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T74571TSPO Ligand-Linker Conjugates 1;化合物 TSPO Ligand-Linker Conjugates 1TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1, comprising a translocator protein (TSPO) ligand and a linker, is instrumental in synthesizing mitochondria-targeting autophagy-targeting chimera (AUTAC). This compound binds TSPO on the outer mitochondrial membrane (OMM), facilitating the degradation of malfunctioning mitochondria and proteins through mitophagy, thereby enhancing mitochondrial function. It holds potential applications in research related to mitochondrial dysfunction, encompassing neurodegenerativ
价 格:¥电议型 号:T74571产 地:中国大陆
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T74492CD22 ligand-1;化合物 CD22 ligand-1CD22 ligand-1
CD22 Ligand-1 (Compound 12) is a potent, selective ligand for CD22, exhibiting dissociation constants (K_D) of 0.335 ?M for human CD22 (hCD22) and 30.7 ?M for myelin-associated glycoprotein (MAG), indicating specificity towards hCD22. This ligand holds potential for B-cell related disease research [1].
价 格:¥电议型 号:T74492产 地:中国大陆
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T74399Heterobivalent ligand-1;化合物 Heterobivalent ligand-1Heterobivalent ligand-1
Heterobivalent ligand-1 (compound 26) serves as a heterobivalent ligand targeting the Adenosine A 2A-dopamine D 2 receptor heteromer, exhibiting binding affinities of K DB1 A 2A R=2.1 nM and K DB1 D 2 R= 0.13 nM [1].
价 格:¥电议型 号:T74399产 地:中国大陆
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T74173PROTAC PARP/EGFR ligand 1;化合物 PROTAC PARP/EGFR ligand 1PROTAC PARP/EGFR ligand 1
PROTAC PARP/EGFR ligand 1 is a potent compound utilized in the creation of dual PARP-EGFR degraders through Proteolytic Targeting Chimera (PROTAC) technology [1].
价 格:¥电议型 号:T74173产 地:中国大陆
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T74137PROTAC Bcl-xL ligand-1;化合物 PROTAC Bcl-xL ligand-1PROTAC Bcl-xL ligand-1
PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].
价 格:¥电议型 号:T74137产 地:中国大陆
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T73941PROTAC BCR-ABL1 ligand 1;化合物 PROTAC BCR-ABL1 ligand 1PROTAC BCR-ABL1 ligand 1
GMB-475, also known as PROTAC BCR-ABL1 ligand 1, allosterically targets and binds to the BCR-ABL1 protein. It effectively recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and subsequent degradation of BCR-ABL1 [1].
价 格:¥电议型 号:T73941产 地:中国大陆
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T73599TSPO ligand-1;TSPO配体1TSPO ligand-1
TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.TSPO ligand-1 is an AUTAC4-binding protein in the transmembrane domain of the outer mitochondrial membrane, which induces mitochondrial autophagy and promotes intracellular mitochondrial regeneration.TSPO ligand-1 is involved in intracellular cholesterol transport, and can be used as a biomarker for brain injury and neurodegeneration. TSPO ligand-1 is involved in intracellular cholesterol transport and can be used as
价 格:¥电议型 号:T73599产 地:中国大陆
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T72018MAO-B ligand-1;化合物 MAO-B ligand-1MAO-B ligand-1
MAO-B ligand-1 is a selective MAO-B inhibitor.
价 格:¥电议型 号:T72018产 地:中国大陆
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T72013Epigenetic Multiple Ligand;化合物 Epigenetic Multiple LigandEpigenetic Multiple Ligand
Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation.
价 格:¥电议型 号:T72013产 地:中国大陆
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T63799GID4 Ligand 1;化合物 GID4 Ligand 1GID4 Ligand 1
GID4 Ligand 1 is a cell-permeable, highly selective GID4 binder with an IC50 value of 5.4 μM and a Kd value of 5.6 μM. GID4 Ligand 1 is capable of binding GID4 in cells with an EC50 value of 558 nM. GID4 Ligand 1 is capable of being used in the synthesis of PROTACs.
