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  • T78841Nrf2-IN-3；化合物 Nrf2-IN-3Nrf2-IN-3

    Nrf2-IN-3 (Compound R16), a Nrf2 inhibitor, binds to KEAP1 mutants (G333C mKEAP1) thereby restoring the impaired KEAP1/NRF2 interactions. This restoration sensitizes KEAP1-mutant cancer cells to chemotherapeutic agents, such as Cisplatin and Gefitinib, by reestablishing the functionality of the mKEAP1/NRF2 complex [1].

    价 格：￥电议型 号：T78841产 地：中国大陆

  • T78721Smurf1-IN-1；化合物 Smurf1-IN-1Smurf1-IN-1

    Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in a rat model of pulmonary hypertension [1].

    价 格：￥电议型 号：T78721产 地：中国大陆

  • T78697Keap1-Nrf2-IN-15；化合物 Keap1-Nrf2-IN-15Keap1-Nrf2-IN-15

    Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay [1].

    价 格：￥电议型 号：T78697产 地：中国大陆

  • T78696Nrf2 activator-7；化合物 Nrf2 activator-7Nrf2 activator-7

    Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.

    价 格：￥电议型 号：T78696产 地：中国大陆

  • T78650Nrf2 activator-3；Nrf2 激活剂3Nrf2 activator-3

    Nrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant and anti-tumor activity, which can be used to study neurological and immune-related diseases.

    价 格：￥电议型 号：T78650产 地：中国大陆

  • T78544KRFK TFA；化合物 KRFK TFAKRFK TFA

    KRFK TFA, a TSP-1-derived peptide, activates TGF-β and enhances its associated signaling pathways independently of thrombospondin (TSP) receptors like CD47 and CD36. This compound has potential applications in research on chronic ocular surface inflammatory disorders [1].

    价 格：￥电议型 号：T78544产 地：中国大陆

  • T78236MuRF1-IN-2；化合物 MuRF1-IN-2MuRF1-IN-2

    MuRF1-IN-2 (Example 3) serves as a MuRF1 inhibitor, applicable for investigating conditions associated with muscle wasting, including both skeletal and cardiac muscle atrophy [1].

    价 格：￥电议型 号：T78236产 地：中国大陆

  • T78052Acifluorfen-methyl；化合物 Acifluorfen-methylAcifluorfen-methyl

    Acifluorfen-methyl, a photobleaching herbicide [1], functions as an inhibitor of the enzyme protoporphyrinogen oxidase (Protox), which is crucial for heme and chlorophyll biosynthesis.

    价 格：￥电议型 号：T78052产 地：中国大陆

  • T78039Acetyl-(D-Arg2)-GRF (1-29) amide (human)；化合物 Acetyl-(D-Arg2)-GRF (1-29) amide (human)Acetyl-(D-Arg2)

    Acetyl-(D-Arg2)-GRF (1-29) amide (human) serves as an antagonist to growth hormone-releasing factor (GRF) and inhibits growth hormone (GH) secretion, with applications in endocrine research [1].

    价 格：￥电议型 号：T78039产 地：中国大陆

  • T78035[K15,R16,L27]VIP(1-7)/GRF(8-27) acetate；化合物 [K15,R16,L27]VIP(1-7)/GRF(8-27) acetate[K15,R16,L27]VIP(

    [K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate) is an acetate salt form of the peptide [K15,R16,L27]VIP(1-7)/GRF(8-27). This compound acts as a selective agonist for the VIP 1 receptor, displaying IC50 values of 2 nM for human VIP 1, 1 nM for rat VIP 1, and 30,000 nM for rat VIP 2 receptors [1]. The peptide´s acronym, VIP, stands for Vasoactive Intestinal Polypeptide.

    价 格：￥电议型 号：T78035产 地：中国大陆

  • T77935Tri-GalNAc(OAc)3-Perfluorophenyl；化合物 Tri-GalNAc(OAc)3-PerfluorophenylTri-GalNAc(OAc)3-Perfluoropheny

    Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl-modified triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand utilized in the synthesis of GalNAc-lysosome-targeting chimeras (LYTACs). These chimeras facilitate targeted protein degradation through engagement with the asialoglycoprotein receptor [1].

