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  • T63560ZLWH-23；化合物 ZLWH-23ZLWH-23

    ZLWH-23 is a selective inhibitor of acetylcholinesterase (AChE) (IC50: 0.27 μM) and inhibits GSK-3β with an IC50 value of 6.78 μM. ZLWH-23 selectively acts on BChE (IC50=20.82 μM) and on multiple kinases as well as GSK-3β. ZLWH-23 has potential for ZLWH-23 has potential for Alzheimer´s disease research.

    价 格：￥电议型 号：T63560产 地：中国大陆

  • T6356(R)-Nepicastat HCl；盐酸内匹司他RS-25560-198 HCl；RS-25560-198 HCl|||盐酸内匹司他

    (R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

    价 格：￥电议型 号：T6356产 地：中国大陆

  • T63559IRAK4-IN-22；化合物 IRAK4-IN-22IRAK4-IN-22

    IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN-21 can be used to study autoimmune diseases, such as plaque psoriasis and psoriatic arthritis.

    价 格：￥电议型 号：T63559产 地：中国大陆

  • T63558IRAK4-IN-21；化合物 IRAK4-IN-21IRAK4-IN-21

    IRAK4-IN-21 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 5 nM) and TAK1 (IC50: 56 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.17 μM. can be used to study autoimmune diseases, such as plaque psoriasis and psoriatic arthritis.

    价 格：￥电议型 号：T63558产 地：中国大陆

  • T63557hCA I-IN-1；化合物 hCA I-IN-1hCA I-IN-1

    hCA I-IN-1 is a human carbonic anhydrase I (hCA I) inhibitor that acts on hCA I (Ki: 38.3 nM), hCA II (Ki: 716.4 nM), hCAIX (Ki: 940.1 nM) and hCAXII (Ki: 192.8 nM).

    价 格：￥电议型 号：T63557产 地：中国大陆

  • T63556EGFR-IN-59；化合物 EGFR-IN-59EGFR-IN-59

    EGFR-IN-59 is an EGFR inhibitor with an IC50 value of 190 nM and an all-time apoptosis inducer. EGFR-IN-59 exhibited cytotoxicity against a non-small lung cancer cell line (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 μM, respectively. EGFR-IN-59 EGFR-IN-59 can be used to study a variety of cancers including non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer.

    价 格：￥电议型 号：T63556产 地：中国大陆

  • T63555ATR-IN-6；化合物 ATR-IN-6ATR-IN-6

    ATR-IN-6 is a potent inhibitor of ATR. ATR is a protein kinase that is involved in genome stability and DNA damage repair and is a member of the PIKK family. aTR-IN-6 has shown potential for ATR kinase-mediated diseases such as proliferative diseases and cancer.

    价 格：￥电议型 号：T63555产 地：中国大陆

  • T63554TGR5 Receptor Agonist 3；化合物 TGR5 Receptor Agonist 3TGR5 Receptor Agonist 3

    TGR5 Receptor Agonist 3 is a G protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonist soft drug compound that decreases gallbladder filling, exhibits good gallbladder safety, and is able to act on hTGR5 (EC50: 16.4 nM) and mTGR5 (EC50: 209 nM).

    价 格：￥电议型 号：T63554产 地：中国大陆

  • T63553HPK1-IN-28；化合物 HPK1-IN-28HPK1-IN-28

    HPK1-IN-28 is a potent inhibitor of HPK1, a negative regulator of dendritic cell (DC), T-cell and B-cell activation responses. HPK1-IN-28 is effective in enhancing anti-tumor immunity in humans and has shown research potential in immune-related diseases, especially tumors.

    价 格：￥电议型 号：T63553产 地：中国大陆

  • T63552FtsZ-IN-1；化合物 FtsZ-IN-1FtsZ-IN-1

    FtsZ-IN-1 is a potent FtsZ inhibitor with a quinoline ring and has a strong inhibitory effect on Gram-positive bacteria (MIC: 0.5-8 μg/mL).FtsZ-IN-1 enhances FtsZ polymerization and significantly promotes cell elongation of Bacillus subtilis.FtsZ-IN-1 has low hemolytic toxicity and low FtsZ-IN-1 exhibited anti-drug-resistant bacterial effects due to its low hemolytic toxicity and low tendency to induce drug resistance.

