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  • T63542SHR902275;化合物 SHR902275SHR902275

    SHR902275 is a selective, potent, orally active RAF inhibitor capable of targeting RAS mutant cancers. SHR902275 acts on cRAF (IC50: 1.6 nM), bRAFwt (IC50: 10 nM), bRAFV600E (IC50: 5.7 nM). SHR902275 has cell growth inhibitory effects and acts on H358 cells (GI50: 1.5 nM), A375 cells (GI50: 0.17 nM), Calu6 cells (GI50: 0.4 nM) and SK-MEL2 cells (GI50: 0.32 nM).

    价 格:¥电议型 号:T63542产 地:中国大陆

  • T63541HPK1-IN-27;化合物 HPK1-IN-27HPK1-IN-27

    HPK1-IN-27 is a potent inhibitor of HPK1. Among them, MAP4K1, also known as hematopoietic progenitor kinase 1 (HPK1), is a member of the germinal center kinase family and is a serine/threonine kinase. HPK1-IN-27 has shown research potential for cancer diseases.

    价 格:¥电议型 号:T63541产 地:中国大陆

  • T63540Astrophloxine;化合物AstrophloxineAstrophloxine

    Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples from Alzheimer´s disease (AD) mice.

    价 格:¥电议型 号:T63540产 地:中国大陆

  • T6354(+)-Usnic acid;(+)-地衣酸D-Usnic Acid|||(+)-Usniacin;D-Usnic Acid|||松萝酸|||(+)-Usniacin|||(+)-地衣酸

    (+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.

    价 格:¥电议型 号:T6354产 地:中国大陆

  • T63539Glucocorticoid receptor-IN-2;化合物 Glucocorticoid receptor-IN-2Glucocorticoid receptor-IN-2

    Glucocorticoid receptor-IN-2 is a selective regulator of the glucocorticoid receptor (GR) and exhibits anti-inflammatory activity. IC50: 0.171 nM) and also has some transcriptional activating effect on MMTV (EC50: 0.94 nM).

    价 格:¥电议型 号:T63539产 地:中国大陆

  • T635388-Azido-ADP disodium;化合物 8-Azido-ADP disodium8-Azido-ADP disodium

    8-Azido-ADP (disodium) is a covalently bound inhibitor of mitochondrial adenine nucleotide translocation that exhibits inhibition of the ADP-induced 4 to 3 normal shift in mitochondrial respiration. In a light-dependent reaction, 8-Azido-ADP (disodium) irreversibly inhibits adenine nucleotide exchange.

    价 格:¥电议型 号:T63538产 地:中国大陆

  • T63537SARS-CoV-2 3CLpro-IN-1;化合物 SARS-CoV-2 3CLpro-IN-1SARS-CoV-2 3CLpro-IN-1

    SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1].

    价 格:¥电议型 号:T63537产 地:中国大陆

  • T63536Dual FAAH/sEH-IN-1;化合物Dual FAAH/sEH-IN-1Dual FAAH/sEH-IN-1

    Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity.

    价 格:¥电议型 号:T63536产 地:中国大陆

  • T63535Enpp-1-IN-13;化合物 Enpp-1-IN-13Enpp-1-IN-13

    Enpp-1-IN-13 is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) inhibitor that is able to act on ENPP1 (IC50: 1.29 μM) and ENPP3 (IC50: 20.2 μM), exhibiting anticancer effects.

    价 格:¥电议型 号:T63535产 地:中国大陆

  • T63534PPTN hydrochloride;化合物PPTN盐酸盐PPTN hydrochloride

    PPTN hydrochloride is a potent, high-affinity, competitive, highly selective P2Y14 receptor antagonist (KB: 434 pM), but no agonist or antagonist activity at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12 or P2Y13 receptors, exhibiting anti-inflammatory and anti-immune effects.

    价 格:¥电议型 号:T63534产 地:中国大陆

  • T63533ZIKV-IN-4;化合物 ZIKV-IN-4ZIKV-IN-4

    ZIKV-IN-4 is a low cytotoxic, acid-stable anti-ZIKV agent with an EC50 value of 3.49 μM. ZIKV-IN-4 exhibited potent inhibition of ZIKV NS5 MTase.

