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T13550AP5;化合物 T13550AP5
AP5 is a potent and selective agonist for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49 nM against the GPR40 receptor.
价 格:¥电议型 号:T13550产 地:中国大陆
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T13336LVTP50469 fumarate;化合物 T13336LVTP50469 fumarate
VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.
价 格:¥电议型 号:T13336L产 地:中国大陆
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T13336VTP50469;化合物VTP50469VTP50469
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
价 格:¥电议型 号:T13336产 地:中国大陆
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T13253Umibecestat;化合物UmibecestatCNP520;CNP520
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer´s disease.
价 格:¥电议型 号:T13253产 地:中国大陆
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T13140Umbralisib R-enantiomer;厄布利塞R对映体TGR-1202 R-enantiomer|||RP5264 R-enantiomer;TGR-1202 R-enantiomer|||
Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against δPI3 kinase is at least 20 times lower than that of the inhibitors against other PI3K isoforms (A, β, and γ).
价 格:¥电议型 号:T13140产 地:中国大陆
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T12791(S)-3-Hydroxy Midostaurin;化合物 T12791(S)-CGP52421;(S)-CGP52421
(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)).
价 格:¥电议型 号:T12791产 地:中国大陆
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T12610L3-Hydroxy Midostaurin;化合物 T12610LCGP52421;CGP52421
3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM in culture medium and 9.8 μM in plasma. Though less selective, it exhibits greater cytotoxicity compared to PKC412[1].
价 格:¥电议型 号:T12610L产 地:中国大陆
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T12610(R)-3-Hydroxy Midostaurin;化合物 T12610(R)-CGP52421;(R)-CGP52421
(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).
价 格:¥电议型 号:T12610产 地:中国大陆
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T12351p53 and MDM2 proteins-interaction-inhibitor (racemic);化合物 T12351p53-and-mdm2-proteins-interaction-in
p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.
价 格:¥电议型 号:T12351产 地:中国大陆
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T12350p53 and MDM2 proteins-interaction-inhibitor dihydrochloride;化合物 T12350p53 and MDM2 proteins-interact
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.
价 格:¥电议型 号:T12350产 地:中国大陆
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T10930D-AP5;(R)-(-)-2-氨基-5-膦酰戊酸D-APV|||D-2-Amino-5-phosphonovaleric acid;(R)-(-)-2-氨基-5-膦酰戊酸|||D-APV|||D-2
D-AP5 (D-APV) is a NMDA receptor antagonist.
价 格:¥电议型 号:T10930产 地:中国大陆
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T10875CP5V;化合物 T10875CP5V
CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation.
价 格:¥电议型 号:T10875产 地:中国大陆
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T10782CGP52411;化合物CGP52411DAPH;DAPH
CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42 fibril aggregates. CGP52411 can be used in studies about Alzheimer´s diseases.
价 格:¥电议型 号:T10782产 地:中国大陆
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T10344AP521;化合物 T10344AP521
AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM).
价 格:¥电议型 号:T10344产 地:中国大陆
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T0186Docetaxel trihydrate;多西他赛三水合物RP-56976 (Trihydrate)|||RP56976 (NSC 628503) Trihydrate;RP-56976 (Trihy
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor including breast and lung cancer. Therapy with docetaxel has been associated with a low rate of serum enzyme elevations and rarely to instances of acute hepatic necrosis generally due to severe hypersensitivity reactions or sepsis.
价 格:¥电议型 号:T0186产 地:中国大陆