    价 格：￥电议型 号：T63552产 地：中国大陆

  • T63551Glucocorticoid receptor-IN-1；化合物 Glucocorticoid receptor-IN-1Glucocorticoid receptor-IN-1

    Glucocorticoid receptor-IN-1 is a selective regulator of the glucocorticoid receptor (GR) and exhibits anti-inflammatory activity. glucocorticoid receptor-IN-1 has good transcriptional repression, acting on hMMP1 ( IC50: 2.11 nM) and also has a transcriptional activating effect on MMTV (EC50: 5.59 nM).

    价 格：￥电议型 号：T63551产 地：中国大陆

  • T63550(1S,3R,5R)-PIM447 dihydrochloride；化合物 (1S,3R,5R)-PIM447 dihydrochloride(1S,3R,5R)-PIM447 dihydrochlo

    (1S,3R,5R)-PIM447 (dihydrochloride) is an inhibitor of PIM, capable of Pim1 (IC50: 0.095 μM), Pim2 (IC50: 0.522 μM) and Pim3 (IC50: 0.369 μM).

    价 格：￥电议型 号：T63550产 地：中国大陆

  • T6355(R)-baclofen；(R)-巴氯芬STX209|||Arbaclofen；STX209|||Arbaclofen|||(R)-巴氯芬

    (R)-baclofen (STX209), a derivative of gamma-aminobutyric acid, is commonly utilized for the treatment of spasticity.

    价 格：￥电议型 号：T6355产 地：中国大陆

  • T63549MRGPRX1 agonist 4；化合物 MRGPRX1 agonist 4MRGPRX1 agonist 4

    MRGPRX1 agonist 4 is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive conformation modulator (EC50: 0.1 μM). MRGPRX1 agonist 4 ameliorated the behavioral thermal allergic response in mice, a model of MRGPRX1 neuropathic pain.

    价 格：￥电议型 号：T63549产 地：中国大陆

  • T63548APJ receptor agonist 3；化合物 APJ receptor agonist 3APJ receptor agonist 3

    APJ receptor agonist 3 is a highly effective and orally administerable agonist of the APJ receptor, demonstrating a potent EC50 value of 0.027 nM.

    价 格：￥电议型 号：T63548产 地：中国大陆

  • T63547MEK1/2-IN-2；化合物 MEK1/2-IN-2MEK1/2-IN-2

    MEK1/2-IN-2 is a potent, ATP-competitive MEK1/2 inhibitor that exhibits equal inhibitory effects on wild-type MEK1/2 and a group of MEK1/2 mutant cells.

    价 格：￥电议型 号：T63547产 地：中国大陆

  • T63546DG013A；化合物 DG013ADG013A

    DG013A is a mimetic inhibitor of hypophosphonic acid tripeptides, capable of acting on ERAP1 (IC50: 33 nM) and ERAP2 (IC50: 11 nM).DG013A can be used to study autoimmune diseases and cancer.

    价 格：￥电议型 号：T63546产 地：中国大陆

  • T63545FAK-IN-3；化合物 FAK-IN-3FAK-IN-3

    FAK-IN-3 is a potent inhibitor of adherens spot kinase (FAK). FAK-IN-3 reduces migration and invasion of PA-1 cells and inhibits the expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis with no significant adverse effects. FAK-IN-3 has shown investigational potential in ovarian cancer.

    价 格：￥电议型 号：T63545产 地：中国大陆

  • T63544RIPK3-IN-1；RIPK3 抑制剂 1RIPK3-IN-1

    RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumorigenic activity and can be used to study apoptosis.

    价 格：￥电议型 号：T63544产 地：中国大陆

  • T63543HDAC/Top-IN-1；化合物 HDAC/Top-IN-1HDAC/Top-IN-1

    HDAC/Top-IN-1 is a broad-spectrum, orally active dual HDAC/Top inhibitor that acts on HDAC1 (IC50: 0.036 μM), HDAC2 (IC50: 0.14 μM), HDAC3 (IC50: 0.059 μM), HDAC6 (IC50: 0.089 μM) and HDAC8 ( IC50: 9.8 μM). HDAC/Top-IN-1 was able to block HEL cells in S-phase and effectively induce apoptosis.

    价 格：￥电议型 号：T63543产 地：中国大陆

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