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  • T70862AMPK Activator SC4；化合物 AMPK Activator SC4AMPK Activator SC4

    SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.

    价 格：￥电议型 号：T70862产 地：中国大陆

  • T67925Nampt activator-1；化合物Nampt activator-1Nampt activator-1

    NAMPT Activator-1 (compound 1) is an effective and specific activator of niacinamide phosphotransferase (Compound 1) with a wide range of EC50 (3.3-3.7 μM). NAMPT activator-1 effectively protects cultured cells from FK866-mediated toxicity and is a potential neuroprotective compound.

    价 格：￥电议型 号：T67925产 地：中国大陆

  • T67858STIMA-1；2-乙烯基-3H-4-喹唑啉酮2-Vinylquinazolin-4-ol|||p53 Activator VII；2-Vinylquinazolin-4-ol|||p53 Activ

    STIMA-1 (2-Vinylquinazolin-4-ol), an active compound, can restore the activity of p63. STIMA-1 can stimulate the proliferation and differentiation of keratinocytes.

    价 格：￥电议型 号：T67858产 地：中国大陆

  • T63844PKG1α activator 3；化合物 PKG1α activator 3PKG1α activator 3

    PKG1α activator 3 is a PKG1α activator (EC50basal/partial=13/0.52 μM). PKG1α activator 3 is able to inhibit the proliferation of smooth muscle cells and can be used to study cardiovascular diseases.

    价 格：￥电议型 号：T63844产 地：中国大陆

  • T63672RyRs activator 2；化合物 RyRs activator 2RyRs activator 2

    RyRs activator 2 is a potent activator of ranibulin receptors (RyRs). ryRs activator 2 has a larvicidal activity of 30%, which is comparable to chlorfenvinphos (30%) and better than cyanobenzamide (10%).

    价 格：￥电议型 号：T63672产 地：中国大陆

  • T63665EIF2α activator 1；化合物 EIF2α activator 1EIF2α activator 1

    EIF2α Activator 1 (Compound 40) is a chemical compound that activates the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α), enhancing the expression of downstream proteins ATF and CHOP. It demonstrates antiproliferative effects against K562 and PBMC cells, with IC50 values of 4.00 and 19.3 μM, respectively [1].

    价 格：￥电议型 号：T63665产 地：中国大陆

  • T63474RyRs activator 1；化合物 RyRs activator 1RyRs activator 1

    RyRs activator 1 is a potent activator of ranibulin receptors (RyRs).RyRs activator 1 has 100% larvicidal activity at 0.5 mg/L and 90% larvicidal activity at 0.01 mg/L.

    价 格：￥电议型 号：T63474产 地：中国大陆

  • T63364Nrf2 activator-5；化合物 Nrf2 activator-5Nrf2 activator-5

    Nrf2 activator-5 is a potent activator of Nrf2 that attenuates H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglia, exhibiting antioxidant and anti-inflammatory activity.

    价 格：￥电议型 号：T63364产 地：中国大陆

  • T6332120S Proteasome activator 1；20S蛋白酶激动剂120S Proteasome activator 1

    20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation of pathogenic alpha-synuclein A53T mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. The 20S Proteasome activator 1 can be used to study neurodegenerative diseases.

    价 格：￥电议型 号：T63321产 地：中国大陆

  • T63177AMPK activator 8；化合物 AMPK activator 8AMPK activator 8

    AMPK activator 8 (Compound 2) is an AMP-activated protein kinase (AMPK) activator that acts on rAMPK α1β1γ1 (EC50: 11 nM), rAMPK α2β1γ1 (EC50: 27 nM), rAMPK α1β2γ1 (EC50: 4 nM), rAMPK α2β2 AMPK activator 8 can be used to study type 2 diabetes.

    价 格：￥电议型 号：T63177产 地：中国大陆

  • T63117AMPK activator 7；化合物 AMPK activator 7AMPK activator 7

    AMPK activator 7 (compound I-3-24) is an AMPK activator (EC50: 8.8 nM). AMPK activator 7 can be used in studies involving AMPK disorders, particularly type 2 diabetes, hyperglycaemia, metabolic syndrome, obesity, hypercholesterolaemia and/or hypertension.

    价 格：￥电议型 号：T63117产 地：中国大陆

  • T63016Nrf2 activator-4；Nrf2 激活剂4Nrf2 activator-4

    Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.

    价 格：￥电议型 号：T63016产 地：中国大陆

  • T62758PKM2 activator 2；PKM2激活剂2PKM2 activator 2

    PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabolism through activation of PKM2.

    价 格：￥电议型 号：T62758产 地：中国大陆

  • T62637EIF2α activator 2；化合物 EIF2α activator 2EIF2α activator 2

    EIF2α activator 2 (Compound 1) is a phosphorylated activator of eukaryotic initiation factor 2α (eIF2α). EIF2α activator 2 is anti-proliferative in K562 cells (IC50: 4.79 μM) and PBMC cells (IC50: 10.52 μM).

    价 格：￥电议型 号：T62637产 地：中国大陆

  • T62238AMPK activator 4；化合物AMPK activator 4AMPK activator 4

    AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels and improves insulin resistance in db/db diabetic mice.AMPK activator 4 has hypoglycemic effects. activator 4 has hypoglycemic effects.

    价 格：￥电议型 号：T62238产 地：中国大陆

  • T62052AMPK activator 6；化合物 AMPK activator 6AMPK activator 6

    AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (LDL-C), triglyceride (TG), and other biochemical indices in blood serum. AMPK activator 6 has research value in non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome .

    价 格：￥电议型 号：T62052产 地：中国大陆

  • T61992SIK1 activator 1；化合物 SIK1 activator 1SIK1 activator 1

    SIK1 activator 1 can enhances the SIK1 phosphorylation and ameliorated the hyperglyceamia of type 2 diabetic mice. SIK1 activator 1 exhibited remarkable inhibitory activity on hepatic gluconeogenesis.

    价 格：￥电议型 号：T61992产 地：中国大陆

  • T61688Nrf2 activator-2；化合物 Nrf2 activator-2Nrf2 activator-2

    Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces the ubiquitination of Nrf2 in cells, indicating its potential in regulating Nrf2 activity [1].

    价 格：￥电议型 号：T61688产 地：中国大陆

  • T61522Nrf2/HO-1 activator 2；化合物 Nrf2/HO-1 activator 2Nrf2/HO-1 activator 2

    Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway through phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. This compound finds utility in the investigation of Parkinson´s disease (PD) [1].

    价 格：￥电议型 号：T61522产 地：中国大陆

  • T61504PKM2 activator 3；化合物 PKM2 activator 3PKM2 activator 3

    PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is particularly valuable for anticancer research purposes [1]. (AC 50: the concentration at which 50% enzyme activation occurs.)

    价 格：￥电议型 号：T61504产 地：中国大陆

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