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  • T79667YCH1899；化合物 YCH1899YCH1899

    YCH1899, an orally active PARP inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM. It shows marked antiproliferative efficacy against Olaparib-resistant (Capan-1/OP) and Talazoparib-resistant (Capan-1/TP) cells with IC50 values of 0.89 nM and 1.13 nM, respectively. Moreover, YCH1899 possesses favorable pharmacokinetic attributes in rats [1].

    价 格：￥电议型 号：T79667产 地：中国大陆

  • T79158h15-LOX-2 inhibitor 1；化合物 h15-LOX-2 inhibitor 1h15-LOX-2 inhibitor 1

    Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].

    价 格：￥电议型 号：T79158产 地：中国大陆

  • T78814COH1；化合物 COH1COH1

    COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].

    价 格：￥电议型 号：T78814产 地：中国大陆

  • T78758IHMT-IDH1-053；化合物 IHMT-IDH1-053IHMT-IDH1-053

    IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-type and mutants. In 293T cells transfected with the IDH1 R132H mutant, IHMT-IDH1-053 reduces 2-hydroxyglutarate (2-HG) production with an IC50 value of 28 nM. The compound engages with the R132H protein at an allosteric site near the NAPDH binding region, forming a covalent link

    价 格：￥电议型 号：T78758产 地：中国大陆

  • T78681ITH12711；化合物 ITH12711ITH12711

    ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].

    价 格：￥电议型 号：T78681产 地：中国大陆

  • T78133UZH1b；化合物 UZH1bUZH1b

    UZH1b, an enantiomer of UZH1a (a METTL3 inhibitor), exhibits substantially reduced activity against METTL3, with an IC50 value of 28 ?M [1].

    价 格：￥电议型 号：T78133产 地：中国大陆

  • T7798FGH10019；化合物FGH-10019FGH-10019；FGH-10019

    FGH10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).

    价 格：￥电议型 号：T7798产 地：中国大陆

  • T77664KH16；化合物KH16KH16

    KH16 is a potent HDAC inhibitor that specifically targets class I HDACs (HDAC1, HDAC2 and HDAC3) with IC50 values between 6 and 34 nM. KH16 is able to stimulate apoptosis and can inhibit gene expression patterns in a wide range of tumor cells.

    价 格：￥电议型 号：T77664产 地：中国大陆

  • T77520AOH1996；化合物AOH1996AOH1996

    AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis.AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II.AOH1996 acts synergistically with DNA damaging agents to inhibit tumor ce

    价 格：￥电议型 号：T77520产 地：中国大陆

  • T77335PLH1215；化合物 PLH1215PLH1215

    PLH1215 is a compound that can be used to regulate, limit, or inhibit the expression of AVIL (advillin), which can be used to treat cancer.

    价 格：￥电议型 号：T77335产 地：中国大陆

  • T76381H1-7 (histone H1 phosphorylation site), PKA Substrate；化合物 H1-7 (histone H1 phosphorylation site), PK

    H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].

    价 格：￥电议型 号：T76381产 地：中国大陆

  • T7552H-1152化合物H-1152H1152|||ROCK|||H-1152

    H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).

    价 格：￥电议型 号：T7552产 地：中国大陆

  • T72705IDH1 Inhibitor 7；化合物 IDH1 Inhibitor 7IDH1 Inhibitor 7

    IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC 50 of less than 100 nM [1] .

    价 格：￥电议型 号：T72705产 地：中国大陆

  • T72057H1k；化合物H1kH1k

    H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1.

    价 格：￥电议型 号：T72057产 地：中国大陆

  • T71270ZEL-H16；化合物 ZEL-H16ZEL-H16

    ZEL-H16 is an agonist of the histamine H3 receptor.

    价 格：￥电议型 号：T71270产 地：中国大陆

  • T70903KRH102053；化合物 KRH102053KRH102053

    KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells.

    价 格：￥电议型 号：T70903产 地：中国大陆

  • T70352PH11；化合物 PH11PH11

    PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL

    价 格：￥电议型 号：T70352产 地：中国大陆

  • T70121Zavondemstat；化合物 ZavondemstatQC8222|||TACH 101|||TACH101；QC8222|||TACH 101|||TACH101

    Zavondemstat, a compound exhibiting antineoplastic activity, functions as an inhibitor of the histone lysine demethylase 4D (KDM4D).

    价 格：￥电议型 号：T70121产 地：中国大陆

  • T68511KRH102140；化合物 KRH102140KRH102140

    KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube format

    价 格：￥电议型 号：T68511产 地：中国大陆

  • T67864TH1760化合物TH1760MKB

    TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine.

    价 格：￥电议型 号：T67864产 地：中国大陆

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