    价 格:¥电议型 号:T63533产 地:中国大陆

  • T63532EGFR/HER2/TS-IN-2;化合物 EGFR/HER2/TS-IN-2EGFR/HER2/TS-IN-2

    EGFR/HER2/TS-IN-2 is a potent inhibitor of EGFR (IC50: 0.173 μM), HER2 (IC50: 0.125 μM) and TS (IC50: 1.12 μM). EGFR/HER2/TS-IN-2 exhibited cytotoxic effects on MDA-MB-231 cancer cells (IC50: 1.69 μM ).

    价 格:¥电议型 号:T63532产 地:中国大陆

  • T63531HDAC6/HSP90-IN-1;化合物 HDAC6/HSP90-IN-1HDAC6/HSP90-IN-1

    HDAC6/HSP90-IN-1 is a potent and selective dual inhibitor of HDAC6 (IC50: 4.3 nM) and HSP90 (IC50: 46.8 nM).HDAC6/HSP90-IN-1 downregulates PD-L1 expression in INF-γ-treated H1975 lung cancer cells.HDAC6/HSP90-IN-1 exhibits tumor growth inhibition in H1975 xenograft mice.HDAC6/HSP90-IN-1 is a potent and selective dual inhibitor of HDAC6 (IC50: 4.3 nM) and HSP90 (IC50: 46.8 nM). 1 exhibited tumor growth inhibition in H1975 xenograft mice.

    价 格:¥电议型 号:T63531产 地:中国大陆

  • T63530Apoptotic agent-3;化合物 Apoptotic agent-3Apoptotic agent-3

    Apoptotic agent-3 utilizes a potential mitochondrial-mediated Bcl-2/Bax pathway and activates the caspase-3 pathway to promote apoptosis, exhibiting anti-proliferative effects that can be used to study cancer.

    价 格:¥电议型 号:T63530产 地:中国大陆

  • T6353(-)-p-Bromotetramisole Oxalate;(-)-对溴四咪唑草酸盐L-p-Bromotetramisole oxalate|||6-Bromolevamisole oxalate|

    (-)-p-Bromotetramisole Oxalate (6-Bromolevamisole oxalate) is a potent and non-specific inhibitor of alkaline phosphatase.

    价 格:¥电议型 号:T6353产 地:中国大陆

  • T63529HDAC/HSP90-IN-3;化合物 HDAC/HSP90-IN-3HDAC/HSP90-IN-3

    HDAC/HSP90-IN-3 is a selective and potent dual inhibitor of fungal Hsp90 (IC50: 0.83 μM) and HDAC (IC50: 0.91 μM), exhibiting antifungal effects against azole-resistant Candida albicans. HDAC/HSP90-IN-3 exhibits inhibitory effects on important virulence factors and is able to downregulate the resistance genes ERG11 and CDR1.

    价 格:¥电议型 号:T63529产 地:中国大陆

  • T63528HSP90-IN-11;化合物 HSP90-IN-11HSP90-IN-11

    HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90α inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cells, HSP90-IN-11 exhibited significant anti-proliferative activity in the double-digit nM range.HSP90-IN-11 was able to rapidly degrade client proteins EGFR and Akt in NSCLC cells.

    价 格:¥电议型 号:T63528产 地:中国大陆

  • T63526Topoisomerase I/II inhibitor 4;化合物 Topoisomerase I/II inhibitor 4Topoisomerase I/II inhibitor 4

    Topoisomerase I/II inhibitor 4 is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) with inhibitory effects on cell proliferation, invasion and migration, and induction of apoptosis, and can be used to study hepatocellular carcinoma.

    价 格:¥电议型 号:T63526产 地:中国大陆

  • T63525Antitubercular agent-23;化合物 Antitubercular agent-23Antitubercular agent-23

    Antitubercular agent-23 is an effective anti-Candida and anti-tuberculosis agent against Candida albicans MTCC 3017 (MIC: 1.1 μg/ml) and M. tuberculosis (H37Rv) (MIC: 1 μg/ml).

    价 格:¥电议型 号:T63525产 地:中国大陆

  • T63524ATX inhibitor 10;化合物 ATX inhibitor 10ATX inhibitor 10

    ATX inhibitor 10 is a nitrogen-containing heterocyclic compound that is a potent inhibitor of ATX. Among other things, ATX plays a role in causing pathologies including fibrosis, neurodegeneration, arthritis, neuropathic pain, and cancer. ATX inhibitor 10 has shown research potential for ATX-related diseases.

    价 格:¥电议型 号:T63524产 地:中国大陆

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