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T67745CB2R/FAAHu00A0modulator-2；化合物CB2R/FAAHu00A0modulator-2CB2R/FAAHu00A0modulator-2
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki values are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 has studies research value related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
价 格：￥电议型 号：T67745产 地：中国大陆
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T6657SB273005；化合物SB273005SB273005
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
价 格：￥电议型 号：T6657产 地：中国大陆
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T6655SB-269970 hydrochloride化合物SB269970 HClSB-269970A|||SB269970 HCl
SB-269970 hydrochloride (SB-269970A) , a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
价 格：￥电议型 号：T6655产 地：中国大陆
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T62631CB2 receptor antagonist 1；化合物 CB2 receptor antagonist 1CB2 receptor antagonist 1
Hexyl resorcinol derivative 29 is a CB2 selective competitive antagonist/reverse agonist demonstrating notable potency. Meanwhile, Olivanol and 5-(2-methyloctane-2-yl) resorcinol derivatives 23 and 24 exhibit substantial antinociceptive effects. Notably, compound 24 activates both cannabinoid and TRPV1 receptors.
价 格：￥电议型 号：T62631产 地：中国大陆
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T6103VS-5584；化合物VS5584SB2343|||VS 5584|||VS5584；SB2343|||VS 5584|||VS5584
VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.
价 格：￥电议型 号：T6103产 地：中国大陆
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T5360Eprotirome；伊罗替罗KB2115；伊罗替罗|||KB2115
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
价 格：￥电议型 号：T5360产 地：中国大陆
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T4674SB297006；化合物SB 297006SB 297006；SB 297006
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).
价 格：￥电议型 号：T4674产 地：中国大陆
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T4260Capmatinib 2HCl；INCB28060盐酸盐INC-280 2HCl|||INCB28060 2HCl；INC-280 2HCl|||INCB28060盐酸盐|||INCB28060 2H
Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation a
价 格：￥电议型 号：T4260产 地：中国大陆
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T41246Thromboxane B2；化合物 Thromboxane B2Thromboxane B2
Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces platelet aggregation and arterial contraction.
价 格：￥电议型 号：T41246产 地：中国大陆
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T4078SB 242235化合物SB242235SB-242235|||SB242235
SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.
价 格：￥电议型 号：T4078产 地：中国大陆
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T3919Ginsenoside Rb2；人参皂苷 Rb2Ginsenoside C；Ginsenoside C|||人参皂苷 Rb2|||人参皂苷Rb2
Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.
价 格：￥电议型 号：T3919产 地：中国大陆
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T39176PB28；PB28PB28
PB28 is a cyclohexylpiperazine derivative that functions as a potent and highly selective agonist of the sigma 2 (σ2) receptor, exhibiting a Ki (binding affinity) of 0.68 nM. At the same time, PB28 acts as an antagonist of the sigma 1 (σ1) receptor, with a Ki of 0.38 nM. PB28 demonstrates a lower affinity for other receptors. It effectively inhibits electrically evoked twitch in both the guinea pig bladder (EC50 value of 2.62 μM) and ileum (EC50 value of 3.96 μM). Moreover, PB28 exhibits the abi
价 格：￥电议型 号：T39176产 地：中国大陆
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T38778DB2115 tertahydrochloride；DB2115 tertahydrochlorideDB2115 tertahydrochloride；DB2115 tertahydrochlori
DB2115 (tertahydrochloride) is a powerful inhibitor of the myeloid master regulator PU.1. With significant potential in cancer research, particularly hematologic cancers like leukemia, as well as other conditions linked to PU.1 dysfunction, DB2115 (tertahydrochloride) offers promising avenues of study.
价 格：￥电议型 号：T38778产 地：中国大陆
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T38384Nexinhib20Nexinhib20Nexinhib-20|||Nexinhib20
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflamma
价 格：￥电议型 号：T38384产 地：中国大陆
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T3810Saikosaponin B2柴胡皂苷 B2柴胡皂苷 B2|||柴胡皂甙 B2
Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with potentiation of expressions of tyrosinase and melanogenesis.
价 格：￥电议型 号：T3810产 地：中国大陆
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T37173Bofutrelvir；福布特韦DC-402234|||MPro Inhibitor 11a|||FB2001；DC-402234|||MPro Inhibitor 11a|||FB2001
Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.
价 格：￥电议型 号：T37173产 地：中国大陆
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T37075CB2R PAM；化合物CB2R PAMEc2la；Ec2la
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors, but has no effect in the absence of agonists. ...CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.
价 格：￥电议型 号：T37075产 地：中国大陆
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T36543Prostaglandin B2；Prostaglandin B2PGB2；PGB2
Prostaglandin B2 (PGB2) is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 ug/kg). [1]
价 格：￥电议型 号：T36543产 地：中国大陆
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T35889PB2；PB2PB2
PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1].
价 格：￥电议型 号：T35889产 地：中国大陆
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T35771Destruxin B2；Destruxin B2Destruxin B2
Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3
价 格：￥电议型 号：T35771产 地：中国大陆
