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T63523Duocarmycin analog-2；化合物 Duocarmycin analog-2Duocarmycin analog-2
Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers.
价 格：￥电议型 号：T63523产 地：中国大陆
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T63522Anticancer agent 64；化合物 Anticancer agent 64Anticancer agent 64
Anticancer agent 64 (compound 5m) demonstrates effective cytotoxic activity against CCRF-CEM cells, exhibiting an IC50 value of 2.4 μM. It effectively induces apoptosis in cancer cells by activating caspase 3 and 7 and causing PARP cleavage. Additionally, it significantly disrupts mitochondrial membrane potential, contributing to its anticancer efficacy [1].
价 格：￥电议型 号：T63522产 地：中国大陆
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T63521Bcl-2-IN-7；化合物 Bcl-2-IN-7Bcl-2-IN-7
Bcl-2-IN-7 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2), which can downregulate the expression of Bcl-2, increase the expression of p53, Bax, caspase-7 mRNA, and induce cell cycle arrest and apoptosis in MCF-7 cells of breast cancer. Bcl2-IN-7 showed good antitumor activity against MCF-7 cells (IC50: 20.17 μM), LoVo cells (IC50: 22.64 μM), HepG2 cells (IC50: 45.57 μM) and A549 cells (IC50: 51.50 μM).
价 格：￥电议型 号：T63521产 地：中国大陆
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T63520ChemR23-IN-2；化合物 ChemR23-IN-2ChemR23-IN-2
ChemR23-IN-2 is a potent, orally active inhibitor of ChemR23 (IC50: 3.2 nM).
价 格：￥电议型 号：T63520产 地：中国大陆
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T6352(-)-Dizocilpine maleate；(-)-MK 801马来酸C13737|||(-)-MK 801 (Maleate)|||(-)-MK 801 Maleate；C13737|||(-)
(-)-Dizocilpine maleate ((-)-MK 801 (Maleate)) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
价 格：￥电议型 号：T6352产 地：中国大陆
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T63519Cap-dependent endonuclease-IN-13；化合物 Cap-dependent endonuclease-IN-13Cap-dependent endonuclease-IN-1
Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN) and shows research potential against influenza virus infection (influenza A only).
价 格：￥电议型 号：T63519产 地：中国大陆
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T63518USP1-IN-2；USP1 抑制剂2USP1-IN-2
USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.
价 格：￥电议型 号：T63518产 地：中国大陆
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T63517BuChE-IN-4；化合物 BuChE-IN-4BuChE-IN-4
BuChE-IN-4 is a potent inhibitor of BuChE (IC50: 7.7 nM) and exhibits mild antioxidant capacity, non-toxicity, lipophilicity and neuroprotective effects.
价 格：￥电议型 号：T63517产 地：中国大陆
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T63516NRX-252114；化合物NRX-252114NRX252114|||NRX 252114；NRX252114|||NRX 252114
NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.
价 格：￥电议型 号：T63516产 地：中国大陆
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T63515THR-β agonist 4；化合物 THR-β agonist 4THR-β agonist 4
THR-β agonist 4 is a potent agonist of THR-β. THR-β agonist 4 has shown research potential for metabolic diseases such as hyperlipidemia, obesity, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases.
价 格：￥电议型 号：T63515产 地：中国大陆
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T63514PPARγ agonist 1；化合物 PPARγ agonist 1PPARγ agonist 1
PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects. pparγ agonist 1 has shown research potential in cardiovascular diseases associated with metabolic disorders.
价 格：￥电议型 号：T63514产 地：中国大陆
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T63513Antitumor agent-71；化合物 Antitumor agent-71Antitumor agent-71
Antitumor Agent-71 is an antitumor compound that exhibits an inhibitory effect on tubulin aggregation. antitumor Agent-71 possesses an anti-proliferative effect with IC50 values ranging from 3.98-15.70 μM against tumor cell lines.
价 格：￥电议型 号：T63513产 地：中国大陆
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T63512LpxC-IN-10；化合物 LpxC-IN-10LpxC-IN-10
LpxC-IN-10 is a selective LpxC inhibitor with an MIC of 0.5 μg/mL against E. coli and K. pneumoniae and is capable of being used to study bacterial infections.
价 格：￥电议型 号：T63512产 地：中国大陆
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T63511IRE1α kinase-IN-4；化合物 IRE1α kinase-IN-4IRE1α kinase-IN-4
IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].
价 格：￥电议型 号：T63511产 地：中国大陆
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T63510ATX inhibitor 21；化合物 ATX inhibitor 21ATX inhibitor 21
ATX inhibitor 21 is a potent inhibitor of ATX (IC50: 3490 nM).
价 格：￥电议型 号：T63510产 地：中国大陆
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T6351MGCD-265 analog；化合物MGCD-265 analogMGCD-265|||Glesatinib；MGCD-265|||Glesatinib
MGCD-265 analog (Glesatinib) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively.
价 格：￥电议型 号：T6351产 地：中国大陆
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T63509Top/HDAC-IN-1；化合物 Top/HDAC-IN-1Top/HDAC-IN-1
Top/HDAC-IN-1 is a dual topoisomerase (Top)/HDAC inhibitor that acts on HDAC1 (IC50: 18 nM), HDAC2 (IC50: 230 nM), HDAC3 (IC50: 790 nM), HDAC6 (IC50: 87 nM) and HDAC8 (IC50: 5250 nM). Top/HDAC-IN-1 exhibited potent antitumor effects on HCT116 cells (IC50: 180 nM), blocked the cell cycle of HCT116 cells in G2 phase, and effectively induced apoptosis.
价 格：￥电议型 号：T63509产 地：中国大陆
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T63508OM-153；化合物 OM-153OM-153
OM-153 is a potent inhibitor of tankyrase, acting on tankyrase 1 (IC50: 13 nM) and tankyrase 2 (IC50: 2 nM), and inhibiting WNT/β-linked protein signaling and proliferation in COLO 320DM.
价 格：￥电议型 号：T63508产 地：中国大陆
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T63507Feniralstat；化合物 FeniralstatFeniralstat
Feniralstat is a pyrazole derivative, a potent inhibitor of kallikrein, which inhibits human plasma kinase (pKal) (IC50: 6.7 nM).Feniralstat does not inhibit human KLK1, human FXIa and human factor Xlla (IC50 >40 μM).
价 格：￥电议型 号：T63507产 地：中国大陆
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T63506Chroman 1 dihydrochloride；化合物 Chroman 1 dihydrochlorideChroman 1 dihydrochloride
Chroman 1 dihydrochloride is a selective and potent inhibitor of ROCK, acting more strongly on ROCK2 (IC50: 1 pM) than ROCK1 (IC50: 52 pM) and also inhibiting MRCK activity (IC50: 150 nM).
价 格：￥电议型 号：T63506产 地：中国大陆
