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  • T81126SORT-PGRN interaction inhibitor 2；化合物 SORT-PGRN interaction inhibitor 2SORT-PGRN interaction inhibit

    SORT-PGRN Interaction Inhibitor 2 is a compound that downregulates SORT1 protein expression and enhances extracellular progranulin (PGRN) secretion in various mammalian cell lines, and is utilized in the study of neurological diseases [1].

    价 格：￥电议型 号：T81126产 地：中国大陆

  • T81104SREBP/SCAP-IN-2；化合物 SREBP/SCAP-IN-2SREBP/SCAP-IN-2

    SREBP/SCAP-IN-2 (compound 13) acts as a selective inhibitor of SREBP/SCAP [1].

    价 格：￥电议型 号：T81104产 地：中国大陆

  • T8109d-Neomenthol；(1S,2S,5R)-(+)-新薄荷醇(1S,2S,5R)-2-Isopropyl-5-Methylcyclohexanol|||(+)-Neomenthol；(1S,2S,

    d-Neomenthol ((+)-Neomenthol) is a natural product.

    价 格：￥电议型 号：T8109产 地：中国大陆

  • T81075SUCNR1-IN-2；化合物 SUCNR1-IN-2SUCNR1-IN-2

    SUCNR1-IN-2 (Statement 35) serves as an inhibitor of both succinate and succinate receptor 1, utilized in research pertaining to neurodegenerative disorders, including neuroinflammation [1].

    价 格：￥电议型 号：T81075产 地：中国大陆

  • T81060Sulfo-SPDB-DGN462；化合物 Sulfo-SPDB-DGN462Sulfo-SPDB-DGN462

    Sulfo-SPDB-DGN462 is an agent-linker conjugate utilized for Antibody-Drug Conjugates (ADCs), featuring the potent DNA-alkylating agent DGN462 known for its anti-tumor properties, including efficacy against acute myeloid leukemia (AML), and is conjugated via the cleavable Sulfo-SPDB linker.

    价 格：￥电议型 号：T81060产 地：中国大陆

  • T81059SWELYYPLRANL-NH2；化合物 SWELYYPLRANL-NH2SWELYYPLRANL-NH2

    SWELYYPLRANL-NH2 is a dual antagonist of E-cadherin and N-cadherin, effectively inhibiting the binding of phage clones to both E-cad/Fc and N-cad/Fc chimeric proteins with IC50 values of 0.7 μM and 0.09 μM, respectively. This compound also impedes cell aggregation and has potential applications in enhancing drug delivery by increasing epithelial and endothelial permeability barriers [1].

    价 格：￥电议型 号：T81059产 地：中国大陆

  • T80234SFNGGP-NH2；化合物 SFNGGP-NH2SFNGGP-NH2

    SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor. Human cutaneous mast cells express PAR-3 mRNA, implicating a role in itch mechanotransduction, with both histamine-dependent and independent pathways reported. While PAR-3 alone does not induce itch, it may potentiate itch when co-expressed with PAR-4, enhancing thrombin´s action. This suggests that PAR-3´s primary function is not as a signal trans

    价 格：￥电议型 号：T80234产 地：中国大陆

  • T80168Scorpion toxin Tf2；化合物 Scorpion toxin Tf2Scorpion toxin Tf2

    Scorpion toxin Tf2, a β-scorpion toxin first identified in the venom of the Brazilian scorpion Tityus fasciolatus, acts as an activator of the neuronal voltage-gated sodium (Nav) subtype Nav1.3, associated with epilepsy and nociception. It increases hNav1.3 activation voltage, prompting channel opening at resting membrane potentials [1].

    价 格：￥电议型 号：T80168产 地：中国大陆

  • T79601SPC-180002；化合物 SPC-180002SPC-180002

    SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively. It disrupts redox homeostasis through ROS generation, consequently enhancing p21 protein stability and inducing mitochondrial dysfunction. Furthermore, this compound significantly impedes cell cycle progression and malignancy proliferation, while also activating the Nrf2 signaling pathway [1].

