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  • T63014Ivabradine；化合物 IvabradineIvabradine

    Ivabradine is a potent, orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits pacemaker current (If). ivabradine decreases heart rate in a dose-dependent manner and does not alter blood pressure. ivabradine has anticonvulsant, anti-ischaemic and anti-anginal effects.

    价 格：￥电议型 号：T63014产 地：中国大陆

  • T63013Ruboxistaurin；化合物 RuboxistaurinRuboxistaurin

    Ruboxistaurin (LY333531) is a selective, orally active PKC beta inhibitor with a Ki value of 2 nM. Ruboxistaurin competitively inhibits PKC beta I (IC50: 4.7 nM) in an ATP-dependent manner. Ruboxistaurin is able to act on PKC beta II (IC50: 5.9 nM).

    价 格：￥电议型 号：T63013产 地：中国大陆

  • T63012TM-1；化合物 TM-1TM-1

    TM-1 is a potent pyruvate dehydrogenase kinase (PDHK) inhibitor that inhibits the activity of PDHK1 (IC50: 2.97 μM) and PDHK2 (IC50: 5.2 μM). TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation and inhibits cancer cell proliferation.

    价 格：￥电议型 号：T63012产 地：中国大陆

  • T63011Henatinib；化合物 HenatinibHenatinib

    Henatinib is an orally active small molecule multi-kinase inhibitor with broad antitumour effects. henatinib inhibits the activity of VEGFR-2 (IC50: 0.6 nM), c-kit (IC50: 3.3 nM), PDGFR (IC50: 41.5 nM). henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signalling pathways in human umbilical vein endothelial cells (HUVECs). Henatinib significantly inhibited VEGFR-2 phosphorylation and its downstream signaling pathway in human umbilical vein endothelial cells (HUVECs).

    价 格：￥电议型 号：T63011产 地：中国大陆

  • T63010ZXH-1-161；化合物 ZXH-1-161ZXH-1-161

    ZXH-1-161 is a potent regulator of cereblon (CRBN) that acts on wild-type MM1.S cells (IC50: 39 μM). ZXH-1-161 selectively degrades GSPT1. ZXH-1-161 can be used to study multiple myeloma.

    价 格：￥电议型 号：T63010产 地：中国大陆

  • T6301Tosedostat；托舍多特CHR-2797；CHR-2797|||托舍多特

    Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases, particularly puromycin-sensitive aminopeptidase (PuSA), and leukotriene A4 (LTA4) hydrolase; inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation, inhibition of protein synthesis

    价 格：￥电议型 号：T6301产 地：中国大陆

  • T62301J-1063；化合物 J-1063J-1063

    J-1063 is a selective, orally active and potent inhibitor of ALK5 (IC50: 0.039 μM). J-1063 inhibits inflammatory infiltration, collagen deposition, hepatocyte necrosis and exhibits anti-fibrotic effects. j-1063 has potential for liver fibrosis studies.

    价 格：￥电议型 号：T62301产 地：中国大陆

  • T62149ALM301；化合物 ALM301ALM301

    ALM301 is a highly specific, orally active AKT inhibitor that acts on AKT1 (IC50: 0.13 μM), AKT2 (IC50: 0.09 μM) and AKT3 (IC50: 2.75 μM). ALM301 inhibits AKT phosphorylation in vitro and has a regulatory effect on downstream signalling. ALM301 exhibits inhibitory effects on cancer cell proliferation and tumor growth.

    价 格：￥电议型 号：T62149产 地：中国大陆

  • T61301Chromenone 1；化合物Chromenone 1Chromenone 1

    Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.

    价 格：￥电议型 号：T61301产 地：中国大陆

  • T60661CP681301；化合物 CP681301CP681301

    CP681301 is a potent inhibitor of CDK5 with antiproliferative activity. CP681301 exhibits anti-tumor activity in Drosophila. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in Glioma stem cells (GSCs). CP681301 reduces self-renewal in mouse glioma xenografts [1].

    价 格：￥电议型 号：T60661产 地：中国大陆

  • T60301(Z)-p-cyano-α-Cyanostilbene；化合物 (Z)-p-cyano-α-Cyanostilbene(Z)-p-cyano-α-Cyanostilbene

    (Z)-p-cyano-α-Cyanostilbene (compound 11) is a phenantrene derivative that has antiproliferative activity. (Z)-p-cyano-α-Cyanostilbene shows significant selectivity against HeLa (IC 50 =0.21 μM) and HepG2 (IC 50 =0.230 μM) cells without cytotoxic against normal skin fibroblasts (IC 50 >100 μM) [1].

    价 格：￥电议型 号：T60301产 地：中国大陆

  • T60166WAY-301207；化合物WAY-301207WAY-301207

    WAY-301207 is a Biochemical.

    价 格：￥电议型 号：T60166产 地：中国大陆

  • T6006Romidepsin；罗米地辛FR 901228|||FK 228|||Depsipeptide|||NSC 630176；FR 901228|||FK 228|||Depsipeptide|||罗米

    Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1/2/4/6 (IC50=36/47/510/1400 nM). Romidepsin has antitumor activity and can be used for the treatment of peripheral T-cell lymphoma and cutaneous T-cell lymphoma.

    价 格：￥电议型 号：T6006产 地：中国大陆

  • T5394Prulifloxacin；普卢利沙星AF 3012|||Pruvel|||NM441；AF 3012|||Pruvel|||NM441|||普卢利沙星

    Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II and IV.

    价 格：￥电议型 号：T5394产 地：中国大陆

  • T500301-(2,4-difluorophenyl)guanidine hydrochloride；化合物T500301-(2,4-difluorophenyl)guanidine hydrochloride

    1-(2,4-difluorophenyl)guanidine hydrochloride is a compound that is a potent and selective inhibitor of the voltage-gated sodium channel Nav1.7, a key player in pain signaling. It is therefore able to reduce pain signaling, resulting in an analgesic effect.

    价 格：￥电议型 号：T50030产 地：中国大陆

  • T4301AD80；化合物AD80AD80

    AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.

    价 格：￥电议型 号：T4301产 地：中国大陆

  • T4285Crisaborole；克立硼罗AN-2728|||PF-06930164；克立硼罗|||AN-2728|||PF-06930164

    Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.

    价 格：￥电议型 号：T4285产 地：中国大陆

  • T41301L-Cysteinesulfinic acid monohydrate；L-半胱氨酸亚磺酸一水合物L-Cysteinesulfinic acid monohydrate

    L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

    价 格：￥电议型 号：T41301产 地：中国大陆

  • T40301Antibacterial agent 28；Antibacterial agent 28Antibacterial agent 28

    Antibacterial agent 28, with a minimum inhibitory concentration (MIC) range of 0.5-2 μg/mL, exhibits promising potential as an antibacterial candidate targeting MRSA infections.

    价 格：￥电议型 号：T40301产 地：中国大陆

  • T38301Click N-Acetylmuramic acid - alkyne；Click N-Acetylmuramic acid - alkyneClick N-Acetylmuramic acid -

    Derivative of N-acetylmuramic acid (NAM) component of bacterial peptidoglycans. Incorporated into bacterial peptidoglycans during biosynthesis. Suitable for fluorescent labeling of peptidoglycans when ´click´-conjugated to a fluorescent dye.

    价 格：￥电议型 号：T38301产 地：中国大陆

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