    价 格：￥电议型 号：T77935产 地：中国大陆

  • T77727Feeblin；IRF5抑制剂5IRF5-IN-1；IRF5-IN-1

    Feeblin（IRF5-IN-1） is a protein degradation inducer that specifically blocks pro-inflammatory signaling pathways associated with autoimmune diseases and can be used to study immune system disorders in the class of systemic lupus erythematosus.

    价 格：￥电议型 号：T77727产 地：中国大陆

  • T7724Tepoxalin；替泊沙林RWJ-20485|||RWJ20485|||ORF20485|||ORF-20485|||RWJ 20485|||ORF 20485；RWJ-20485|||RWJ204

    Tepoxalin (RWJ 20485) is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, COX-2, and 5-LOX. Tepoxalin is a potent inhibitor of sheep seminal vesicle cyclooxygenase (COX) (IC50 = 4.6 microM), rat basophilic leukemia cell (RBL-1) lysate COX (IC50 = 2.85 microM) and COX from intact RBL-1 cells (IC50 = 4.2 microM).

    价 格：￥电议型 号：T7724产 地：中国大陆

  • T77087Mipeginterferon alfa-2b；化合物 Mipeginterferon alfa-2bMipeginterferon alfa-2b

    Mipeginterferon alfa-2b, an analog of interferon alpha-2b (IFNA2B), features an average substitution of 5 among its 11 amino groups (one N-terminal and 10 lysine N6), and exhibits a relative molecular mass of 40 kDa [1].

    价 格：￥电议型 号：T77087产 地：中国大陆

  • T77038Interferon alfa；化合物 Interferon alfaInterferon alfa

    Interferon alfa, a type I interferon, activates new genes, displaying strong antiviral and antiproliferative effects on target cells. It signals through receptor-mediated activation of Stat1 and Stat2, which heterodimerize into a STAT complex binding with the DNA-binding protein IRF-9 (p48) to form ISGF-3 (IFN-stimulated gene factor 3). This complex further activates driver genes to fulfill its antiviral role [1].

    价 格：￥电议型 号：T77038产 地：中国大陆

  • T76943Cepeginterferon alfa-2b；化合物 Cepeginterferon alfa-2bCepeginterferon alfa-2b

    Cepeginterferon alfa-2b, a pegylated interferon, features a polyethylene glycol (PEG) base with a molecular weight of 20 kDa. This compound is utilized in the research of numerous diseases, including hepatitis C virus (HCV), polycythemia vera (PV), and essential thrombocythemia (ET) [1] [2].

    价 格：￥电议型 号：T76943产 地：中国大陆

  • T76937Burfiralimab；化合物 BurfiralimabhzVSF-v13；hzVSF-v13

    Burfiralimab (hzVSF-v13) is a monoclonal immunoglobulin (IgG4) directed against waveform proteins thathas anti-HBV effects and can be used to study rheumatoid arthritis,

    价 格：￥电议型 号：T76937产 地：中国大陆

  • T76853Ropeginterferon alfa-2b；化合物 Ropeginterferon alfa-2bRopeginterferon alfa-2b

    Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].

    价 格：￥电议型 号：T76853产 地：中国大陆

  • T76602(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)；化合物 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41)

    (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a corticotropin-releasing factor (CRF) antagonist known to counteract the inhibitory effects of IL-1a on Luteinizing hormone (LH) production [1].

    价 格：￥电议型 号：T76602产 地：中国大陆

  • T76497KRFK；化合物 KRFKKRFK

    KRFK, a peptide originating from TSP-1, activates TGF-β and facilitates TGF-β-mediated signaling pathways, independently of thrombospondin (TSP) receptors like CD47 and CD36. This property makes KRFK a potential research tool for chronic ocular surface inflammatory disorders [1].

    价 格：￥电议型 号：T76497产 地：中国大陆

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