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  • T72924VEGFR-3-IN-1；VEGFR-3抑制剂1VEGFR-3-IN-1

    VEGFR-3-IN-1 is a novel potent and selective VEGFR3 inhibitor with an IC50 of 110.4 nM.VEGFR-3-IN-1 possesses antitumor activity, inactivates the VEGFR3 signaling pathway, and inhibits the proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231 and MDA-MB-436 cells. MB-436 cells and inhibited the proliferation and migration of human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231 and MDA-MB-436 cells.

    价 格：￥电议型 号：T72924产 地：中国大陆

  • T72890VEGFR-2-IN-30；化合物 VEGFR-2-IN-30VEGFR-2-IN-30

    VEGFR-2-IN-30, a compound acting primarily as a VEGFR-2 inhibitor (IC50: 66 nM), demonstrates additional inhibitory effects on PDGFR, EGFR, and FGFR1, with IC50 values of 180, 98, and 82 nM, respectively. It effectively arrests cancer cells in the S-phase and induces both early and late apoptosis.

    价 格：￥电议型 号：T72890产 地：中国大陆

  • T72854EGFR/HER2-IN-9；化合物 EGFR/HER2-IN-9EGFR/HER2-IN-9

    EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR T790M mutation.

    价 格：￥电议型 号：T72854产 地：中国大陆

  • T72844EGFR/CDK2-IN-1；化合物 EGFR/CDK2-IN-1EGFR/CDK2-IN-1

    EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application in cancer research.

    价 格：￥电议型 号：T72844产 地：中国大陆

  • T72788EGFR/C797S-IN-1；化合物 EGFR/C797S-IN-1EGFR/C797S-IN-1

    EGFR/C797S-IN-1 is a potent inhibitor targeting the EGFR-C797S mutation, demonstrated by its IC 50 value of 0.128 ?M. This compound exhibits significant anti-proliferative and anti-tumor effects by inhibiting p-EGFR expression in a dose-dependent manner.

    价 格：￥电议型 号：T72788产 地：中国大陆

  • T72713PI3K/VEGFR2-IN-1；化合物 PI3K/VEGFR2-IN-1PI3K/VEGFR2-IN-1

    PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively. This compound also induces apoptosis and is utilized in cancer research [1].

    价 格：￥电议型 号：T72713产 地：中国大陆

  • T72608VEGFR-2/BRAF-IN-2；化合物 VEGFR-2/BRAF-IN-2VEGFR-2/BRAF-IN-2

    VEGFR-2/BRAF-IN-2, as a dual VEGFR-2 and BRAF kinase inhibitor, exhibits potent IC50 values of 0.111 ?M, 0.089 ?M, and 0.071 ?M against VEGFR-2, BRAF V600E, and BRAF WT, respectively. This compound effectively induces apoptosis and predominantly arrests the cell cycle in the G1 phase.

    价 格：￥电议型 号：T72608产 地：中国大陆

  • T72607VEGFR-2/BRAF-IN-1；化合物 VEGFR-2/BRAF-IN-1VEGFR-2/BRAF-IN-1

    VEGFR-2/BRAF-IN-1, a dual inhibitor of VEGFR-2 and BRAF kinases, demonstrates potent inhibitory activity with IC50 values of 0.049 ?M for VEGFR-2, 0.063 ?M for BRAF V600E, and 0.005 ?M for BRAF WT. It effectively induces apoptosis and arrests the cell cycle primarily at the G1/S phase.

    价 格：￥电议型 号：T72607产 地：中国大陆

  • T70324EGFR-IN-557；化合物 EGFR-IN-557EGFR-IN-557

    EGFR-IN-557 is an EGFR inhibitor, attenuating Ang II-induced Kidney Fibrosis.

    价 格：￥电议型 号：T70324产 地：中国大陆

  • T69807EGFR-IN-451；化合物 EGFR-IN-451EGFR-IN-451

    EGFR-IN-451 is an EGFR inhibitor, attenuating Ang II-induced Kidney Fibrosis.

    价 格：￥电议型 号：T69807产 地：中国大陆

  • T68526VEGFR-IN-V；化合物 VEGFR-IN-VVEGFR-IN-V

    VEGFR-IN-V is a potent, vascular endothelial growth factor receptor-?2 (VEGFR-2) tyrosine kinase inhibitor.

