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T80269AC3-I, myristoylated;化合物 AC3-I, myristoylatedAutocamtide-3 Derived Inhibitory Peptide;Autocamtide-3
Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I). It acts as a highly specific inhibitor of Calmodulin-Dependent Protein Kinase II (CaMKII) with enhanced resistance to proteolysis. This compound is a derivative of Autocamtide-3, where the Thr-9 phosphorylation site is replaced by Ala.
价 格:¥电议型 号:T80269产 地:中国大陆
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T80264C34 peptide;化合物 C34 peptideC34 peptide
C34 peptide, also referred to as HR2, is a biologically active peptide integral to the helical region of HIV´s gp41 and is specifically the C-terminal heptad repeat 2 (HR2), denoted as the C helix or C peptide. It functions as a potent inhibitor of HIV-1 fusion, thereby impeding the virus´s entry into cells via membrane fusion.
价 格:¥电议型 号:T80264产 地:中国大陆
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T79912NSC309401;化合物 NSC309401NSC309401
NSC309401 is an E. coli dihydrofolate reductase inhibitor, displaying potency with an IC50 value of 189 nM and a dissociation constant (KD) of 14.57 nM [1].
价 格:¥电议型 号:T79912产 地:中国大陆
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T79714HDAC3-IN-2;化合物 HDAC3-IN-2HDAC3-IN-2
HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells. Demonstrating cytotoxic activity, HDAC3-IN-2 exhibits an IC50 of 0.55 μM against 4T1 cells and 0.74 μM against MDA-MB-231 cells. In vivo, it shows anti-tumor efficacy in tumor-bearing mouse models by selectively elevating acetylation of histones H3K9, H3K27, and H4K12, enhancing apoptosis-inducing proteins caspase-3, caspase-7, and cytochrome c, an
价 格:¥电议型 号:T79714产 地:中国大陆
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T79555G43-C3-TEG;化合物 G43-C3-TEGG43-C3-TEG
G43-C3-TEG is a glycosyl-transferase inhibitor that diminishes biofilm formation by inhibiting the synthesis of extracellular polysaccharides (EPS) [1].
价 格:¥电议型 号:T79555产 地:中国大陆
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T79433AKR1C3-IN-10;化合物 AKR1C3-IN-10AKR1C3-IN-10
AKR1C3-IN-10 (compound 5r), a selective inhibitor of AKR1C3 with an IC50 of 51 nM, demonstrates efficacy in a prostate cancer xenograft model [1].
价 格:¥电议型 号:T79433产 地:中国大陆
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T79255UPCDC30766;化合物 UPCDC30766UPCDC30766
UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].
价 格:¥电议型 号:T79255产 地:中国大陆
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T79054TRPC3/6-IN-2;化合物 TRPC3/6-IN-2TRPC3/6-IN-2
TRPC3/6-IN-2 is a potent inhibitor of TRPC3 and TRPC6, exhibiting IC50 values of 16 nM for TRPC3 and 29.8 nM for TRPC6, respectively [1].
价 格:¥电议型 号:T79054产 地:中国大陆
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T78821IHC3;化合物 IHC3IHC3
IHC3 is a competitive and reversible monoamine oxidase B (MAO-B) inhibitor with an IC50 of 1.672 μM, which targets Cys172 within the enzyme´s active site. It is utilized in the study of neurological diseases [1].
价 格:¥电议型 号:T78821产 地:中国大陆
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T78413ETZ;化合物 ETZC3-CA-DTZ;C3-CA-DTZ
ETZ (C3-CA-DTZ) represents a promising luciferase substrate (prosubstrate) that, upon activation by nonspecific esterase in vivo, facilitates enhanced delivery of luciferin to the brain [1].
价 格:¥电议型 号:T78413产 地:中国大陆
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T77950Thalidomide-5-O-C3-NH2 hydrochloride;化合物 Thalidomide-5-O-C3-NH2 hydrochlorideThalidomide-5-O-C3-NH2
Thalidomide-5-O-C3-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates CRBN protein recruitment and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1].
价 格:¥电议型 号:T77950产 地:中国大陆
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T7760Thalidomide-O-amido-C3-NH2 TFA;化合物Thalidomide-O-amido-C3-NH2 TFACereblon Ligand-Linker Conjugates 16
Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-C3-NH2 TFA incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
价 格:¥电议型 号:T7760产 地:中国大陆
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T77440Codrituzumab;考曲妥珠单抗RG-7686|||RO5137382|||GC33;RG-7686|||RO5137382|||GC33
Codrituzumab (GC3) is a humanized antibody against the glypican-3 hepatocellular carcinoma protein that can be used in combination with sorafenib to study incurable advanced hepatocellular carcinoma (HCC).
价 格:¥电议型 号:T77440产 地:中国大陆
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T76668FC382K10W15 TFA;化合物 FC382K10W15 TFAFC382K10W15 TFA
FC382K10W15 TFA, a glucagon analogue and GLP-1R/GCGR agonist, holds promise for research in type 2 diabetes [1].
价 格:¥电议型 号:T76668产 地:中国大陆
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T76565PDC31;化合物 PDC31PDC31
PDC31 (THG113.31; ILGHXDYK) is a D-amino acid-based oligopeptide that acts as an allosteric and non-competitive inhibitor of the FP Prostaglandin Receptor, used primarily as a smooth muscle contractile agent. It effectively reduces the strength and duration of uterine contractions in vivo, offering potential for preterm labor and primary dysmenorrhea (PD) research. Additionally, PDC31 enhances the Ca2+-dependent large-conductance K+-channel in human myometrial cells [1] [2].
价 格:¥电议型 号:T76565产 地:中国大陆
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T7642Cilostamide;OPC 3689 西洛酰胺OPC3689;OPC3689|||OPC 3689 西洛酰胺
Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)
价 格:¥电议型 号:T7642产 地:中国大陆
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T75966C3a (70-77) (TFA);化合物 C3a (70-77) (TFA)C3a (70-77) (TFA)
Complement 3a (70-77) TFA is an octapeptide that corresponds to the COOH terminus of C3a and exhibits the specificity and 1 to 2% biological activities of C3a [1] [2].
价 格:¥电议型 号:T75966产 地:中国大陆
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T75850JKC363 TFA;化合物 JKC363 TFAJKC363 TFA
JKC363 TFA is a selective melanocortin MC4 receptor antagonist that exhibits a 90-fold higher affinity for the MC4 receptor (IC50=0.5 nM) compared to the MC3 receptor (44.9 nM). This compound effectively inhibits the α-MSH-induced stimulation of TRH release. It also demonstrates an anti-hyperalgesic effect [1] [2].
价 格:¥电议型 号:T75850产 地:中国大陆
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T75466Palmarumycin C3;化合物 Palmarumycin C3Palmarumycin C3
Palmarumycin C3, a spirobisnaphthalene compound, is derived from the endophytic fungus Berkleasmium sp. Dzf12 following 1-hexadecene treatment. It demonstrates significant antimicrobial and antioxidant activities.
价 格:¥电议型 号:T75466产 地:中国大陆
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T7497L1C3a 70-77 acetate;化合物C3a 70-77 acetateC3a 70-77 acetate (63555-63-5 Free base);C3a 70-77 acetate (63
C3a 70-77 acetate is the octapeptide acetate corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
价 格:¥电议型 号:T7497L1产 地:中国大陆