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T18872(S,R,S)-AHPC-PEG5-COOH；化合物 T18872VH032-PEG5-COOH|||E3 Ligase Ligand-Linker Conjugates 58|||VHL Ligan
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthetic E3 ligase ligand-linker conjugate developed for use in PROTAC technology. It consists of the (S,R,S)-AHPC based VHL ligand and a 5-unit PEG linker [1].
价 格：￥电议型 号：T18872产 地：中国大陆
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T18826Thalidomide-O-PEG2-propargyl；化合物 T18826E3 ligase Ligand-Linker Conjugates 32；E3 ligase Ligand-Linker
Thalidomide-O-PEG2-propargyl (E3 Ligase Ligand-Linker Conjugates 32) is a chemical compound that has been synthesized as a conjugate of an E3 ligase ligand and a linker. It incorporates the cereblon ligand based on Thalidomide, along with a 2-unit PEG linker. This compound is specifically designed for use in PROTAC technology, which utilizes ligand-induced protein degradation [1].
价 格：￥电议型 号：T18826产 地：中国大陆
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T18650Ch55-O-C3-NH2；化合物 T18650RAR ligand 1；RAR ligand 1
Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR. Through a linker, Ch55-O-C3-NH2 interacts with cIAP1 ligand Bestatin to form SNIPER[1].
价 格：￥电议型 号：T18650产 地：中国大陆
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T18602VH032-thiol-C6-NH2；化合物 T18602VHL Ligand-Linker Conjugates 14|||E3 ligase Ligand-Linker Conjugates 29
VH032-thiol-C6-NH2, also known as VHL Ligand-Linker Conjugates 14, is a synthesized compound that functions as an E3 ligase ligand-linker conjugate. This compound combines the VH032 based VHL ligand with a linker commonly utilized in PROTAC technology.
价 格：￥电议型 号：T18602产 地：中国大陆
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T18600VH032 thiol；化合物 T18600VHL ligand 6；VHL ligand 6
VH032 thiol (VHL ligand 6) is a VHL ligand that interacts with pan-BET inhibitor JQ1 through a linker to create a PROTAC[1] compound.
价 格：￥电议型 号：T18600产 地：中国大陆
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T18555Pomalidomide-PEG2-Tos；化合物 T18555Cereblon Ligand-Linker Conjugates 16|||E3 ligase Ligand-Linker Conju
Pomalidomide-PEG2-Tos is a compound that consists of an E3 ligase ligand-linker conjugate. It is composed of a cereblon ligand conjugated to a two-unit PEG linker[1].
价 格：￥电议型 号：T18555产 地：中国大陆
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T18553Pomalidomide-amido-PEG3-C2-NH2；化合物 T18553Cereblon Ligand-Linker Conjugates 22|||E3 ligase Ligand-Lin
Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]
价 格：￥电议型 号：T18553产 地：中国大陆
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T18515Palbociclib-propargyl；化合物 T18515PROTAC CDK6 ligand 1；PROTAC CDK6 ligand 1
Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].
价 格：￥电议型 号：T18515产 地：中国大陆
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T18063Lenalidomide-acetylene-C5-COOH；化合物 T18063Cereblon ligand-linker Conjugate；Cereblon ligand-linker Con
Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) serves as a Lenalidomide-based Cereblon ligand that facilitates the recruitment of the CRBN protein. This compound can be connected to the protein´s ligand through a linker, resulting in the formation of PROTAC[1].
价 格：￥电议型 号：T18063产 地：中国大陆
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T18059K-Ras ligand-Linker Conjugate 6；化合物 T18059K-Ras ligand-Linker Conjugate 6
K-Ras ligand-Linker Conjugate 6 is a chemical compound that combines a ligand for K-Ras recruiting moiety and a PROTAC linker. This compound can recruit E3 ligases, including VHL, CRBN, MDM2, and IAP. K-Ras ligand-Linker Conjugate 6 is particularly useful in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].
价 格：￥电议型 号：T18059产 地：中国大陆
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T18058K-Ras ligand-Linker Conjugate 5；化合物 T18058K-Ras ligand-Linker Conjugate 5
K-Ras ligand-Linker Conjugate 5 is a chemical compound that combines a ligand for the K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The K-Ras ligand-Linker Conjugate 5 plays a crucial role in the synthesis of PROTAC K-Ras Degrader-1, a highly potent K-Ras degrader. In SW1573 cells, this degrader exhibits an impressive degradation efficacy of ≥70% [1].
价 格：￥电议型 号：T18058产 地：中国大陆
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T18057K-Ras ligand-Linker Conjugate 4；化合物 T18057K-Ras ligand-Linker Conjugate 4
K-Ras ligand-Linker Conjugate 4 is a chemical compound that combines a ligand for K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The compound has the potential to be used in the synthesis of PROTAC K-Ras Degrader-1, a powerful degrader of K-Ras that has been shown to exhibit a degradation efficacy of ≥70% in SW1573 cells[1].
价 格：￥电议型 号：T18057产 地：中国大陆
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T18056K-Ras ligand-Linker Conjugate 3；化合物 T18056K-Ras ligand-Linker Conjugate 3
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].
价 格：￥电议型 号：T18056产 地：中国大陆
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T18055K-Ras ligand-Linker Conjugate 2；化合物 T18055K-Ras ligand-Linker Conjugate 2
K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
价 格：￥电议型 号：T18055产 地：中国大陆
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T18054K-Ras ligand-Linker Conjugate 1；化合物 T18054K-Ras ligand-Linker Conjugate 1
K-Ras ligand-Linker Conjugate 1 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, facilitating the recruitment of E3 ligases VHL, CRBN, MDM2, and IAP. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].
价 格：￥电议型 号：T18054产 地：中国大陆
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T17943FAK ligand-Linker Conjugate 1；化合物 T17943FAK ligand-Linker Conjugate 1
FAK ligand-Linker Conjugate 1 is a chemical compound designed to facilitate PROTAC-mediated protein degradation. This compound consists of a ligand specifically targeting FAK and a PROTAC linker module, which acts as a recruitment agent for E3 ligases including VHL, CRBN, MDM2, and IAP[1].
价 格：￥电议型 号：T17943产 地：中国大陆
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T17941ERRα Ligand-Linker Conjugates 1；化合物 T17941ERRα Ligand-Linker Conjugates 1
ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds utility in the synthesis of a range of PROTACs, including one known as PROTAC ERRalpha Degrader-1. With its capability to induce degradation of ERRα, PROTAC ERRalpha Degrader-1 functions as an ERRα degrader[1].
价 格：￥电议型 号：T17941产 地：中国大陆
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T17940Estrone-N-O-C1-amido；化合物 T17940ERα ligand 1；ERα ligand 1
Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 ligand Bestatin, leading to the creation of SNIPER[1].
价 格：￥电议型 号：T17940产 地：中国大陆
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T17928Lenalidomide-C5-NH2；化合物 T17928E3 ligase Ligand-Linker Conjugates 31|||Cereblon Ligand-Linker Conjuga
Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].
价 格：￥电议型 号：T17928产 地：中国大陆
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T17927(S,R,S)-AHPC TFA；化合物(S,R,S)-AHPC TFAVH032-NH2 TFA|||VHL ligand 1 TFA；VH032-NH2 TFA|||VHL ligand 1 TF
(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to create PROTACs (e.g., GMB-475), which effectively induce the degradation of BCR-ABL1, demonstrated by an IC50 of 1.11 μM in Ba/F3 cells.
价 格：￥电议型 号：T17927产 地：中国大陆
