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  • T75976Urotensin I TFA；化合物 Urotensin I TFAUrotensin I TFA

    Urotensin I (Catostomus urotensin I) TFA is a CRF-like neuropeptide that functions as an agonist for CRF receptors, demonstrating efficacy through pEC50 values of 11.46 for human CRF1, 9.36 for human CRF2, and 9.85 for rat CRF2α receptors in CHO cells. It also exhibits binding affinities (Ki) of 0.4 nM for hCRF1, 1.8 nM for rCRF2α, and 5.7 nM for mCRF2β receptors, respectively [1] [2].

    价 格：￥电议型 号：T75976产 地：中国大陆

  • T74976Antifungal agent 46；化合物 Antifungal agent 46Antifungal agent 46

    Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].

    价 格：￥电议型 号：T74976产 地：中国大陆

  • T73976Ivabradine impurity 2；化合物 Ivabradine impurity 2Ivabradine impurity 2

    Ivabradine Impurity 2, an impurity of Ivabradine, is a compound known for its oral bioavailability and mechanism as a blocker of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels [1].

    价 格：￥电议型 号：T73976产 地：中国大陆

  • T73903UNC4976 TFA；化合物 UNC4976 TFAUNC4976 TFA

    UNC4976 TFA, a positive allosteric modulator (PAM) peptidomimetic of the CBX7 chromodomain, promotes binding to nucleic acids. It concurrently inhibits the H3K27me3-specific recruitment of CBX7 to target genes and enhances non-specific interaction with DNA and RNA [1].

    价 格：￥电议型 号：T73903产 地：中国大陆

  • T7315BAY1125976；化合物BAY1125976BAY1125976

    BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)

    价 格：￥电议型 号：T7315产 地：中国大陆

  • T72976TGFβRI-IN-6；化合物 TGFβRI-IN-6TGFβRI-IN-6

    TGFβRI-IN-6 is a potent TGFβRI inhibitor with an IC50 value of 0.55 nM.TGFβRI-IN-6 has the potential to enhance anti-tumour immunity.

    价 格：￥电议型 号：T72976产 地：中国大陆

  • T72820(R)-Casopitant；化合物 (R)-Casopitant(R)-GW679769；(R)-GW679769

    (R)-Casopitant ((R)-GW679769), an isomer of Casopitant, functions as an NK(1)-receptor antagonist. It has applications in the study of chemotherapy-induced nausea and vomiting [1] [2].

    价 格：￥电议型 号：T72820产 地：中国大陆

  • T71976Fmoc-5-aminopentanoic acid；化合物 Fmoc-5-aminopentanoic acidFmoc-5-aminopentanoic acid

    Fmoc-5-aminopentanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

    价 格：￥电议型 号：T71976产 地：中国大陆

  • T7184Firsocostat；化合物ND-630ND-630|||NDI-010976|||GS-0976；ND-630|||NDI-010976|||GS-0976

    Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)

    价 格：￥电议型 号：T7184产 地：中国大陆

  • T70976AGN-190121；化合物 AGN-190121AGN-190121

    AGN-190121 is a retinoic acid receptor (RAR) agonist. RAR and Retinoid X Receptor (RXR) ligands can act synergistically to induce hypertriglyceridemia through distinct mechanisms of action.

    价 格：￥电议型 号：T70976产 地：中国大陆

  • T70171GSK1379767A；化合物 GSK1379767AGSK1379767A

    GSK1379767A is a dual inhibitor of BPTF and Brd4.

    价 格：￥电议型 号：T70171产 地：中国大陆

  • T69976WS-691；化合物 WS-691WS-691

    WS-691 is a highly Potent and Orally Active ABCB1 Modulator. WS-691 significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC50 = 22.02 nM). WS-691 significantly increased the intracellular concentration of PTX and [3H]-PTX while decreasing the efflux of [3H]- PTX in SW620/Ad300 cells by inhibiting the efflux function of ABCB1. WS-691 could stabilize ABCB1 by directly binding to ABCB1 WS-691 increased the sensitivity of SW620/Ad300 cells to PTX in vi

    价 格：￥电议型 号：T69976产 地：中国大陆

  • T69769BDP8900；化合物 BDP8900BDP8900

    BDP8900 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. BDP8900 leads to morphological changes in cancer cells along with inhibition of their motility and invasive character.

    价 格：￥电议型 号：T69769产 地：中国大陆

  • T69768WSD0922-FU；化合物 WSD0922-FUWSD0922-FU

    WSD0922-FU is a blood-brain-barrier (BBB) penetrable selective inhibitor of epidermal growth factor receptor (EGFR) and various EGFR mutations, including but not limited to the EGFR variant III (EGFRvIII) mutant form, with potential antineoplastic activity. WSD0922-FU is able to penetrate the BBB and specifically targets, binds to and inhibits EGFR and specific EGFR mutations, which prevents EGFR/EGFR mutant-mediated signaling and leads to cell death in EGFR/EGFR mutant-expressing tumor cells.

    价 格：￥电议型 号：T69768产 地：中国大陆

  • T69767NV-5440；化合物 NV-5440NV-5440

    NV-5440 is a novel cell penetrant, potent and selective class I glucose transporters (GLUT1) inhibitor, selectively inhibiting mTORC1

    价 格：￥电议型 号：T69767产 地：中国大陆

  • T69766Gusacitinib HCl；化合物 Gusacitinib HClGusacitinib HCl

    Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and

    价 格：￥电议型 号：T69766产 地：中国大陆

  • T69765NPD-039；化合物 NPD-039NPD-039

    NPD-039 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1).

    价 格：￥电议型 号：T69765产 地：中国大陆

  • T69764NPD-008；化合物 NPD-008NPD-008

    NPD-008 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1).

    价 格：￥电议型 号：T69764产 地：中国大陆

  • T697632C07；化合物 2C072C07

    2C07 is a Novel switch-II binder. 2C07 alters nucleotide preference and inhibits SOS binding and catalyzed nucleotide exchange.

    价 格：￥电议型 号：T69763产 地：中国大陆

  • T69762ZL0513；化合物 ZL0513ZL0513

    ZL0513 is a chromone derivatives used as orally bioavailable BRD4-selective inhibitor. This BRD4 BD1 inhibitor has demonstrated impressive in vivo efficacy and overall promising pharmacokinetic properties, indicating its therapeutic potential for the treatment of inflammatory diseases.

    价 格：￥电议型 号：T69762产 地：中国大陆

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