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T73239DC-BPi-11;化合物 DC-BPi-11DC-BPi-11
DC-BPi-11, a potent inhibitor of the bromodomain PHD finger transcription factor (BPTF), exhibits significant anti-proliferative effects against leukemia cells with an IC50 value of 698 nM.
价 格:¥电议型 号:T73239产 地:中国大陆
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T72399LIMK1 inhibitor BMS-4;化合物 LIMK1 inhibitor BMS-4LIMK1 inhibitor BMS-4
LIMK1 inhibitor BMS-4 is a compound targeting LIM Kinase (LIMK) 1/2, specifically inhibiting the phosphorylation of its substrate, cofilin, but it remains noncytotoxic on A549 cells.
价 格:¥电议型 号:T72399产 地:中国大陆
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T72397PARP11 inhibitor ITK7;化合物 PARP11 inhibitor ITK7ITK7;ITK7
PARP11 Inhibitor ITK7 (ITK7) is a potent, selective inhibitor of PARP11, demonstrating significant efficacy with an IC50 value of 14 nM. It is primarily utilized in research focused on cellular localization.
价 格:¥电议型 号:T72397产 地:中国大陆
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T72396Antimalarial agent 20;化合物 Antimalarial agent 20Antimalarial agent 20
Antimalarial agent 20, exhibiting potent efficacy with an IC50 value of 0.6 nM against the P. falciparum NF54 parasite strain within the NF54 albumax assay, serves as a significant antimalarial compound.
价 格:¥电议型 号:T72396产 地:中国大陆
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T72395CB1 inverse agonist 2;化合物 CB1 inverse agonist 2CB1 inverse agonist 2
CB1 Inverse Agonist 2, an orally active compound, serves as an inverse agonist for the Cannabinoid Receptor CB1. It effectively counteracts the hypothermia and anorexia induced by CP55940 in mouse models.
价 格:¥电议型 号:T72395产 地:中国大陆
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T72394KRAS G12D inhibitor 3;化合物 KRAS G12D inhibitor 3KRAS G12D inhibitor 3
KRAS G12D Inhibitor 3, a compound targeting the KRAS G12D mutation, demonstrates potent antitumor efficacy with an inhibitory concentration (IC50) of less than 500 nM.
价 格:¥电议型 号:T72394产 地:中国大陆
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T72393Crozbaciclib fumarate;化合物 Crozbaciclib fumarateCrozbaciclib fumarate
Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.
价 格:¥电议型 号:T72393产 地:中国大陆
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T72392E7766 diammonium salt;化合物 E7766 diammonium saltE7766 diammonium salt
E7766 diammonium salt, a macrocycle-bridged STING agonist, exhibits a dissociation constant (Kd) of 40 nM, demonstrating potent pan-genotypic and antitumor activities.
价 格:¥电议型 号:T72392产 地:中国大陆
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T72391Clocortolone pivalate;化合物 Clocortolone pivalateClocortolone pivalate
Clocortolone pivalate, a synthetic glucocorticoid corticosteroid and corticosteroid ester, is used to treat seborrheic dermatitis, contact dermatitis, atopic dermatitis, and psoriasis.
价 格:¥电议型 号:T72391产 地:中国大陆
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T72390Estradiol hemihydrate;化合物 Estradiol hemihydrate17β-Oestradiol hemihydrate|||β-Estradiol hemihydrate
Estradiol (β-Estradiol) hemihydrate, a key female sex hormone and steroid, plays a significant role in up-regulating neural markers in human endometrial stem cells (hEnSCs) and facilitating their neural differentiation. It is also utilized in research focused on cancers, neurodegenerative diseases, and neural tissue engineering.
价 格:¥电议型 号:T72390产 地:中国大陆
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T72239DDO-2093 dihydrochloride;化合物 DDO-2093 dihydrochlorideDDO-2093 dihydrochloride
DDO-2093 dihydrochloride, a potent inhibitor of MLL1-WDR5 protein-protein interactions (IC50=8.6 nM; Kd=11.6 nM), exhibits antitumor activity. It selectively inhibits the catalytic activity of the MLL complex.
价 格:¥电议型 号:T72239产 地:中国大陆
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T71715CU239;化合物 CU239CU239
CU239 is a selective non-retinoid inhibitor of RPE65 which suppresses visual cycle and prevents retinal degeneration.
价 格:¥电议型 号:T71715产 地:中国大陆
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T71353CCT239065;化合物 CCT239065CCT239065
CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor.
价 格:¥电议型 号:T71353产 地:中国大陆
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T71239CNV-2197944;化合物 CNV-2197944CNV-2197944
CNV-2197944 is a novel, small molecule, state-dependent calcium channel blocker, designed to selectively inhibit highly active Cav2.2 channels.
价 格:¥电议型 号:T71239产 地:中国大陆
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T70865BMY-42393;化合物 BMY-42393BMY-42393
BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 microM). BMY-42393 stimulated platelet adenylate cyclase activity (EC50 = 25 nM). Platelets treated with BMY 42393 showed an elevation of cAMP levels and activation of cAMP-dependent protein kinase. BMY 42393 also inhibited thrombin-induced elevation of intracellular free calcium. B
价 格:¥电议型 号:T70865产 地:中国大陆
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T70345JAS239;化合物 JAS239JAS239
JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways. In mice bearing orthotopic MCF7 breast xenografts, optical imaging with JAS239 distinguished tumors overexpressing C
价 格:¥电议型 号:T70345产 地:中国大陆
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T70239CP-64434 hydrate;化合物 CP-64434 hydrateCP-64434 hydrate
CP-64434 hydrate is an antibiotic; anti-proliferative HDAC inhibitor.
价 格:¥电议型 号:T70239产 地:中国大陆
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T70111GT-2394;化合物 GT-2394GT-2394
GT-2394 is a histamine H3 receptor agonist.
价 格:¥电议型 号:T70111产 地:中国大陆
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T6S2391L-Chicoric Acid;L-菊苣酸(-)-Chicoric acid|||trans-Caffeoyltartaric acid|||Chicoric acid|||dicaffeoyltar
L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. 3. L-Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condens
价 格:¥电议型 号:T6S2391产 地:中国大陆
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T69830GSK2239633;化合物 GSK2239633GSK2239633
GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy.
价 格:¥电议型 号:T69830产 地:中国大陆