TN1828KahweolInhibitor,inhibit,Kahweol,AMPK,Apoptosis,AMP-activated protein kinase

Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity.

价 格：￥电议型 号：TN1828产 地：中国大陆

T9702EclitasertibSAR-443122,RIPK,Receptor-interacting protein kinases,SAR443122,DNL 758,DNL758,Eclitasert

Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 ?Μ).

价 格：￥电议型 号：T9702产 地：中国大陆

T8427BorussertibBorussertib,Inhibitor,PKB,Akt,Protein kinase B,inhibit

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)

价 格：￥电议型 号：T8427产 地：中国大陆

T6643Ro 31-8220 Mesylateinhibit,Inhibitor,Ro 318220 Mesylate,Protein kinase C,PKC,Ro 31 8220 Mesylate,Ro

Ro 31-8220 is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.

价 格：￥电议型 号：T6643产 地：中国大陆

T7362O-304O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304

O-304 is a pan-activator of AMP-activated protein kinase (AMPK).

价 格：￥电议型 号：T7362产 地：中国大陆

T9611PF-04802367PF367,PF 367,protein,disease,Alzheimer,PF-04802367,PF-367,Glycogen synthase kinase-3,kina

PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and potency. It is equally effective at inhibition of the two known GSK-3 isoforms (GSK-3α and GSK-3β) with IC50 values of 10.0 and 9.0 nM in mobility shift assays, respectively.

价 格：￥电议型 号：T9611产 地：中国大陆

T6938PF-4989216Apoptosis,inhibit,Phosphoinositide 3-kinase,PF4989216,PF-4989216,PI3K,Inhibitor

PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.

价 格：￥电议型 号：T6938产 地：中国大陆

T6948Pluripotininhibit,Extracellular signal regulated kinases,Ribosomal S6 Kinase (RSK),SC-1,SC 1,Inhibit

Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.

价 格：￥电议型 号：T6948产 地：中国大陆

T6409ALK kinase inhibitor-1kinase,ALK tyrosine kinase receptor,Anaplastic lymphoma kinase,lymphoma,Anapla

价 格：￥电议型 号：T6409产 地：中国大陆

TQ0055AMG-3969Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit

AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).

价 格：￥电议型 号：TQ0055产 地：中国大陆

TN1134Euscaphic acidEuscaphic acid,Inhibitor,PI3K,inhibit,Apoptosis,Phosphoinositide 3-kinase,DNA/RNA Synt

Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations.

价 格：￥电议型 号：TN1134产 地：中国大陆

TN1405Arnicolide DMammalian target of Rapamycin,Phosphoinositide 3-kinase,inhibit,Inhibitor,Caspase,mTOR,A

Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.

价 格：￥电议型 号：TN1405产 地：中国大陆

T7390DMATinhibit,Casein Kinase,DMAT,Inhibitor

DMAT is a potent and specific inhibitor of CK2(IC50 value of 130 nM).

价 格：￥电议型 号：T7390产 地：中国大陆

T8399Crizotinib hydrochlorideCD246,PF-02341066,ROS Kinase,Autophagy,ALK tyrosine kinase receptor,Anaplast

Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)

价 格：￥电议型 号：T8399产 地：中国大陆

T9576AMP-945Focal adhesion kinase,Inhibitor,PTK2 protein tyrosine kinase 2,inhibit,AMP945,PTK2,AMP-945,AM

AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.

价 格：￥电议型 号：T9576产 地：中国大陆

TN1557Decursinol angelateProtein kinase C,inhibit,Inhibitor,Decursinol angelate,PKC

Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity.

价 格：￥电议型 号：TN1557产 地：中国大陆

T12069MK-8353SCH 900353,Extracellular signal regulated kinases,Inhibitor,inhibit,MK 8353,SCH-900353,MK-835

MK-8353 is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)

价 格：￥电议型 号：T12069产 地：中国大陆

T63581-AzakenpaulloneGlycogen synthase kinase-3,1 Azakenpaullone,GSK-3,1-Azakenpaullone,1Azakenpaullone,G

1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.

价 格：￥电议型 号：T6358产 地：中国大陆

T8850sbp-7455SBP-7455,ULK,TNBC,ULK2,ULK1,Unc-51 like kinase,sbp7455,Ser318,sbp 7455,Inhibitor,inhibit,Aut

SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.

价 格：￥电议型 号：T8850产 地：中国大陆

T6760APS-2-79 hydrochlorideMAP2K,MAPKK,Inhibitor,Mitogen-activated protein kinase kinase,APS 2 79 hydroch

APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK.

价 格：￥电议型 号：T6760产 地：中国大陆