    价 格：￥电议型 号：T79601产 地：中国大陆

  • T7959(+)-ISOPINOCAMPHEOL；(1S,2S,3S,5R)-(+)-异松蒎醇(+)-ISOPINOCAMPHEOL

    (+)-ISOPINOCAMPHEOL is a natural product.

    价 格：￥电议型 号：T7959产 地：中国大陆

  • T79563Sirt1/2-IN-2；化合物 Sirt1/2-IN-2Sirt1/2-IN-2

    Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines [1].

    价 格：￥电议型 号：T79563产 地：中国大陆

  • T79185STAT6-IN-2；化合物 STAT6-IN-2STAT6-IN-2

    STAT6-IN-2 (Comp R-84) serves as a STAT6 inhibitor, effectively reducing the secretion of the chemokine eotaxin-3, which is known to induce eosinophil infiltration. This compound is useful in the study of immune diseases [1].

    价 格：￥电议型 号：T79185产 地：中国大陆

  • T79013SLMP53-2；化合物 SLMP53-2SLMP53-2

    SLMP53-2 is a mutant p53 reactivator that restores the wild-type-like conformation and DNA-binding ability of mutp53-Y220C through enhanced interaction with Hsp70, thereby reinstating p53´s transcriptional activity. This compound induces cell cycle arrest, apoptosis, and endoplasmic reticulum (ER) stress, displaying antitumor activity [1] [2].

    价 格：￥电议型 号：T79013产 地：中国大陆

  • T78983STAT3 degrader-2；化合物 STAT3 degrader-2STAT3 degrader-2

    STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1].

    价 格：￥电议型 号：T78983产 地：中国大陆

  • T78926SARS-CoV-2-IN-42；化合物 SARS-CoV-2-IN-42SARS-CoV-2-IN-42

    SARS-CoV-2-IN-42 (Compound 8q) effectively inhibits SARS-CoV-2 replication with an EC50 value of 0.4 μM and demonstrates no significant toxicity to the host cell [1].

    价 格：￥电议型 号：T78926产 地：中国大陆

  • T78896SHP2-IN-22；化合物 SHP2-IN-22SHP2-IN-22

    SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-2 pancreatic cancer cells. This compound is utilized in the study of Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research [1].

    价 格：￥电议型 号：T78896产 地：中国大陆

  • T78194Skp2 inhibitor 2；化合物 Skp2 inhibitor 2Skp2 inhibitor 2

    Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1. This compound targets Skp2, a component of cullin-RING ligases that recruits and ubiquitinates substrates, playing roles in both proteolytic and non-proteolytic processes [1].

    价 格：￥电议型 号：T78194产 地：中国大陆

  • T78048rel-(2S,3R)-Voruciclib hydrochloride；化合物 rel-(2S,3R)-Voruciclib hydrochloriderel-(2S,3R)-Voruciclib

    Rel-(2S,3R)-Voruciclib hydrochloride is an enantiomer of Voruciclib hydrochloride, an orally active cyclin-dependent kinase (CDK) inhibitor.

    价 格：￥电议型 号：T78048产 地：中国大陆

  • T77577SLU-PP-332；化合物SLU-PP-332SLU-PP-332

    SLU-PP-332 is a pan-estrogen receptor-related receptor (ERR) agonist with high affinity for ERRα, ERRβ, and ERRγ with EC50 values of 98, 230, and 430 nM, respectively.SLUPP-332 enhances mitochondrial function and cellular respiration, increases type IIa oxidized skeletal muscle fibers, and enhances exercise tolerance in skeletal muscle cell lines. SLU-PP-332 has the potential to be used in the study of metabolic diseases and improvement of muscle function, and may be used to ameliorate metabolic

    价 格：￥电议型 号：T77577产 地：中国大陆

  • T77552SLU-PP-1072；化合物SLU-PP-1072SLU-PP-1072

    SLU-PP-1072 is an ERRα and ERRγ inverse dual agonist that disrupts PCa cell metabolism and induces apoptosis through cell cycle dysregulation.SLU-PP-1072 is used to study prostate cancer (PCa).

    价 格：￥电议型 号：T77552产 地：中国大陆

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