    价 格：￥电议型 号：T68526产 地：中国大陆

  • T64255EGFR-IN-48；化合物 EGFR-IN-48EGFR-IN-48

    EGFR-IN-48 is a potent, orally active EGFR inhibitor that acts on EGFRd19/TM/CS (IC50: 0.193 nM), EGFRLR/TM/CS (IC50: 0.251 nM), EGFRWT (IC50: 10.4 nM). EGFR-IN-48 is also able to inhibit EGFR-IN-48 also inhibits the proliferation of BaF3EGFR del19/T790M/C797S cells (IC50: 1.526 nM) and PC-9EGFR del19/T790M/C797S cells (IC50: 66.7 nM).

    价 格：￥电议型 号：T64255产 地：中国大陆

  • T64254EGFR/HER2-IN-5；化合物 EGFR/HER2-IN-5EGFR/HER2-IN-5

    EGFR/HER2-IN-5 is an irreversible, orally active dual inhibitor of EGFR activity (IC50: 0.6 nM). EGFR/HER2-IN-4 shows potent EGFR kinase inhibitory activity against L858R and T790M mutations. EGFR/HER2-IN-4 exhibits significant anti-tumour effects in vivo and can be used to study lung cancer.

    价 格：￥电议型 号：T64254产 地：中国大陆

  • T64253EGFR/HER2-IN-4；化合物 EGFR/HER2-IN-4EGFR/HER2-IN-4

    EGFR/HER2-IN-4 is an irreversible, orally active dual inhibitor of EGFR activity (IC50: 0.6 nM). EGFR/HER2-IN-4 shows potent EGFR kinase inhibitory activity against L858R and T790M mutations. EGFR/HER2-IN-4 exhibits significant anti-tumour effects in vivo and can be used to study lung cancer.

    价 格：￥电议型 号：T64253产 地：中国大陆

  • T64170EGFR-IN-18；化合物 EGFR-IN-18EGFR-IN-18

    EGFR-IN-18 is a potent inhibitor of the enzymatic activity of the L858R/T790M/C797S mutant EGFR (4.9 nM) and is also able to reduce the enzymatic activity of wild-type EGFR (47 nM).

    价 格：￥电议型 号：T64170产 地：中国大陆

  • T64030EGFR-IN-31；化合物 EGFR-IN-31EGFR-IN-31

    EGFR-IN-31 is a potent inhibitor of EGFR. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been shown to cause uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-31 exhibits research potential for EGFR mutation-related diseases.

    价 格：￥电议型 号：T64030产 地：中国大陆

  • T64020EGFR-IN-17；化合物 EGFR-IN-17EGFR-IN-17

    EGFR-IN-17 is a potent and selective epidermal growth factor receptor (EGFR) inhibitor with an IC50 value of 0.0002 μM and can be used to overcome C797S-mediated drug resistance.

    价 格：￥电议型 号：T64020产 地：中国大陆

  • T63996EGFR-IN-50；化合物 EGFR-IN-50EGFR-IN-50

    EGFR-IN-50 is a potent EGFR inhibitor targeting L858R resistance mutations, acting on TEL-EGFR-L858R-BaF3 and TEL-EGFR-T790M-L858R-BaF3 with GI50 values of 8 nM and 6.03 μM, respectively. EGFR-IN-50 exhibits anti-proliferative effects on cancer cells. .

    价 格：￥电议型 号：T63996产 地：中国大陆

  • T63900VEGFR-2-IN-11；化合物 VEGFR-2-IN-11VEGFR-2-IN-11

    VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.

    价 格：￥电议型 号：T63900产 地：中国大陆

  • T63895EGFR-IN-62；化合物 EGFR-IN-62EGFR-IN-62

    EGFR-IN-62 is a potent inhibitor of EGFR kinase with IC50 values of 10 nM for L858R/T790 M, 29 nM for WT and 2 42 nM for L858R/T790 M/C797S. EGFR-IN-62 blocks the cell cycle of A549 and/or H1975 cells in G1/G0 phase and induces apoptosis and motility inhibition. EGFR-IN-62 effectively inhibited the proliferation of A549 (IC50: 2.53 μM) and H1975 cells (IC50: 1.56 μM).

    价 格：￥电议型 号：T63895产 地：中国大陆

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