380GDC-0927；化合物 T11380SRN-927；SRN-927
GDC-0927 is a novel,non-steroidal, potent, orally bioavailable, selective estrogen receptor antagonist.
价 格：￥电议型 号：T11380产 地：中国大陆
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T11379GDC-0834；化合物 T11379GDC-0834
GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse and rat, respectively. GDC-0834 is a potent and selective BTK inhib
价 格：￥电议型 号：T11379产 地：中国大陆
