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T76301Agouti-related Protein (AGRP) (83-132) Amide (human)；化合物 Agouti-related Protein (AGRP) (83-132) Amid
Agouti-related Protein (AGRP) (83-132) Amide (human) is a segment derived from the agouti-related protein (AGRP), abundantly present in the hypothalamus´ arcuate nucleus. It predominantly functions as an inverse agonist for the melanocortin-4 receptor (MC4R), thereby promoting food intake [1] [2].
价 格：￥电议型 号：T76301产 地：中国大陆
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T75301(R)-Dinotefuran；化合物 (R)-Dinotefuran(R)-Dinotefuran
(R)-Dinotefuran ((R)-MTI-446), a neonicotinoid pesticide, demonstrates insecticidal activities 1.7-2.4 times more effective against typical sucking pests like Aphis gossypii and Apolygus lucorum when compared to its racemic mixtures, by targeting nicotinic acetylcholine receptors. Additionally, (R)-Dinotefuran is effective in managing these pests while posing a reduced risk to honeybees [1].
价 格：￥电议型 号：T75301产 地：中国大陆
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T74301PSI-353661；化合物 PSI-353661PSI-353661
PSI-353661 (GS-558093), a purine nucleotide NS5B polymerase inhibitor, is effective against HCV infection, displaying EC90 values of 8 nM and 11 nM for wild-type and S282T resistant HCV replicons, respectively. It is capable of generating high concentrations of the active triphosphate form in primary human hepatocytes [1] [3].
价 格：￥电议型 号：T74301产 地：中国大陆
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T73458LWG-301；化合物 LWG-301LWG-301
LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing apoptosis. Additionally, LWG-301 shows moderate antitumor efficacy in the HCT116 xenograft model.
价 格：￥电议型 号：T73458产 地：中国大陆
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T73346SC 34301；化合物 SC 34301Enisoprost；Enisoprost
SC 34301 (Enisoprost), a potent and orally active prostaglandin E1 (PGE1) analog, significantly enhances survival rates and reduces bacterial translocation in burned mice.
价 格：￥电议型 号：T73346产 地：中国大陆
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T73301ATR-IN-20；化合物 ATR-IN-20ATR-IN-20
ATR-IN-20, a potent ATM/ATR inhibitor, showcases an IC50 value of 3 nM. It also exhibits inhibitory activity against mTOR with an IC50 of 18 nM, while maintaining selectivity over PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM). Additionally, ATR-IN-20 has an excellent pharmacokinetic profile with an oral bioavailability (F) of 30%, and demonstrates anticancer effects.
价 格：￥电议型 号：T73301产 地：中国大陆
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T73156LabMol-301；化合物 LabMol-301LabMol-301
LabMol-301, a chemical compound, effectively inhibits NS5 RdRp and NS2B-NS3pro activity with IC50 values of 0.8 μM and 7.4 μM, respectively. Additionally, it exhibits cytoprotective effects, safeguarding against Zika virus (ZIKV)-induced cell death.
价 格：￥电议型 号：T73156产 地：中国大陆
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T73019MALT1-IN-11；化合物 MALT1-IN-11MALT1-IN-11
MALT1-IN-11, a potent MALT1 protease inhibitor (IC 50 < 10 nM), effectively reduces IL10 secretion, exhibiting an IC 50 between 10-100 nM. This compound is primarily utilized in the study of cancer, autoimmune, and inflammatory disorders.
价 格：￥电议型 号：T73019产 地：中国大陆
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T73018NLRP3-IN-13；化合物 NLRP3-IN-13NLRP3-IN-13
NLRP3-IN-13 is a selective and potent inhibitor of NLRP3 (IC 50: 2.1 μM), capable of inhibiting both NLRP3 and NLRC4 inflammasomes as well as NLRP3-mediated IL-1β production. Furthermore, NLRP3-IN-13 suppresses NLRP3 ATPase activity. This compound is utilized in research focused on neuroinflammatory disorders.
价 格：￥电议型 号：T73018产 地：中国大陆
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T73017ONO-0740556；化合物 ONO-0740556ONO-0740556
ONO-0740556 is a potent agonist of the Gi-coupled human lysophosphatidic acid receptor 1 (LPA1), exhibiting an EC50 value of 0.26 nM.
价 格：￥电议型 号：T73017产 地：中国大陆
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T73016THRX-144644；化合物 THRX-144644THRX-144644
THRX-144644, a lung-restricted ALK5 inhibitor, exhibits a potent IC50 value of 0.14 nM and circumvents systemic toxicities linked to TGFβ pathway inhibition.
价 格：￥电议型 号：T73016产 地：中国大陆
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T73015NLRP3-IN-16；化合物 NLRP3-IN-16NLRP3-IN-16
NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1].
价 格：￥电议型 号：T73015产 地：中国大陆
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T73014NLRP3-IN-15；化合物 NLRP3-IN-15NLRP3-IN-15
NLRP3-IN-15 is a potent, selective inhibitor of the NLRP3 inflammasome, demonstrating efficacy by inhibiting IL-1β (interleukin-1 beta) release with an IC50 value of 0.114 μM. This compound is utilized in the research of inflammation.
价 格：￥电议型 号：T73014产 地：中国大陆
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T73013NLRP3-IN-14；化合物 NLRP3-IN-14NLRP3-IN-14
NLRP3-IN-14 is a potent, selective inhibitor of the NLRP3 inflammasome, displaying a dissociation constant (K D) of 5.87 μM and an IC50 of 0.131 μM for inhibiting IL-1β release. It is applicable for inflammation research.
价 格：￥电议型 号：T73013产 地：中国大陆
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T73011HSP90-IN-20；化合物 HSP90-IN-20HSP90-IN-20
HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.
价 格：￥电议型 号：T73011产 地：中国大陆
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T7301BDP5290；化合物BDP5290BDP5290
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
价 格：￥电议型 号：T7301产 地：中国大陆
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T71606RO5073012；化合物 RO5073012RO5073012
RO5073012 is a novel potent and selective TAAR1 partial agonist.
价 格：￥电议型 号：T71606产 地：中国大陆
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T71415FPL-63012AR；化合物 FPL-63012ARFPL-63012AR
FPL-63012AR is a D1-receptor agonist.
价 格：￥电议型 号：T71415产 地：中国大陆
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T71301Opaganib HCl；化合物 Opaganib HClOpaganib HCl
ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis a
价 格：￥电议型 号：T71301产 地：中国大陆