价 格:¥电议型 号:T63799产 地:中国大陆
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T63048Sigma-LIGAND-1 hydrochloride;化合物 Sigma-LIGAND-1 hydrochlorideSigma-LIGAND-1 hydrochloride
Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand that acts at the DTG (IC50: 16 nM) and PPP (IC50: 19 nM) sites. Sigma-LIGAND-1 hydrochloride is able to act on the dopamine D2 receptor (Ki: 4000 nM).
价 格:¥电议型 号:T63048产 地:中国大陆
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T62870FABPs ligand 6;化合物 FABPs ligand 6FABPs ligand 6
FABPs ligand 6 (MF6) is an inhibitor of FABP5 (Kd: 874 nM) and FABP7 (Kd: 20 nM), which can be used in the study of multiple sclerosis.
价 格:¥电议型 号:T62870产 地:中国大陆
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T62528Dopamine D3 receptor ligand-1;化合物 Dopamine D3?receptor ligand-1Dopamine D3 receptor ligand-1
Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki: 715 nM).
价 格:¥电议型 号:T62528产 地:中国大陆
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T62141RBP4 ligand-1;化合物 RBP4 ligand-1RBP4 ligand-1
RBP4 ligand-1 is a non-retinoid ligand for retinol-binding protein 4 (RBP4). hRBP4SPAIC50 and RBP4-TTR FRET IC50 values were 0.23±0.11 and 0.13±0.12 μM for the radioligand binding assay and FRET assay, respectively. 0.12 μM.
价 格:¥电议型 号:T62141产 地:中国大陆
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T61825EED ligand 1;化合物 EED ligand 1EED ligand 1
EED ligand 1 is a highly versatile, potent, and effective inhibitor that specifically targets the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase.
价 格:¥电议型 号:T61825产 地:中国大陆
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T615155-HT7 receptor ligand 1;化合物 5-HT7 receptor ligand 15-HT7 receptor ligand 1
5-HT7 receptor ligand 1 (Compound 5c) is a potent ligand for the 5-HT7 receptor, with a K i value of 8 nM. The compound demonstrates non-hepatotoxic properties and displays moderate potential for drug-drug interactions with substrates of CYP3A4 or CYP2D6 enzymes [1].
价 格:¥电议型 号:T61515产 地:中国大陆
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T612205-HT6/5-HT2A receptor ligand-2;化合物 5-HT6/5-HT2A receptor ligand-25-HT6/5-HT2A receptor ligand-2
Compound 42, a 5-HT6/5-HT2A receptor ligand-2, serves as a dual antagonist for the 5-HT6 and 5-HT2A receptors with Ki values of 25 nM and 32 nM, respectively. This brain-penetrant compound exhibits pro-cognitive properties [1].
价 格:¥电议型 号:T61220产 地:中国大陆
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T612075-HT6/5-HT2A receptor ligand-1;化合物 5-HT6/5-HT2A receptor ligand-15-HT6/5-HT2A receptor ligand-1
5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual antagonist for the 5-HT6 and 5-HT2A receptors. It exhibits a K i value of 2 nM and 11 nM for the respective receptors. This compound holds promise for research in neurological and psychiatric disorders [1].
价 格:¥电议型 号:T61207产 地:中国大陆
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T60728M1 ligand 1;化合物 M1 ligand 1M1 ligand 1
M1 ligand 1 (compound 3b-b) is a N-desmethyl congener of arecoline derivative that is a muscarinic acetylcholine receptor M1 ligand. M1 ligand 1 is able to be used as PET (positron emission tomography) radiotracer [1].
价 格:¥电议型 号:T60728产 地:中国大陆
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T60722Prohibitin ligand 1;化合物 Prohibitin ligand 1Prohibitin ligand 1
Prohibitin ligand 1 (Compound 22i) is a cardioprotectant prohibitin ligand that exhibits in vitro cardioprotectant activities at nanomolar concentrations. Prohibitin ligand 1 induces the pro-survival factor STAT3 phosphorylation [1].
价 格:¥电议型 号:T60722产 地:中国大陆